Restoring metabolism of myeloid cells reverses cognitive decline in ageing
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I. Weissman | J. Rabinowitz | M. Suematsu | R. Majeti | D. Mochly‐Rosen | Melanie R. McReynolds | Ling Liu | Y. Sugiura | K. Andreasson | F. Longo | Amira Latif‐Hernandez | P. Minhas | E. Gauba | P. Moon | A. Joshi | Joy Q. He | Miles H. Linde | A. Durairaj | Congcong Wang | Qian Wang | Amanda J. Rubin | J. He | Amit U. Joshi | Paras S. Minhas
[1] Hua-Chuan Zhang,et al. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses , 2020, Nature Communications.
[2] Qingyun Li,et al. Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing. , 2019, Journal of visualized experiments : JoVE.
[3] Heng Du,et al. Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease , 2019, Neurobiology of Disease.
[4] S. C. Huang,et al. Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2 , 2018, Immunity.
[5] M. Snyder,et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation , 2018, Nature Immunology.
[6] L. Ferrucci,et al. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty , 2018, Nature Reviews Cardiology.
[7] B. Everts,et al. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. , 2017, Cell metabolism.
[8] M. Heneka,et al. Microglia in Alzheimer's disease. , 2017, The Journal of clinical investigation.
[9] Joshua D. Rabinowitz,et al. Metabolite Spectral Accuracy on Orbitraps. , 2017, Analytical chemistry.
[10] L. O’Neill,et al. Mitochondria are the powerhouses of immunity , 2017, Nature Immunology.
[11] K. Nozaki,et al. Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms , 2017, Science Signaling.
[12] J. Nikolich-Žugich. The twilight of immunity: emerging concepts in aging of the immune system , 2017, Nature Immunology.
[13] D. Balschun,et al. Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs , 2016, Front. Cell. Neurosci..
[14] R. Xavier,et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages , 2016, Cell.
[15] Maxim N. Artyomov,et al. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. , 2016, Cell metabolism.
[16] Bill X. Huang,et al. Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome , 2016, Neurobiology of Aging.
[17] K. Andreasson,et al. Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE2 Signaling in Alzheimer's Disease. , 2016, ACS chemical neuroscience.
[18] M. James,et al. Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease , 2015, Trends in Neurosciences.
[19] Takao Shimizu,et al. A comprehensive quantification method for eicosanoids and related compounds by using liquid chromatography/mass spectrometry with high speed continuous ionization polarity switching. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[20] J. Treanor,et al. A selective prostaglandin E2 receptor subtype 2 (EP2) antagonist increases the macrophage-mediated clearance of amyloid-beta plaques. , 2015, Journal of medicinal chemistry.
[21] L. O’Neill,et al. Metabolic reprogramming in macrophages and dendritic cells in innate immunity , 2015, Cell Research.
[22] C. Cunningham,et al. Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research , 2015, Alzheimer's Research & Therapy.
[23] Abhishek K. Jha,et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. , 2015, Immunity.
[24] H. Brown,et al. Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. , 2015, The Journal of clinical investigation.
[25] U. Lindenberger. Human cognitive aging: Corriger la fortune? , 2014, Science.
[26] Teng Jiang,et al. Microglia in Alzheimer's Disease , 2014, BioMed research international.
[27] Danielle A. Simmons,et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice , 2014, Nature Medicine.
[28] A. Chawla,et al. Metabolic regulation of immune responses. , 2014, Annual review of immunology.
[29] N. Tamaki,et al. Abstract 280: Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage , 2014 .
[30] G. Bitan,et al. A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease , 2013, PloS one.
[31] A. Manning-Boğ,et al. Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia , 2013, The Journal of Neuroscience.
[32] R. Dingledine,et al. Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection. , 2013, Trends in pharmacological sciences.
[33] E. Pearce,et al. Metabolic pathways in immune cell activation and quiescence. , 2013, Immunity.
[34] Liang Zheng,et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α , 2013, Nature.
[35] T. Abel,et al. Aging impairs hippocampus-dependent long-term memory for object location in mice , 2012, Neurobiology of Aging.
[36] Alberto Mantovani,et al. Orchestration of metabolism by macrophages. , 2012, Cell metabolism.
[37] N. Pullen,et al. In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist , 2011, British journal of pharmacology.
[38] J. Kaye,et al. The aging systemic milieu negatively regulates neurogenesis and cognitive function , 2011, Nature.
[39] Garret A. FitzGerald,et al. Prostaglandins and Inflammation , 2011, Arteriosclerosis, thrombosis, and vascular biology.
[40] J. Kaye,et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function , 2011 .
[41] D. Selkoe. Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.
[42] H. D. Vanguilder,et al. Aging alters the expression of neurotransmission‐regulating proteins in the hippocampal synaptoproteome , 2010, Journal of neurochemistry.
[43] C. Brayne. The elephant in the room — healthy brains in later life, epidemiology and public health , 2007, Nature Reviews Neuroscience.
[44] G. Castellani,et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans , 2007, Mechanisms of Ageing and Development.
[45] Jackelyn A. Alva,et al. VE‐cadherin‐CreERT2 transgenic mouse: A model for inducible recombination in the endothelium , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.
[46] K. Druey,et al. Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis , 2005, Science.
[47] Takao Shimizu,et al. A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. , 2005, Analytical biochemistry.
[48] Dayong Wu,et al. Mechanism of age-associated up-regulation in macrophage PGE2 synthesis , 2004, Brain, Behavior, and Immunity.
[49] M. Lynch,et al. Long-term potentiation and memory. , 2004, Physiological reviews.
[50] L. Angelucci,et al. Inhibition of COX‐2 reduces the age‐dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat , 2002, Journal of neuroscience research.
[51] R. Breyer,et al. Prostanoid receptors: subtypes and signaling. , 2001, Annual review of pharmacology and toxicology.
[52] T. Montine,et al. Elevated CSF prostaglandin E2 levels in patients with probable AD. , 1999, Neurology.
[53] T. Teyler. Long-term potentiation and memory. , 1987, International journal of neurology.