COLABOMYCINS, NEW ANTIBIOTICS OF THE MANUMYCIN GROUP FROM STREPTOMYCES GRISEOFLA ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

The yellow colabomycins Ato C, three newantibiotics of the manumycingroup produced by Streptomyces griseoflavus (strain Tu 2880), were detected by chemical screening. They were isolated from mycelium extracts by columnchromatography on various adsorbents, followed by preparative reversed phase HPLC. The main compound, colabomycin A (1), was characterized and shown to be chiefly biologically active against Gram-positive bacteria and stem cells of murine LI210 leukemia. The colabomycin-complexwas detected in the course of our chemical screening program. On silica gel TLCplates Table 1) the bright yellow compounds showed reactions with various reducing Under examination with

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