Autologous blood donations prior to elective cardiac surgery. Safety and effect on subsequent blood use.

Blood transfusions are frequently necessary for patients having open heart surgery. Although autologous blood is free of such risks as transfusion-transmitted diseases, the safety and effectiveness of autologous donations by cardiac patients are debated. We analyzed the records of 291 consecutive patients undergoing elective open heart surgery. One hundred seven (36.8%) donated between 1 and 6 U of autologous blood (mean, 3.0 +/- 1.5 U) before undergoing surgery. First-time elective coronary artery bypass surgery was the most common indication for autologous donation (90.6% of autologous donors). Problems following donations were infrequent (2 of 326 donations) and without long-term consequences. Among patients having coronary artery bypass surgery who donated autologous blood, 27% required homologous blood transfusions as compared with 82% of other patients undergoing the same procedure. We conclude that autologous blood donations are safe for patients with cardiac disease and effective in significantly reducing homologous blood needs in patients undergoing elective coronary artery bypass surgery.

[1]  T. Killip.  Twenty years of coronary bypass surgery. , 1988, The New England journal of medicine.

[2]  J. Spivak,et al.  Effect of repeated whole blood donations on serum immunoreactive erythropoietin levels in autologous donors. , 1988, JAMA.

[3]  R. Thurer.  Blood conservation in cardiac operations. , 1988, Mayo Clinic proceedings.

[4]  H. Schaff,et al.  Effect of blood conservation efforts in cardiac operations at the Mayo Clinic. , 1988, Mayo Clinic proceedings.

[5]  W. Daggett,et al.  Transfusion of predonated autologous blood in elective cardiac surgery. , 1987, The Annals of thoracic surgery.

[6]  J. Ward,et al.  Risk of human immunodeficiency virus infection from blood donors who later developed the acquired immunodeficiency syndrome. , 1987, Annals of internal medicine.

[7]  S. Gayet,et al.  Post‐Transfusion Non‐A, Non‐B Hepatitis after Cardiac Surgery , 1986, Vox sanguinis.

[8]  R. Faust.  Technical Manual of the American Association of Blood Banks , 1986 .

[9]  E. E. Glazer,et al.  Utilization and effectiveness of a hospital autologous preoperative blood donor program , 1986, Transfusion.

[10]  H. Jaffe,et al.  Transfusion-associated acquired immunodeficiency syndrome in the United States. , 1985, JAMA.

[11]  L. Mickleborough,et al.  Limitations of blood conservation. , 1984, The Journal of thoracic and cardiovascular surgery.

[12]  W. Daggett,et al.  The efficacy of postoperative autotransfusion in patients undergoing cardiac operations. , 1983, The Annals of thoracic surgery.

[13]  L. Gray,et al.  Intraoperative Autotransfusion: Experience in 725 Consecutive Cases , 1983, Annals of surgery.

[14]  T. Salerno,et al.  The cell saver during cardiac surgery: does it save? , 1982, The Annals of thoracic surgery.

[15]  L. Grillner,et al.  Non-A, non-B hepatitis after open-heart surgery in Sweden. , 1982, Scandinavian journal of infectious diseases.

[16]  A. Cordell,et al.  An appraisal of blood salvage techniques in vascular and cardiac operations. , 1981, The Annals of thoracic surgery.

[17]  W. Moores,et al.  Blood conservation techniques. , 1981, The Annals of thoracic surgery.

[18]  R. Malchus,et al.  Hepatitis after Cardiosurgery. Frequency and Causes , 1980, The Thoracic and cardiovascular surgeon.

[19]  W. Bayer,et al.  The use of blood and blood components in 1,769 patients undergoing open-heart surgery. , 1980, The Annals of thoracic surgery.

[20]  F. Loop,et al.  Autotransfusion following cardiac operations: a randomized, prospective study. , 1979, The Annals of thoracic surgery.

[21]  V. Gott,et al.  Routine use of autotransfusion following cardiac surgery: experience in 700 patients. , 1979, The Annals of thoracic surgery.

[22]  H. Ohlmeier,et al.  [Autologous blood donation and transfusion in cardiosurgical high risk patients (author's transl)]. , 1978, Thoraxchirurgie, vaskulare Chirurgie.

[23]  A. Fleming,et al.  Development of a practical autologous blood transfusion program. , 1977, The American surgeon.

[24]  J. Matloff,et al.  Autologous Blood Transfusion in Coronary Artery Bypass Surgery , 2003, Transfusion.

[25]  R. C. Dennis,et al.  Autologous blood transfusion during cardiopulmonary bypass. , 1976, Chest.

[26]  H. Silver.  Banked and Fresh Autologous Blood in Cardiopulmonary Bypass Surgery , 2003, Transfusion.

[27]  L. Cohn,et al.  The effects of phlebotomy, hemodilution and autologous transfusion on systemic oxygenation and whole blood utilization in open heart surgery. , 1975, Chest.

[28]  D. McGoon,et al.  Failure of transfusion of autologous whole blood to reduce banked-blood requirements in open-heart surgical patients. , 1975, The Journal of thoracic and cardiovascular surgery.

[29]  J. Greenberg,et al.  The Use of Autologous Blood in Open‐Heart Surgery , 1974, Transfusion.

[30]  N. Mills,et al.  Fresh Autologous Blood Transfusions with Extracorporeal Circulation , 1973, Annals of surgery.

[31]  C. Valeri,et al.  Rejuvenation and freezing of outdated stored human red cells. , 1972, The New England journal of medicine.

[32]  M. Buckley,et al.  Transfusion of fresh autologous blood in open-heart surgery. A method for reducing bank blood requirements. , 1972, The Journal of thoracic and cardiovascular surgery.

[33]  A. D. Clarke,et al.  Reduction of blood loss by restoration of platelet levels using fresh autologous blood after cardiopulmonary bypass , 1972, Thorax.

[34]  R. Hardesty,et al.  A technique for the use of autologous fresh blood during open-heart surgery. , 1968, The Journal of thoracic and cardiovascular surgery.

[35]  H. Awwad,et al.  Plasma protein kinetics of the early transcapillary refill after hemorrhage in man. , 1967, Surgery, gynecology & obstetrics.

[36]  J. Moncrief,et al.  Efficacy of buffered saline as the sole replacement fluid following acute measured hemorrhage in man. , 1967, The Journal of trauma.