The aim of the study was to evaluate possibility combining biomarkers and Thrombolisis In Myocardial Infarction score for prediction of the left ventricular systolic dysfunction among patients with ST-segment elevation myocardial infarction. Methods: the results of the study are based on data obtained from a comprehensive survey of 280 patients with ST-segment elevation myocardial infarction, the average age was 60,0 [53,0 ; 64,0] years. All persons were comparable in age, social status, and gender. Results: We found that the basic model was determined by Thrombolisis In Myocardial Infarction score, Se 24,00 % and 86,96 % at Area Under the ROC curve = 0,58 (95% confidence interval 0,515-0,634) with cut off 4 points for the left ventricular systolic dysfunction. To determination of the baseline model with simultaneous three biomarkers (troponin І, metalloproteinase-9, interleukin-6) allowed us to improve the prognosis of left ventricular systolic dysfunction in patients with ST-segment elevation myocardial infarction.