Interferon-inducible antiviral effectors

[1]  Dong-er Zhang,et al.  Different Roles for Two Ubiquitin-like Domains of ISG15 in Protein Modification* , 2008, Journal of Biological Chemistry.

[2]  Dong-er Zhang,et al.  ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response*♦ , 2008, Journal of Biological Chemistry.

[3]  J. Hiscott,et al.  Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates. , 2007, Cell host & microbe.

[4]  Shannon L. Taylor,et al.  Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses , 2007, Cell Host & Microbe.

[5]  Graham R. Foster,et al.  Interferons at age 50: past, current and future impact on biomedicine , 2007, Nature Reviews Drug Discovery.

[6]  C. Cameron,et al.  5'-Triphosphate-Dependent Activation of PKR by RNAs with Short Stem-Loops , 2007, Science.

[7]  G. Kochs,et al.  West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein. , 2007, The Journal of general virology.

[8]  Stefano Volinia,et al.  Interferon modulation of cellular microRNAs as an antiviral mechanism , 2007, Nature.

[9]  M. Hahne,et al.  Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR‐dependent manner , 2007, European journal of immunology.

[10]  R. Silverman Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response , 2007, Journal of Virology.

[11]  R. Silverman,et al.  Small self-RNA generated by RNase L amplifies antiviral innate immunity , 2007, Nature.

[12]  G. Kochs,et al.  Interferon, Mx, and viral countermeasures , 2007, Cytokine & Growth Factor Reviews.

[13]  H. Ploegh,et al.  Screen for ISG15-crossreactive Deubiquitinases , 2007, PloS one.

[14]  Robert Ménard,et al.  Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease , 2007, Archives of Biochemistry and Biophysics.

[15]  J. Casanova,et al.  Human primary immunodeficiencies of type I interferons. , 2007, Biochimie.

[16]  J. Justesen,et al.  The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation. , 2007, Biochimie.

[17]  G. Kochs,et al.  Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene , 2007, Proceedings of the National Academy of Sciences.

[18]  G. Lutfalla,et al.  Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System12 , 2007, The Journal of Immunology.

[19]  Dong-er Zhang,et al.  ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. , 2007, Genes & development.

[20]  K. Knobeloch,et al.  IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses , 2007, Proceedings of the National Academy of Sciences.

[21]  S. Hyberts,et al.  Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. , 2006, Journal of molecular biology.

[22]  T. Morio,et al.  Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. , 2006, Immunity.

[23]  J. Casanova,et al.  Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency , 2006, Science.

[24]  H. Yokosawa,et al.  Negative regulation of protein phosphatase 2Cβ by ISG15 conjugation , 2006, FEBS letters.

[25]  Anantha Marri,et al.  PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons , 2006, Journal of Virology.

[26]  N. Sze,et al.  HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. M. Cameron,et al.  Inhibition of PKR by RNA and DNA viruses. , 2006, Virus research.

[28]  K. Knobeloch,et al.  ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation. , 2006, Cellular and molecular biology.

[29]  S. Paludan,et al.  Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo , 2006, Journal of Virology.

[30]  J. Derisi,et al.  Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant , 2006, PLoS pathogens.

[31]  Dong-er Zhang,et al.  The Interferon-inducible Ubiquitin-protein Isopeptide Ligase (E3) EFP Also Functions as an ISG15 E3 Ligase* , 2006, Journal of Biological Chemistry.

[32]  P. Pitha,et al.  Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15 , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Ming Yan,et al.  Ube1L and Protein ISGylation Are Not Essential for Alpha/Beta Interferon Signaling , 2006, Molecular and Cellular Biology.

[34]  M. Karin,et al.  Immunity by ubiquitylation: a reversible process of modification , 2005, Nature Reviews Immunology.

[35]  H. Yokosawa,et al.  Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. , 2005, Journal of biochemistry.

[36]  R. Schmidt,et al.  Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo , 2005, Journal of Virology.

[37]  R. Gibbs,et al.  Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. , 2005, The Journal of infectious diseases.

[38]  E. Borden,et al.  Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. , 2005, Biochemical and biophysical research communications.

[39]  Arvin C. Dar,et al.  Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR , 2005, Cell.

[40]  Arvin C. Dar,et al.  Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition , 2005, Cell.

[41]  K. Knobeloch,et al.  ISG15, an Interferon-Stimulated Ubiquitin-Like Protein, Is Not Essential for STAT1 Signaling and Responses against Vesicular Stomatitis and Lymphocytic Choriomeningitis Virus , 2005, Molecular and Cellular Biology.

[42]  Steven Gygi,et al.  Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Y. Kitade,et al.  2‐5A induces a conformational change in the ankyrin‐repeat domain of RNase L , 2005, Proteins.

[44]  F. Pociot,et al.  OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes. , 2005, Diabetes.

[45]  F. Pociot,et al.  Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene. , 2005, American journal of human genetics.

[46]  H. Virgin,et al.  Interferon-Inducible Ubiquitin E2, Ubc8, Is a Conjugating Enzyme for Protein ISGylation , 2004, Molecular and Cellular Biology.

[47]  J. MacMicking IFN-inducible GTPases and immunity to intracellular pathogens. , 2004, Trends in immunology.

[48]  Ryan M. O’Connell,et al.  Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection , 2004, The Journal of experimental medicine.

[49]  C. Rice,et al.  PKR-Dependent and -Independent Mechanisms Are Involved in Translational Shutoff during Sindbis Virus Infection , 2004, Journal of Virology.

[50]  R. Krug,et al.  The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein , 2004 .

[51]  H. Nakano,et al.  TRAF Family Proteins Link PKR with NF-κB Activation , 2004, Molecular and Cellular Biology.

[52]  A. Tsubota,et al.  Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection , 2004, Journal of viral hepatitis.

[53]  K. Magnusson,et al.  Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus , 2004, Journal of Virology.

[54]  M. Karin,et al.  The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4 , 2004, Nature.

[55]  K. Kusuhara,et al.  Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis , 2004, Neurology.

[56]  J. Justesen,et al.  Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. , 2004, European journal of biochemistry.

[57]  Kenji Sugiyama,et al.  Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. , 2004, Nucleic acids research.

[58]  R. McLendon,et al.  The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. , 2003, Virology.

[59]  H. Yokosawa,et al.  Extracellular ubiquitin system implicated in fertilization of the ascidian, Halocynthia roretzi: isolation and characterization. , 2003, Developmental biology.

[60]  G. Sen,et al.  Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase. , 2003, Molecular cell.

[61]  H C Thomas,et al.  Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR , 2003, Genes and Immunity.

[62]  B. Williams,et al.  The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture. , 2003, Virology.

[63]  V. Carreño,et al.  Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins. , 2003, The Journal of general virology.

[64]  M. Quintel,et al.  Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. , 2003, Blood.

[65]  Sami Al-Hajjar,et al.  Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency , 2003, Nature Genetics.

[66]  G. Sen,et al.  Crisscross Enzymatic Reaction between the Two Molecules in the Active Dimeric P69 Form of the 2′-5′ Oligodenylate Synthetase* , 2002, The Journal of Biological Chemistry.

[67]  Ding‐Shinn Chen,et al.  The Double-stranded RNA-activated Kinase, PKR, Can Phosphorylate Hepatitis D Virus Small Delta Antigen at Functional Serine and Threonine Residues* , 2002, The Journal of Biological Chemistry.

[68]  M. McNiven,et al.  The Antiviral Dynamin Family Member, MxA, Tubulates Lipids and Localizes to the Smooth Endoplasmic Reticulum* , 2002, The Journal of Biological Chemistry.

[69]  B. Williams,et al.  Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus , 2002, Journal of Virology.

[70]  Dong-er Zhang,et al.  UBP43 (USP18) Specifically Removes ISG15 from Conjugated Proteins* , 2002, The Journal of Biological Chemistry.

[71]  M. Gale,et al.  Expression of human PKR protein kinase in transgenic mice. , 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[72]  K. Klinger,et al.  Germline mutations in the ribonuclease L gene in families showing linkage with HPC1 , 2002, Nature Genetics.

[73]  K. Shimotohno,et al.  Effects of Mutation in Hepatitis C Virus Nonstructural Protein 5A on Interferon Resistance Mediated by Inhibition of PKR Kinase Activity in Mammalian Cells , 2001, Microbiology and immunology.

[74]  Peter Vandenabeele,et al.  Translation Inhibition in Apoptosis , 2001, The Journal of Biological Chemistry.

[75]  M. Grubman,et al.  Inhibition of L-Deleted Foot-and-Mouth Disease Virus Replication by Alpha/Beta Interferon Involves Double-Stranded RNA-Dependent Protein Kinase , 2001, Journal of Virology.

[76]  D. Hober,et al.  Inhibition of coxsackievirus B4 replication in stably transfected cells expressing human MxA protein. , 2001, Virology.

[77]  Fengqin Gao,et al.  Ceramide Regulates Protein Synthesis by a Novel Mechanism Involving the Cellular PKR Activator RAX* , 2001, The Journal of Biological Chemistry.

[78]  C. Bréchot,et al.  Inhibition of Hepatitis B Virus Replication by the Interferon-Inducible MxA Protein , 2001, Journal of Virology.

[79]  R. Krug,et al.  Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)‐induced ubiquitin‐like ISG15 protein , 2001, The EMBO journal.

[80]  R. Fairchild,et al.  Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR1 , 2000, The Journal of Immunology.

[81]  S. Nanduri,et al.  A dynamically tuned double‐stranded RNA binding mechanism for the activation of antiviral kinase PKR , 2000, The EMBO journal.

[82]  N. Sonenberg,et al.  The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus , 2000, Journal of Virology.

[83]  M. Hijikata,et al.  Identification of a Single Nucleotide Polymorphism in the MxA Gene Promoter (G/T at nt –88) Correlated with the Response of Hepatitis C Patients to Interferon , 2000, Intervirology.

[84]  M. Esteban,et al.  The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-α receptors , 2000, Oncogene.

[85]  C. A. de la Motte,et al.  Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase1 , 2000, The Journal of Immunology.

[86]  Adolfo Garcia-Sastre,et al.  Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication , 2000, Journal of Virology.

[87]  E. Meurs,et al.  PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex , 2000, Molecular and Cellular Biology.

[88]  P. Roberts,et al.  Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. , 2000, Immunity.

[89]  R. Silverman,et al.  Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[90]  A. Lau,et al.  Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[91]  V. Carreño,et al.  In vivo and in vitro induction of MxA protein in peripheral blood mononuclear cells from patients chronically infected with hepatitis C virus. , 1999, The Journal of infectious diseases.

[92]  D. Rebouillat,et al.  The human 2',5'-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties. , 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[93]  G. Kochs,et al.  Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[94]  H. Atkins,et al.  Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR* , 1999, The Journal of Biological Chemistry.

[95]  B. Williams,et al.  Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays , 1998 .

[96]  B. Williams,et al.  Structure of the double‐stranded RNA‐binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA‐mediated activation , 1998, The EMBO journal.

[97]  G. Sen,et al.  PACT, a protein activator of the interferon‐induced protein kinase, PKR , 1998, The EMBO journal.

[98]  A. Hinnebusch,et al.  Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2 , 1998, Molecular and Cellular Biology.

[99]  D. Proud,et al.  Activation of Antiviral Protein Kinase Leads to Immunoglobulin E Class Switching in Human B Cells , 1998, Journal of Virology.

[100]  Abhrajyoti Ghosh,et al.  Enzymatic Activity of 2′–5′-Oligoadenylate Synthetase Is Impaired by Specific Mutations that Affect Oligomerization of the Protein* , 1997, The Journal of Biological Chemistry.

[101]  R. Silverman,et al.  Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L , 1997, The EMBO journal.

[102]  N. Sonenberg,et al.  Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR , 1997, Journal of virology.

[103]  A. Hinnebusch,et al.  Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR , 1996, Molecular and cellular biology.

[104]  S. Ramanujam,et al.  In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine. , 1996, Journal of immunology.

[105]  C. Samuel,et al.  Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase. , 1996, Virology.

[106]  A. Haas,et al.  Conjugation of the 15-kDa Interferon-induced Ubiquitin Homolog Is Distinct from That of Ubiquitin (*) , 1996, The Journal of Biological Chemistry.

[107]  A. Aguzzi,et al.  Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase. , 1995, The EMBO journal.

[108]  G. Kochs,et al.  Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1 , 1995, Journal of virology.

[109]  Aseem Kumar,et al.  Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[110]  M Aguet,et al.  Functional role of type I and type II interferons in antiviral defense. , 1994, Science.

[111]  R. Silverman,et al.  Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase. , 1994, The Journal of biological chemistry.

[112]  S. B. Lee,et al.  The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. , 1994, Virology.

[113]  P. Terpstra,et al.  A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[114]  K. Loeb,et al.  The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins. , 1992, The Journal of biological chemistry.

[115]  J. Osinga,et al.  A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. , 1992, Cancer research.

[116]  R. Sperling,et al.  Possible involvement of (2'5')oligoadenylate synthetase activity in pre-mRNA splicing. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[117]  P. Torrence,et al.  2',5'-oligoadenylates inhibit relaxation of supercoiled DNA by calf thymus DNA topoisomerase I. , 1991, Journal of interferon research.

[118]  A. Hovanessian,et al.  Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon. , 1990, The Journal of biological chemistry.

[119]  I. Kerr,et al.  Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon , 1990, Cell.

[120]  M. Noteborn,et al.  Transgenic mice with intracellular immunity to influenza virus , 1990, Cell.

[121]  Å. Lernmark,et al.  Association of IDDM and Attenuated Response of 2′,5′-Oligoadenylate Synthetase to Yellow Fever Vaccine , 1989, Diabetes.

[122]  M. Aebi,et al.  cDNA structures and regulation of two interferon-induced human Mx proteins , 1989, Molecular and cellular biology.

[123]  G. Huez,et al.  cDNA cloning and assignment to chromosome 21 ofIFI-78K gene, the human equivalent of murineMx gene , 1988, Somatic cell and molecular genetics.

[124]  B. Korant,et al.  Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence. , 1986, The Journal of biological chemistry.

[125]  P. Lengyel,et al.  Interferon action: RNA cleavage pattern of a (2'-5')oligoadenylate--dependent endonuclease. , 1981, Science.

[126]  J. Skehel,et al.  Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease , 1981, Nature.

[127]  I. Gresser,et al.  Host gene influences sensitivity to interferon action selectively for influenza virus , 1980, Nature.

[128]  I. Gresser,et al.  Genetically determined, interferon-dependent resistance to influenza virus in mice , 1979, The Journal of experimental medicine.

[129]  M. Clemens,et al.  Inhibition of protein synthesis by double-stranded RNA in reticulocyte lysates: evidence for activation of an endoribonuclease. , 1978, Biochemical and biophysical research communications.

[130]  B. Williams,et al.  Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts , 1978, Cell.

[131]  I. Kerr,et al.  Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA , 1977, Nature.

[132]  W. K. Roberts,et al.  Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis , 1976, Nature.

[133]  J. Lindenmann,et al.  Inheritance of Resistance to Influenza Virus in Mice.∗ , 1964, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[134]  J. Lindenmann Resistance of mice to mouse-adapted influenza A virus. , 1962, Virology.

[135]  H. Yokosawa,et al.  Detection and analysis of protein ISGylation. , 2008, Methods in molecular biology.

[136]  H. Ploegh,et al.  Screen for ISG 15-crossreactive Deubiquitinases , 2007 .

[137]  K. Nilsson,et al.  IFN-γ-induced upregulation of Fcγ-receptor-i during activation of monocytic cells requires the PKR and NFκB pathways , 2007 .

[138]  F. Pociot,et al.  OAS 1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes , 2005 .

[139]  R. Silverman,et al.  Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L. , 2002, Viral immunology.

[140]  H. Tsutsumi [Viral infection]. , 2002, Nihon rinsho. Japanese journal of clinical medicine.

[141]  P. Vandenabeele,et al.  Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. , 2001, The Journal of biological chemistry.

[142]  E. Park,et al.  Double‐stranded RNA–activated protein kinase is required for the LPS‐induced activation of STAT1 inflammatory signaling in rat brain glial cells , 2005, Glia.