Prevalence of thyroid hormone autoantibodies in healthy subjects

OBJECTIVE The prevalence of thyroid hormone autoantibodies in patients with thyroid disorders has been well described, although the results have been variable. However, the prevalence of thyroid hormone autoantibodies in apparently healthy subjects remains unknown and its determination was the main objective of this study. SUBJECTS AND METHODS Sera obtained from 880 healthy subjects (365 men and 515 women) were examined for thyroid hormone autoantibodies by immune precipitation using radiolabelled thyroid hormones or thyroid hormone analogues.

[1]  M. Nahm,et al.  Endogenous antibodies that interfere with thyroxine fluorescence polarization assay but not with radioimmunoassay or EMIT. , 1993, Clinical chemistry.

[2]  E. Ishikawa,et al.  Use of inactive β‐d‐galactosidase for elimination of interference by anti‐β‐d‐galactosidase antibodies in immune complex transfer enzyme immunoassay for anti‐thyroglobulin igg in serum using β‐d‐galactosidase from escherichia coli as label , 1991 .

[3]  M. Haniuda,et al.  Anti-triiodothyronine autoantibodies in a euthyroid woman: confirmation of immunoglobulin G antibodies employing protein A column chromatography. , 1991, Acta endocrinologica.

[4]  M. Iitaka,et al.  The mechanism for the discrepancy between serum total and free thyroxine values induced by autoantibodies: report on two patients with Graves' disease. , 1990, Acta endocrinologica.

[5]  R. Ekins.  Measurement of free hormones in blood. , 1990, Endocrine reviews.

[6]  K. Miura,et al.  Effect of 8-anilino-1-naphthalene sulfonic acid (ANS) on the interaction between thyroid hormone and anti-thyroid hormone antibodies. , 1989, Clinica chimica acta; international journal of clinical chemistry.

[7]  P. Byfield,et al.  The role of thyroid hormone autoantibodies in serum transport. , 1989, Acta endocrinologica.

[8]  F. Trimarchi,et al.  Circulating thyroid hormone autoantibodies , 1987, Journal of endocrinological investigation.

[9]  K. Okuda,et al.  Genetic control of the production of anti-thyroid hormone antibodies in mice immunized with human thyroglobulin. , 1986, Immunological investigations.

[10]  K. Miura,et al.  Autoantibodies against thyroid hormones or iodothyronine. Implications in diagnosis, thyroid function, treatment, and pathogenesis. , 1985, Annals of internal medicine.

[11]  J. Midgley,et al.  Comprehensive study of a thyroxin-analog-based assay for free thyroxin ("Amerlex FT4"). , 1985, Clinical chemistry.

[12]  N. Emoto,et al.  Triiodothyronine binding immunoglobulin in a euthyroid man without apparent thyroid disease; its properties and effects on triiodothyronine metabolism. , 1985, Acta endocrinologica.

[13]  K. Miura,et al.  Age- and sex-related differences of serum thyroxine binding globulin (TBG) in healthy subjects. , 1983, Acta endocrinologica.

[14]  J. Beilby,et al.  Interference in radioimmunoassay of total serum thyroxin and free thyroxin due to thyroxin-binding autoantibodies. , 1983, Clinical chemistry.

[15]  P. Byfield,et al.  Studies on the antigenicity of human thyroglobulin. , 1983, Life sciences.

[16]  J. Midgley,et al.  AN IMPROVED METHOD FOR THE ESTIMATION OF RELATIVE BINDING CONSTANTS OF T4 AND ITS ANALOGUES WITH SERUM PROTEINS , 1982, Clinical endocrinology.

[17]  A. Vermeulen,et al.  Monoclonal triiodothyronine (T3)-binding immunoglobulins in a euthyroid woman. , 1982, Clinica chimica acta; international journal of clinical chemistry.

[18]  C. J. Pearce,et al.  AUTOANTIBODIES TO THYROGLOBULIN CROSS REACTING WITH IODOTHYRONINES , 1981, Clinical endocrinology.

[19]  J. Konishi,et al.  Anti-thyroxine and anti-triiodothyronine antibodies in three cases of Hashimotos thyroiditis. , 1978, Acta endocrinologica.

[20]  K. Iimori,et al.  VARIOUS AUTOANTIBODIES IN HASHIMOT0'S THYROIDITIS , 1978 .

[21]  M. Atassi,et al.  Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis. , 1977, The Biochemical journal.

[22]  A. von zur Mühlen,et al.  Anti Thyroid Hormone Autoantibodies under Experimental and Clinical Conditions , 1977, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[23]  F. Karlsson,et al.  Hypothyroidism due to thyroid-hormone-binding antibodies. , 1977, The New England journal of medicine.

[24]  A. Burger,et al.  Detection of human anti-thyroxine and anti-triiodothyronine antibodies in different thyroid conditions. , 1975, The Journal of clinical endocrinology and metabolism.

[25]  Y. Ochi,et al.  Immunological analysis of abnormal binding of thyroid hormone in the gamma globulin. , 1972, The Journal of clinical endocrinology and metabolism.

[26]  H. Blumenthal,et al.  Abnormal binding of thyroid hormone in sera from patients with Hashimoto's disease. , 1967, The Journal of clinical endocrinology and metabolism.

[27]  R. Mellinger,et al.  Effects of oral administration of estrogens on the 17-ketosteroid excretion of virilized women. , 1961, The Journal of clinical endocrinology and metabolism.

[28]  J. E. Rall,et al.  An unusual instance of thyroxine-binding by human serum gamma globulin. , 1956, The Journal of clinical endocrinology and metabolism.