Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
暂无分享,去创建一个
Jussi Paananen | Mark Walker | Torben Hansen | Leif Groop | Andrew R. Wood | Themistocles L. Assimes | Oluf Pedersen | Timothy M. Frayling | John J. Nolan | Thomas Quertermous | T. Assimes | T. Hansen | O. Pedersen | L. Groop | M. Laakso | T. Frayling | M. Weedon | M. Walker | J. Knowles | V. Lyssenko | J. Dekker | U. Smith | A. Wood | T. Quertermous | E. Ferrannini | J. Nolan | H. Häring | W. Gall | Klaus-Peter Adam | Weijia Xie | F. Abbasi | Ele Ferrannini | Joshua W. Knowles | Markku Laakso | Valeriya Lyssenko | Jacqueline M. Dekker | Klaus-Peter Adam | Weijia Xie | Michael N. Weedon | J. Paananen | Fahim Abbasi | Sami Alkayyali | Hans Häring | Ulf Smith | Walter E. Gall | S. Alkayyali | Weijia Xie | Sami Alkayyali | Weijia Xie | T. Hansen
[1] SoJung Lee,et al. Metabolomic profiling of amino acids and β-cell function relative to insulin sensitivity in youth. , 2012, The Journal of clinical endocrinology and metabolism.
[2] Ayellet V. Segrè,et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis , 2010, Nature Genetics.
[3] M. Walker,et al. The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and Objectives , 2004, Diabetologia.
[4] Yun Li,et al. METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..
[5] J. Hausman. Specification tests in econometrics , 1978 .
[6] H. Blom,et al. Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans. , 2000, Molecular Genetics and Metabolism.
[7] J. Gregory,et al. Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine. , 2007, The Journal of nutrition.
[8] A. Balasubramanyam,et al. Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine , 2010, Diabetes Care.
[9] Christian Gieger,et al. A genome-wide perspective of genetic variation in human metabolism , 2010, Nature Genetics.
[10] T. Hansen,et al. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study , 2008, Diabetologia.
[11] Luigi Ferrucci,et al. Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study , 2009, PLoS genetics.
[12] R. DeFronzo,et al. Impairment of Insulin-mediated Glucose Metabolism by Hyperosmolality in Man , 1983, Diabetes.
[13] Corey D. DeHaven,et al. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. , 2009, Analytical chemistry.
[14] G. Paolisso,et al. Glutathione Infusion Potentiates Glucose-Induced Insulin Secretion in Aged Patients With Impaired Glucose Tolerance , 1992, Diabetes Care.
[15] Juan P Casas,et al. Estimation of bias in nongenetic observational studies using "mendelian triangulation". , 2006, Annals of epidemiology.
[16] J. House,et al. Plasma homocysteine and glycine are sensitive indices of folate status in a rodent model of folate depletion and repletion. , 2003, Journal of agricultural and food chemistry.
[17] George Davey Smith,et al. Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology , 2008, Statistics in medicine.
[18] E. Cerasi,et al. Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. , 1972, The Journal of clinical investigation.
[19] Yun Li,et al. Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults. , 2010, Human molecular genetics.
[20] L. Brennan,et al. Amino acid metabolism, insulin secretion and diabetes. , 2007, Biochemical Society transactions.
[21] Abraham Nyska,et al. Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity , 2009, Toxicologic pathology.
[22] G. Abecasis,et al. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes , 2010, Genetic epidemiology.
[23] D. Lawlor,et al. Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al. , 2007, Annals of epidemiology.
[24] SiddharthPrakash. Human Metabolic Individuality in Biomedical and Pharmaceutical Research , 2011 .
[25] Fabian J Theis,et al. Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers , 2011, PLoS genetics.
[26] Inês Barroso,et al. Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies , 2011, PLoS medicine.
[27] Hans-Werner Mewes,et al. Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication. , 2008, Endocrinology.
[28] G. Abecasis,et al. Genotype imputation. , 2009, Annual review of genomics and human genetics.
[29] G. Shulman,et al. Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. , 1997, Diabetes.
[30] C. Gieger,et al. Human metabolic individuality in biomedical and pharmaceutical research , 2011, Nature.
[31] Mark I. McCarthy,et al. Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance , 2011, Diabetes.
[32] S. Craig,et al. Betaine in human nutrition. , 2004, The American journal of clinical nutrition.
[33] K. Kalari,et al. Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation. , 2011, Molecular genetics and metabolism.
[34] J. Limbeek,et al. Long-term reduction of plasma homocysteine levels by super-flux dialyzers in hemodialysis patients. , 2001, Kidney international.
[35] M. Jarvelin,et al. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes , 2009, Human molecular genetics.
[36] Luke Hunter,et al. Interpreting Metabolomic Profiles using Unbiased Pathway Models , 2010, PLoS Comput. Biol..
[37] Ru Wei,et al. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity , 2008, Molecular systems biology.
[38] W. Kraus,et al. Exercise-Induced Changes in Metabolic Intermediates, Hormones, and Inflammatory Markers Associated With Improvements in Insulin Sensitivity , 2010, Diabetes Care.
[39] Svati H Shah,et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. , 2009, Cell metabolism.
[40] L. Groop,et al. Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects , 1996, Diabetes.
[41] William E. Kraus,et al. Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women , 2009, Diabetes Care.
[42] Michael Milburn,et al. A Novel Fasting Blood Test for Insulin Resistance and Prediabetes , 2013, Journal of diabetes science and technology.
[43] T. Hansen,et al. Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study , 2008, Diabetologia.
[44] Oliver Fiehn,et al. Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women , 2010, PloS one.
[45] R. DeFronzo,et al. Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.
[46] Y. Le Marchand-Brustel,et al. Hyperosmotic Stress Inhibits Insulin Receptor Substrate-1 Function by Distinct Mechanisms in 3T3-L1 Adipocytes* , 2003, Journal of Biological Chemistry.
[47] Christian Gieger,et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.
[48] M. Milburn,et al. Analysis of the adult human plasma metabolome. , 2008, Pharmacogenomics.
[49] A. Barabasi,et al. Hierarchical Organization of Modularity in Metabolic Networks , 2002, Science.
[50] M. E. Clark,et al. Living with water stress: evolution of osmolyte systems. , 1982, Science.
[51] A. Peters,et al. Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach , 2013, Diabetes.
[52] Christian Gieger,et al. Novel biomarkers for pre-diabetes identified by metabolomics , 2012, Molecular systems biology.
[53] Andrea Natali,et al. α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population , 2010, PloS one.
[54] G. Reaven,et al. Assessment of Insulin Resistance with the Insulin Suppression Test and the Euglycemic Clamp , 1981, Diabetes.
[55] V. Mootha,et al. Metabolite profiles and the risk of developing diabetes , 2011, Nature Medicine.
[56] M. Summar. Molecular genetic research into carbamoyl-phosphate synthase I: Molecular defects and linkage markers , 1998, Journal of Inherited Metabolic Disease.