Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells

[1]  Y. T. Lee,et al.  HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts , 2016, PloS one.

[2]  Matthew C. Canver,et al.  Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin , 2016, Science.

[3]  Y. T. Lee,et al.  Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping. , 2015, Blood.

[4]  Y. T. Lee,et al.  Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts , 2014, PloS one.

[5]  Y. T. Lee,et al.  LIN28A Expression Reduces Sickling of Cultured Human Erythrocytes , 2014, PloS one.

[6]  S. Luo,et al.  Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study , 2014, Nature Methods.

[7]  Ana Kozomara,et al.  miRBase: annotating high confidence microRNAs using deep sequencing data , 2013, Nucleic Acids Res..

[8]  Y. T. Lee,et al.  LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. , 2013, Blood.

[9]  Y. T. Lee,et al.  A Synthetic Model of Human Beta-Thalassemia Erythropoiesis Using CD34+ Cells from Healthy Adult Donors , 2013, PloS one.

[10]  R. Bak,et al.  Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors. , 2013, RNA.

[11]  Stefan L Ameres,et al.  Long-term, efficient inhibition of microRNA function in mice using rAAV vectors , 2012, Nature Methods.

[12]  Dimitrios Iliopoulos,et al.  Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms , 2011, Cell.

[13]  Cong Peng,et al.  Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing , 2011, Science.

[14]  Ana Kozomara,et al.  miRBase: integrating microRNA annotation and deep-sequencing data , 2010, Nucleic Acids Res..

[15]  W. Filipowicz,et al.  The widespread regulation of microRNA biogenesis, function and decay , 2010, Nature Reviews Genetics.

[16]  T. Townes,et al.  KLF1 regulates BCL11A expression and γ- to β-globin gene switching , 2010, Nature Genetics.

[17]  S. Orkin,et al.  Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. , 2010, Genes & development.

[18]  G. Daley,et al.  Lin28: A MicroRNA Regulator with a Macro Role , 2010, Cell.

[19]  F. Marincola,et al.  Let-7 microRNAs are developmentally regulated in circulating human erythroid cells , 2009, Journal of Translational Medicine.

[20]  S. Goh,et al.  Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. , 2009, Blood.

[21]  Y. T. Lee,et al.  Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. , 2009, Blood.

[22]  P. Ridker,et al.  Genome-wide association studies identify novel loci associated with age at menarche and age at natural menopause , 2009, Nature Genetics.

[23]  D. Gudbjartsson,et al.  Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche , 2009, Nature Genetics.

[24]  H. Iba,et al.  Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells , 2009, Nucleic acids research.

[25]  J. Hirschhorn,et al.  Supporting Online Material Materials and Methods Figs. S1 to S10 Tables S1 to S7 References Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-specific Repressor Bcl11a , 2022 .

[26]  F. Slack,et al.  The let-7 family of microRNAs. , 2008, Trends in cell biology.

[27]  C. Gieger,et al.  Identification of ten loci associated with height highlights new biological pathways in human growth , 2008, Nature Genetics.

[28]  C. Burge,et al.  Identification of let-7-regulated oncofetal genes. , 2008, Cancer research.

[29]  Shulan Tian,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[30]  Stijn van Dongen,et al.  miRBase: tools for microRNA genomics , 2007, Nucleic Acids Res..

[31]  E. Kistner,et al.  Let-7 expression defines two differentiation stages of cancer , 2007, Proceedings of the National Academy of Sciences.

[32]  A. Harel-Bellan,et al.  Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. , 2007, Genes & development.

[33]  Stijn van Dongen,et al.  miRBase: microRNA sequences, targets and gene nomenclature , 2005, Nucleic Acids Res..

[34]  M. Cam,et al.  A newly discovered human alpha-globin gene. , 2005, Blood.

[35]  Y. Furukawa,et al.  A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression. , 2003, Blood.

[36]  Jeffery L. Miller,et al.  Fetal and adult hemoglobin production during adult erythropoiesis: coordinate expression correlates with cell proliferation. , 2002, Blood.

[37]  B. Reinhart,et al.  Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA , 2000, Nature.

[38]  B. Reinhart,et al.  The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans , 2000, Nature.

[39]  G. Ruvkun,et al.  Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans , 1993, Cell.

[40]  V. Ambros,et al.  The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.

[41]  D. Linch,et al.  Expression of the human carbonic anhydrase I gene is activated late in fetal erythroid development and regulated by stage‐specific trans‐acting factors , 1990, British journal of haematology.

[42]  J. Cartron,et al.  Biosynthesis of blood group I antigens. Identification of a UDP-GlcNAc:GlcNAc beta 1-3Gal(-R) beta 1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase in hog gastric mucosa. , 1984, The Journal of biological chemistry.

[43]  D. Strachan,et al.  Genetic variation in LIN28B is associated with the timing of puberty. , 2009, Nature genetics.

[44]  Sam Griffiths-Jones,et al.  The microRNA Registry , 2004, Nucleic Acids Res..