The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures.

[1]  R. Rosenthal,et al.  Use of γ-(4-Nitrobenzyl)pyridine as Analytical Reagent for Ethylenimines and Alkylating Agents , 1955 .

[2]  B. Ames,et al.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Ashby,et al.  Saccharin: an epigenetic carcinogen/mutagen? , 1978, Food and cosmetics toxicology.

[4]  G. Williams,et al.  The decision-point approach for systematic carcinogen testing. , 1981, Food and cosmetics toxicology.

[5]  W. Suter,et al.  Genotoxicity evaluation of cyclosporin A, a new immunosuppressive agent. , 1982, Mutation research.

[6]  J. Ashby,et al.  Lack of mutagenicity to S. typhimurium of neopentyl bromide and pentaerythrityl tetrachloride: relation to chemical structure. , 1984, Mutation research.

[7]  J. Ashby Fundamental structural alerts to potential carcinogenicity or noncarcinogenicity. , 1985, Environmental mutagenesis.

[8]  R. Tennant,et al.  Comparison of multiple parameters of rodent carcinogenicity and in vitro genetic toxicity. , 1986, Environmental mutagenesis.

[9]  D. Brusick,et al.  The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program. , 1986, Mutation research.

[10]  International commission for protection against environmental mutageus and carcinogeus: The need for biological risk assessment in reaching decisions about carcinogens , 1987 .

[11]  D. Clayson ICPEMC publication no. 13 the need for biological risk assessment in reaching decisions about carcinogens (MTR07214) , 1987 .

[12]  R. Cattley,et al.  Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats. , 1988, Cancer research.

[13]  R. Tennant,et al.  Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. , 1988, Mutation research.

[14]  M. Shelby The genetic toxicity of human carcinogens and its implications. , 1988, Mutation research.

[15]  T. Goldsworthy,et al.  Potential role of alpha-2 mu-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane. , 1988, Toxicology and applied pharmacology.

[16]  J. French,et al.  Development and validation of a cellular transplant model for leukemia in Fischer rats: a short-term assay for potential anti-leukemic chemicals. , 1989, Leukemia research.

[17]  C. F. Wilkinson,et al.  Thyroid follicular cell carcinogenesis. , 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[18]  D. Marzin,et al.  Genotoxic activity of nickel subsulphide α-Ni 3S2 , 1990 .

[19]  J. Ashby,et al.  Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. , 1990, Mutagenesis.

[20]  M C Cimino,et al.  The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. , 1990, Mutation research.

[21]  I. Issemann,et al.  Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.

[22]  B. Butterworth,et al.  Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenic potential. , 1990, Mutation research.

[23]  E Zeiger,et al.  Activity of human carcinogens in the Salmonella and rodent bone-marrow cytogenetics tests. , 1990, Mutation research.

[24]  H. Vainio,et al.  Carcinogenicity evaluations and ongoing studies: the IARC databases. , 1991, Environmental health perspectives.

[25]  Perspectives on the risk assessment for nongenotoxic carcinogens and tumor promoters. , 1991 .

[26]  G. Clark,et al.  Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. , 1991, Cancer research.

[27]  L. Bernstein,et al.  Target organs in chronic bioassays of 533 chemical carcinogens. , 1991, Environmental health perspectives.

[28]  R. Tennant,et al.  Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. , 1991, Mutation research.

[29]  S Parodi,et al.  Are genotoxic carcinogens more potent than nongenotoxic carcinogens? , 1991, Environmental health perspectives.

[30]  R. Tennant,et al.  Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. , 1991, Mutation research.

[31]  J Ashby,et al.  Consideration of CASE predictions of genotoxic carcinogenesis for omeprazole, methapyrilene and azathioprine. , 1992, Mutation research.

[32]  Mutagenicity of benzo(a)pyrenyl‐1‐sulfate in the Ames test , 1992, Environmental and molecular mutagenesis.

[33]  D. Gandalovicová,et al.  Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice. , 1992, Mutation research.

[34]  J. Barrett,et al.  Mechanisms of multistep carcinogenesis and carcinogen risk assessment. , 1993, Environmental health perspectives.