Epidural pethidine: pharmacology and clinical experience.

Pethidine is an effective epidural opioid for the treatment of acute pain. Its use has been well described in Australian and New Zealand practice, particularly in the field of obstetric anaesthesia. Reported methods of delivery have included bolus injection, continuous infusion and patient-controlled epidural analgesia. Areas of application have included treatment of postoperative pain, labour pain and intraoperative pain. Because of its intermediate lipid solubility, pethidine may have advantages over many other epidural opioids. However, potential for accumulation of norpethidine limits its use to relatively short durations of treatment.

[1]  K. Khaw,et al.  Addition of adrenaline to pethidine for epidural analgesia after Caesarean section , 1997, Anaesthesia.

[2]  W. N. Ngan Kee,et al.  Epidural Meperidine After Cesarean Section: The Effect of Diluent Volume , 1997, Anesthesia and analgesia.

[3]  W. N. Ngan Kee,et al.  A Survey of Factors Influencing Patients ‘Choice of Anaesthesia for Caesarean Section , 1997, Australian and New Zealand journal of obstetrics and gynaecology.

[4]  K. Khaw,et al.  Patient-controlled epidural analgesia after Caesarean section using meperidine , 1997, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[5]  W. N. Kee.  Postoperative epidural opioid analgesia: what are the choices? , 1997 .

[6]  T. Gin,et al.  Comparison of Patient-Controlled Epidural Analgesia with Patient-Controlled Intravenous Analgesia Using Pethidine or Fentanyl , 1997, Anaesthesia and intensive care.

[7]  D. E. Roberts,et al.  A comparison of opioid solutions for patient‐controlled epidural analgesia , 1996, Anaesthesia.

[8]  W. N. Ngan Kee,et al.  Epidural Meperidine after Cesarean Section: A Dose‐Response Study , 1996, Anesthesiology.

[9]  R. Etches,et al.  Patient-Controlled Epidural Analgesia After Thoracotomy: A Comparison of Meperidine With and Without Bupivacaine , 1996, Anesthesia and analgesia.

[10]  D. Williams,et al.  A comparison of epidural infusions of fentanyl or pethidine with bupivacaine in the management of postoperative pain , 1996, Anaesthesia.

[11]  T. Gin,et al.  Evaluation of a Disposable Device for Patient-Controlled Epidural Analgesia after Caesarean Section , 1996, Anaesthesia and intensive care.

[12]  S. Evans,et al.  Patient-Controlled Epidural Analgesia following Caesarean Delivery: A Comparison of Pethidine and Fentanyl , 1996, Anaesthesia and intensive care.

[13]  M. Chaney.  Side effects of intrathecal and epidural opioids , 1995, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[14]  P. Slinger,et al.  Postthoracotomy pulmonary function: a comparison of epidural versus intravenous meperidine infusions , 1995 .

[15]  O. Rosaeg,et al.  Epidural opioid analgesia after Caesarean section: a comparison of patient-controlled analgesia with meperidine and single bolus injection of morphine , 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[16]  R. Miguel,et al.  A Prospective, Randomized, Double‐blind Comparison of Epidural and Intravenous Sufentanil Infusions , 1994, Anesthesiology.

[17]  M. Paech,et al.  Meperidine for Patient‐controlled Analgesia after Cesarean Section Intravenous Versus Epidural Administration , 1994, Anesthesiology.

[18]  M. Anderson,et al.  Paraplegia after continuous subdural meperidine infusion. , 1994, Anesthesiology.

[19]  P. Macintyre,et al.  Norpethidine toxicity and patient controlled analgesia. , 1993, British journal of anaesthesia.

[20]  M. Lawlor,et al.  Epidural meperidine provides surgical anesthesia for critically ill patients undergoing major surgery. , 1993, Anesthesia and analgesia.

[21]  S. Chrubasik,et al.  The ideal epidural opioid--fact or fantasy? , 1993, European journal of anaesthesiology.

[22]  R. Geller.  Meperidine in patient-controlled analgesia: a near-fatal mishap. , 1993, Anesthesia and analgesia.

[23]  M. R. Jones,et al.  Extradural abscess complicating extradural anaesthesia for caesarean section. , 1992, British journal of anaesthesia.

[24]  N. Edwards,et al.  Epidural pethidine and bupivacaine in labour , 1992, Anaesthesia.

[25]  G. Handley,et al.  The Addition of Pethidine to Epidural Bupivacaine in Labour — Effect of Changing Bupivacaine Strength , 1992, Anaesthesia and intensive care.

[26]  J. S. Goldberg,et al.  Use of patient-controlled analgesia to compare the efficacy of epidural to intravenous fentanyl administration. , 1992, Anesthesia and analgesia.

[27]  J. Sutherland,et al.  The Influence of Epidural Pethidine on Shivering during Lower Segment Caesarean Section under Epidural Anaesthesia , 1991, Anaesthesia and intensive care.

[28]  R. Sinatra,et al.  Exogenous opioids in human breast milk and acute neonatal neurobehavior: a preliminary study. , 1990, Anesthesiology.

[29]  F. Reynolds.  Pain relief in labour , 1990, British journal of obstetrics and gynaecology.

[30]  J. Blythe,et al.  Continuous postoperative epidural analgesia for gynecologic oncology patients. , 1990, Gynecologic oncology.

[31]  I. Wilson,et al.  ANALGESIA FOLLOWING EXTRADURAL AND I.M. PETHIDINE IN POST-CAESAREAN SECTION PATIENTS , 1990 .

[32]  M. Paech.  Epidural Pethidine or Fentanyl during Caesarean Section: A Double-Blind Comparison , 1989 .

[33]  A. Sandler,et al.  Respiratory depression and spinal opioids , 1989, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[34]  D. Hartvig,et al.  Patient-controlled analgesia with extradural morphine or pethidine. , 1988, British journal of anaesthesia.

[35]  P. Brownridge,et al.  Epidural Bupivaeaine‐Pethidine Mixture Clinical Experience Using a Low‐dose Combination in Labour , 1988, The Australian & New Zealand journal of obstetrics & gynaecology.

[36]  J. Plummer,et al.  The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: application to morphine and pethidine , 1987, Pain.

[37]  P. Hartvig,et al.  Pharmacokinetics of Epidural Morphine and Meperidine in Humans , 1987, Anesthesiology.

[38]  I. Acalovschi.  Herpes simplex after spinal pethidine , 1986, Anaesthesia.

[39]  R. Robinson,et al.  Hypertension after epidural meperidine , 1985, Canadian Anaesthetists' Society journal.

[40]  G. Berg,et al.  [Influence of the volume of peridural morphine bolus injections on morphine concentration in the cisterna magna of the dog]. , 1985, Der Anaesthesist.

[41]  D. Frewin,et al.  A Comparative Study of Techniques of Postoperative Analgesia following Caesarean Section and Lower Abdominal Surgery , 1985 .

[42]  Cousins Mj,et al.  Intrathecal and epidural administration of opioids , 1984 .

[43]  L. Mather.  Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives , 1983, Clinical pharmacokinetics.

[44]  P. Brownridge,et al.  Respiratory Depression following Accidental Subarachnoid Pethidine , 1983, Anaesthesia and intensive care.

[45]  K. Payne.  Epidural versus intramuscular pethidine in postoperative pain relief. , 1983, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[46]  P. Brownridge.  Epidural and intrathecal opiates for postoperative pain relief , 1983, Anaesthesia.

[47]  D. A. Pybus,et al.  Comparison of four narcotic analgesics for extradural analgesia. , 1982, British journal of anaesthesia.

[48]  L. Mather,et al.  Peridural meperidine in humans: analgesic response, pharmacokinetics, and transmission into CSF. , 1981, Anesthesiology.

[49]  M. Morgan,et al.  EXTRADURAL OPIOIDS FOR POSTOPERATIVE ANALGESIA A double-blind comparison of pethidine, fentanyl and morphine , 1981 .

[50]  H. T. Davenport,et al.  COMPARISON OF EPIDURAL AND INTRAMUSCULAR PETHIDINE FOR ANALGESIA IN LABOUR , 1981, British journal of obstetrics and gynaecology.

[51]  K. Austin,et al.  Relationship Between Blood Meperidine Concentrations and Analgesic Response: A Preliminary Report , 1980, Anesthesiology.

[52]  B. Perriss.  Epidural pethidine in labour , 1980, Anaesthesia.

[53]  M. Rosen,et al.  Neonatal respiration, feeding and neurobehavioural state , 1979 .

[54]  L. Mather,et al.  SELECTIVE SPINAL ANALGESIA , 1979, The Lancet.

[55]  F. Magora,et al.  EPIDURAL MORPHINE IN TREATMENT OF PAIN , 1979, The Lancet.

[56]  H. Szeto,et al.  Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. , 1977, Annals of internal medicine.

[57]  W. S. Koski,et al.  Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence. , 1975, Journal of medicinal chemistry.

[58]  W. Nimmo,et al.  NARCOTIC ANALGESICS AND DELAYED GASTRIC EMPTYING DURING LABOUR , 1975, The Lancet.

[59]  E. Way.  Studies on the local anesthetic properties of isonipecaine. , 1946, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

[60]  O. Schaumann,et al.  Dolantin, ein neuartiges Spasmolytikum und Analgetikum , 1939 .

[61]  V. Suderman,et al.  Early respiratory depression during Caesarean section following epidural meperidine , 1992, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[62]  A. Casy,et al.  Pethidine and Related 4-Phenylpiperidine Analgesics , 1986 .