Effects of antibiotics on the growth, antioxidant capacity, activity of digestive enzymes and serum biochemical indices, liver and intestine morphology of Megalobrama amblycephala fry

This study evaluated the effects of Oxytetracycline (OTC) and Sulfamethoxazole (SMZ) antibiotics on the growth, antioxidant capacity, activity of digestive enzymes and serum biochemical indices, liver and intestine morphology of Megalobrama amblycephala fry. Fish with average initial weights of 3.20 ± 0.09g were fed the control diet, SMZ diet, and OTC diet for 60 days. Compare to the control group, the growth of the Fish fed the antibiotic diet was significantly affected; the immunoglobulin level was significantly lower. Digestive enzymes activity was significantly higher in fish fed SMZ diet than those fed OTC diet. GSH activity was higher in both antibiotic groups, while OTC shows an elevated trend in MDA activity compared to the control group. Histomorphological analysis exhibited changes on liver and intestine tissues of the fish fed the antibiotic diets. These results show that both SMZ and OTC diet impair physiological functions of intestine and Liver and compromise fish immune system. antioxidant capacity, intestinal enzymes, serum biochemical indices, liver and intestine morphology, M. amblycephala

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