The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes.

[1]  A. Soares,et al.  Antitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derived from its C-terminal region. , 2009, Biologicals : journal of the International Association of Biological Standardization.

[2]  M. Fontes,et al.  Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site. , 2009, Journal of structural biology.

[3]  J. Gutiérrez,et al.  The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles. , 2009, Protein and peptide letters.

[4]  T. Pozzan,et al.  Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors , 2009, Cellular and Molecular Life Sciences.

[5]  R A Knight,et al.  Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes , 2009, Cell Death and Differentiation.

[6]  J. Gutiérrez,et al.  Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action , 2008, Cellular and Molecular Life Sciences.

[7]  J. Gutiérrez,et al.  Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.

[8]  Edward A Dennis,et al.  The phospholipase A2 superfamily and its group numbering system. , 2006, Biochimica et biophysica acta.

[9]  J. Gutiérrez,et al.  Confronting the Neglected Problem of Snake Bite Envenoming: The Need for a Global Partnership , 2006, PLoS medicine.

[10]  B. Lomonte,et al.  Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms , 2005, Cell biochemistry and function.

[11]  R. Arni,et al.  A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change* , 2005, Journal of Biological Chemistry.

[12]  Jonathan A. Campbell,et al.  The Venomous Reptiles of the Western Hemisphere , 2005 .

[13]  J. Gutiérrez,et al.  Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity. , 2003, Toxicon : official journal of the International Society on Toxinology.

[14]  R. Ward,et al.  Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis. , 2003, Toxicon : official journal of the International Society on Toxinology.

[15]  B. Lomonte,et al.  An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action. , 2003, Toxicon : official journal of the International Society on Toxinology.

[16]  C. Santamaria,et al.  Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms. , 2003, Toxicon : official journal of the International Society on Toxinology.

[17]  B. Lomonte,et al.  Identification of the myotoxic site of the Lys49 phospholipase A(2) from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities. , 2001, Toxicon : official journal of the International Society on Toxinology.

[18]  C. Ownby,et al.  cDNA cloning and sequence analysis of a lysine-49 phospholipase A2 myotoxin from Agkistrodon contortrix laticinctus snake venom. , 1996, Archives of biochemistry and biophysics.

[19]  B. Lomonte,et al.  Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling. , 1994, The Journal of biological chemistry.

[20]  J. Drenth,et al.  A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom. , 1985, The Journal of biological chemistry.