The DuraHeart VAD, a magnetically levitated centrifugal pump: the University of Vienna bridge-to-transplant experience.

BACKGROUND The clinical application of the DuraHeart (Terumo Heart Inc, USA) has begun in Europe as a clinical trial of a third-generation implantable centrifugal blood pump. Four successful clinical implants are presented. METHODS AND RESULTS Four male patients had end-stage left heart failure and received a DuraHeart VAD as a left ventricular assist device for bridge-to-transplantation. The pump showed good performance with flow rates of 4.9+/-0.5 L/min after gradual weaning of extracorporeal circulation. The pump flow was then maintained at 6.1+/-0.5, 5.5+/-0.3, 5.5+/-0.1, 5.7+/-0.1, 5.5, 6.4 and 6.5 L/min at the 1st, 4th, 8th, 12th, 16th, 20th and 24th postoperative week, respectively. No significant elevation of mean plasma-free hemoglobin was detected. The patients were discharged on the 18th, 42nd, 41st and 31st postoperative day, respectively, and all were successfully transplanted on the 202nd, 84th, 128th and 96th postoperative day, respectively. At the time of transplant surfaces of the removed pumps were free from thrombus formation, although intraventricular pannus growth was observed around the inflow cannulae in all patients. CONCLUSION The DuraHeart VAD showed stable and sufficient circulatory support for the bridge-to-transplant procedure in this cohort of 4 patients.

[1]  Biswajit Kar,et al.  First clinical use of the redesigned HeartMate II left ventricular assist system in the United States: a case report. , 2004, Texas Heart Institute journal.

[2]  T Akutsu,et al.  Recent progress in the development of Terumo implantable left ventricular assist system. , 1999, ASAIO journal.

[3]  T. Kubo,et al.  Long-Term Prognosis of Dilated Cardiomyopathy Revisited , 2006 .

[4]  Roland Hetzer,et al.  First experiences with a novel magnetically suspended axial flow left ventricular assist device. , 2004, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[5]  H. Schima,et al.  Extensive Coagulation Monitoring in Patients After Implantation of the MicroMed Debakey Continuous Flow Axial Pump , 2004, ASAIO journal.

[6]  A. Besarab,et al.  Detection of Access Strictures and Outlet Stenoses in Vascular Accesses Which Test Is Best? , 1997, ASAIO journal.

[7]  Y. Kagaya,et al.  Poor prognosis of Japanese patients with chronic heart failure following myocardial infarction--comparison with nonischemic cardiomyopathy. , 2005, Circulation journal : official journal of the Japanese Circulation Society.

[8]  S Saito,et al.  Development status of Terumo implantable left ventricular assist system. , 2001, Artificial organs.

[9]  E Wolner,et al.  Lessons learned from the first clinical implants of the DeBakey ventricular assist device axial pump: a single center report. , 2001, The Annals of thoracic surgery.

[10]  G Laufer,et al.  First clinical experience with the DeBakey VAD continuous-axial-flow pump for bridge to transplantation. , 2000, Circulation.

[11]  M. Komeda,et al.  Compact, reliable ventricular assist device as a bridge to recovery or for semipermanent use. , 2001, The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi.

[12]  T Ban,et al.  More Than 1 Year Continuous Operation of a Centrifugal Pump With a Magnetically Suspended Impeller , 1997, ASAIO journal.

[13]  E Wolner,et al.  First experiences with outpatient care of patients with implanted axial flow pumps. , 2001, Artificial organs.

[14]  Satoshi Saito,et al.  First permanent implant of the Jarvik 2000 Heart , 2000, The Lancet.