Ulcerative Colitis Remission after Renal Transplantation: Two Case Reports

Background and Aims: The combination of ulcerative colitis (UC) and end stage renal disease (ESRD) is uncommon. Immunosuppressive drugs that are used after kidney transplantation are considered as effective therapeutic alternatives for UC. We report two renal transplant recipients with long term refractory UC prior to kidney transplantation and confirmed by histological examination, cured following transplantation. Clinical remission occurred immediately after kidney transplantation, and they had no symptoms of UC during 3 and 8 years of follow up periods. Their immunosuppression regimens were cyclosporine, mycophenolate mofetil / azathioprine and prednisone. In conclusion, kidney transplantation with immunosuppression leads to clinical remission in patients with the inflammatory bowel diseases and ESRD.

[1]  J. Onken,et al.  Inflammatory bowel disease following solid organ transplantation. , 2008, Clinical immunology.

[2]  M. Halim,et al.  De-novo [corrected] post renal transplantation inflammatory bowel disease. , 2008, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.

[3]  F. Rodríguez-Moranta,et al.  Estado actual del tratamiento de la enfermedad inflamatoria intestinal , 2007 .

[4]  K. Johny,et al.  De novo Crohn's disease in a renal transplant recipient. , 2007, Transplantation proceedings.

[5]  F. Fein,et al.  Treatment of ulcerative colitis refractory to steroid therapy by oral microemulsion cyclosporine (neoral) , 2006, Inflammatory bowel diseases.

[6]  B. Maes,et al.  Crohn's‐like changes in the colon due to mycophenolate? , 2005, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[7]  C. Scudamore,et al.  CASE REPORT: Post-Liver Transplant Crohn's Disease: Graft Tolerance but Not Self-Tolerance? , 2002, Digestive Diseases and Sciences.

[8]  J. Kleibeuker,et al.  Inflammatory bowel disease after liver transplantation: the effect of different immunosuppressive regimens , 2003, Alimentary pharmacology & therapeutics.

[9]  E. Cabré,et al.  Azathioprine without oral ciclosporin in the long‐term maintenance of remission induced by intravenous ciclosporin in severe, steroid‐refractory ulcerative colitis , 2002, Alimentary pharmacology & therapeutics.

[10]  A. Hibbs,et al.  Ulcerative colitis in a renal transplant patient with previous Goodpasture disease , 2001, Pediatric Nephrology.

[11]  W. Reinisch,et al.  Is mycophenolate mofetil an effective alternative in azathioprine-intolerant patients with chronic active Crohn's disease? , 2001, American Journal of Gastroenterology.

[12]  A. Burroughs,et al.  Ulcerative colitis has an aggressive course after orthotopic liver transplantation for primary sclerosing cholangitis , 1998, Gut.

[13]  Randall G. Lee,et al.  A case series of transplant recipients who despite immunosuppression developed inflammatory bowel disease. , 1997, The American journal of gastroenterology.