Networkcentric healthcare and bioinformatics: Unified operations within three domains of knowledge

Bioinformatics is a rapidly developing field of quantitative biomedical research with the potential to transform the three principle domains within healthcare operations of research, clinical practice and administration. Presently, a significant part of bioinformatics research concentrates on genomics and proteomics. Despite growing clinical enthusiasm for the discoveries and creation of new information and knowledge that such research brings, current results are still outside the daily clinical reality. As a measure to close the gap and integrate bioinformatics into the rest of the healthcare domains, the authors propose a networkcentric approach. Based on operations within the unified space created by the overlap of three domains of knowledge, networkcentric healthcare operations support free information flow among all constituents (actors) within the healthcare space, rapid generation and exchange of pertinent knowledge, as well as enhanced awareness of the significance and practical implementation of new discoveries within specialized fields of biomedicine (e.g. bioinformatics). Healthcare networkcentricity will also facilitate conversion of information into readily accessible knowledge, accelerate translation of that knowledge into clinical practice, and reduce the stress of information overload. Changes in the use of Information/Computer/Communication Technologies (IC^2T) and enhanced efficiency of Decision/Executive Support Systems (DSS/ESS) are pivotal to the success of the networkcentric approach as discussed in the paper.

[1]  E. Weibel,et al.  A principle for counting tissue structures on random sections. , 1962, Journal of applied physiology.

[2]  I Masic Actual problems in medical informatics. , 1999, Medicinski arhiv.

[3]  Victor Maojo,et al.  Viewpoint Paper: Bioinformatics and Medical Informatics: Collaborations on the Road to Genomic Medicine? , 2003, J. Am. Medical Informatics Assoc..

[4]  R. Crystal,et al.  Progress in human gene therapy. , 1996, Kidney international.

[5]  A. V. D. Ven,et al.  Perspectives on organization design and behavior , 1983 .

[6]  P. Carroll,et al.  Detection of prostate cancer using serum proteomics pattern in a histologically confirmed population , 2004 .

[7]  L. Sokoloff,et al.  An adaptation of the nitrous oxide method to the study of the cerebral circulation in children; normal values for cerebral blood flow and cerebral metabolic rate in childhood. , 1957, The Journal of clinical investigation.

[8]  Mark H Ebell,et al.  Information mastery: integrating continuing medical education with the information needs of clinicians. , 2003, The Journal of continuing education in the health professions.

[9]  David Lopez-Lee,et al.  Indiscriminate Data Aggregations in Meta-Analysis , 2002, Evaluation review.

[10]  Irvine Loudon,et al.  Western medicine : an illustrated history , 1997 .

[11]  G R Bergus,et al.  Using the World Wide Web to answer clinical questions: how efficient are different methods of information retrieval? , 1999, The Journal of family practice.

[12]  A J Sefton,et al.  Healthcare and the information age: implications for medical education , 1998, The Medical journal of Australia.

[13]  Domenico M. Pisanelli,et al.  An ontological approach to evidence-based medicine and meta-analysis , 2003, MIE.

[14]  F. Pérez-López,et al.  An evaluation of the contents and quality of menopause information on the World Wide Web. , 2004, Maturitas.

[15]  K. Conlon,et al.  Surgical informatics on the Internet: any improvement? , 2003, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[16]  C. Newell,et al.  The balancing act: key issues in the lives of women general practitioners in Australia , 2002, The Medical journal of Australia.

[17]  Paul Kellam,et al.  Virus bioinformatics: databases and recent applications. , 2002, Applied bioinformatics.

[18]  Wilburt C. Davison,et al.  Future of Medical Education , 1941, Journal. Association of American Medical Colleges.

[19]  Ely Laureano Paiva,et al.  Integrating different types of knowledge: an empirical investigation , 2003 .

[20]  Johannes Jacobus Krabbendam,et al.  Enabling innovative healthcare delivery through the use of the focused factory model: the case of the spine clinic of the future , 2005 .

[21]  A R Jadad,et al.  Rating health information on the Internet: navigating to knowledge or to Babel? , 1998, JAMA.

[22]  S Maloney,et al.  Accessibility, nature and quality of health information on the Internet: a survey on osteoarthritis. , 2005, Rheumatology.

[23]  C. Bostock,et al.  Molecular Biology and the Clinician , 1982, Scottish medical journal.

[24]  N. Dluhy,et al.  Knowledge acquisition, synthesis, and validation: a model for decision support systems. , 2004, Journal of advanced nursing.

[25]  R L Harris,et al.  Visual scanning behavior and mental workload in aircraft pilots. , 1982, Aviation, space, and environmental medicine.

[26]  E. Hundert,et al.  Defining and assessing professional competence. , 2002, JAMA.

[27]  Poul Kruhøffer,et al.  Studies on the Lung Diffusion Coefficient for Carbon Monoxide in Normal Human Subjects by means of C14O. , 1954 .

[28]  J. Åqvist,et al.  Computational prediction of structure, substrate binding mode, mechanism, and rate for a malaria protease with a novel type of active site. , 2004, Biochemistry.

[29]  J Zvarova,et al.  Medical informatics--an interdisciplinary approach. , 1996, Medicinski arhiv.

[30]  Kathleen N. Lohr,et al.  Proof and Policy from Medical Research Evidence , 2001, Journal of health politics, policy and law.

[31]  M R Endsley,et al.  Level of automation effects on performance, situation awareness and workload in a dynamic control task. , 1999, Ergonomics.

[32]  Meral Binbasioglu,et al.  Knowledge-based management support: an application to the IS change agent role problem , 2003, Expert Syst. Appl..

[33]  R Haux,et al.  Towards Clinical Bioinformatics: Advancing Genomic Medicine with Informatics Methods and Tools , 2004, Methods of Information in Medicine.

[34]  Jatinder N. D. Gupta,et al.  A framework for building a learning organisation in the 21st century , 2005 .

[35]  Laura A. Petersen,et al.  Metcalfe's Law Predicts Reduced Power of Electronic Medical Record Software , 2003, AMIA.

[36]  Nilmini Wickramasinghe,et al.  Creating germane knowledge in dynamic environments , 2006 .

[37]  Matt Glasgow,et al.  Inaccessible information is useless information: addressing the knowledge gap. , 2002, The Journal of medical practice management : MPM.

[38]  Ida Sim,et al.  Evidence-based practice for mere mortals , 2002, Journal of General Internal Medicine.

[39]  Kirsti Malterud,et al.  For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group. the Nature of Clinical Knowledge the Art and Science of Clinical Knowledge: Evidence beyond Measures and Numbers Qualitative Research Series , 2022 .

[40]  James F. Courtney,et al.  Decision making and knowledge management in inquiring organizations: toward a new decision-making paradigm for DSS , 2001, Decis. Support Syst..

[41]  Elmer V. Bernstam,et al.  Instruments to assess the quality of health information on the World Wide Web: what can our patients actually use? , 2005, Int. J. Medical Informatics.

[42]  Attila Tarnok,et al.  Cytomics in predictive medicine , 2003, SPIE BiOS.

[43]  André Kushniruk,et al.  Analysis of Complex Decision-Making Processes in Health Care: Cognitive Approaches to Health Informatics , 2001, J. Biomed. Informatics.

[44]  Yan-Yan Yang,et al.  Preparing for the Third Millennium: the Views of Life Informatics , 1998, MedInfo.

[45]  Linda J Pike,et al.  Proteomics, genomics and the future of medical education. , 2004, Missouri medicine.

[46]  Jim Blair,et al.  Assessing the value of the internet in health improvement. , 2004, Nursing times.

[47]  Dragan Ilic,et al.  Searching the Internet for information on prostate cancer screening: an assessment of quality. , 2004, Urology.

[48]  Stephen B. Johnson A Framework for the Biomedical Informatics Curriculum , 2003, AMIA.

[49]  Dorothy E. Leidner,et al.  Studying Knowledge Management in Information Systems Resarch: Discourses and Theoretical Assumptions , 2002, MIS Q..

[50]  Michael D D McNeely,et al.  The use of expert systems for improving test use and enhancing the accuracy of diagnosis. , 2002, Clinics in laboratory medicine.

[51]  Rashbass The impact of information technology on histopathology , 2000, Histopathology.

[52]  L. Kohn,et al.  To Err Is Human : Building a Safer Health System , 2007 .

[53]  Hiroshi Ashida [What is bioinformatics?]. , 2002, Rinsho byori. The Japanese journal of clinical pathology.

[54]  David S. Celermajer Evidence‐based medicine: how good is the evidence? , 2001 .

[55]  Kun Chang Lee,et al.  KMPI: measuring knowledge management performance , 2005, Inf. Manag..

[56]  Alberto M Marchevsky,et al.  Evidence-based medicine, medical decision analysis, and pathology. , 2004, Human pathology.

[57]  Nilmini Wickramasinghe,et al.  Managing Knowledge Complexity , 2007 .

[58]  David S Alberts,et al.  Network Centric Warfare: Developing and Leveraging Information Superiority , 1999 .

[59]  A. Hodgkin,et al.  Measurement of current‐voltage relations in the membrane of the giant axon of Loligo , 1952, The Journal of physiology.

[60]  P B Fowler,et al.  Evidence-based everything. , 1997, Journal of evaluation in clinical practice.

[61]  D. M. Benjamin Reducing Medication Errors and Increasing Patient Safety: Case Studies in Clinical Pharmacology , 2003, Journal of clinical pharmacology.

[62]  M G Arellano,et al.  Issues in identification and linkage of patient records across an integrated delivery system. , 1998, Journal of healthcare information management : JHIM.

[63]  Attila Tárnok,et al.  Cytomics in predictive medicine , 2003, Cytometry. Part B, Clinical cytometry.

[64]  Barry Robson,et al.  Genomic messaging system and DNA mark-up language for information-based personalized medicine with clinical and proteome research applications. , 2004, Journal of proteome research.

[65]  Dorothy E. Leidner,et al.  Knowledge Management Systems: Issues, Challenges, and Benefits , 1999, Commun. Assoc. Inf. Syst..

[66]  Victor Maojo,et al.  Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care , 2004, J. Biomed. Informatics.

[67]  Jack Dowie Decision technologies and the independent professional: the future's challenge to learning and leadership , 2001 .

[68]  Boenning Da,et al.  The future of clinical research: the role of genomics, informatics, and evidence-based medicine. , 2001 .

[69]  R. Grant The Resource-Based Theory of Competitive Advantage: Implications for Strategy Formulation , 1991 .

[70]  M. Haugh,et al.  How should therapeutic information be transferred to users? , 2003, Fundamental & clinical pharmacology.

[71]  Michael J. Prietula,et al.  Factors Influencing Analysis of Complex Cognitive Tasks: A Framework and Example from Industrial Process Control , 2000, Hum. Factors.

[72]  H. Meyer,et al.  Bioinformatics in proteomics. , 2004, Current pharmaceutical biotechnology.

[73]  R. Hohlfeld,et al.  Neurologie 2000 Vom Molekül zum System , 1999, Der Nervenarzt.

[74]  E. Larson,et al.  Evidence-based medicine: is translating evidence into practice a solution to the cost-quality challenges facing medicine? , 1999, The Joint Commission journal on quality improvement.

[75]  Eric B Larson,et al.  Health Care System Chaos Should Spur Innovation: Summary of a Report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine , 2004, Annals of Internal Medicine.

[76]  Stephen J Chanock,et al.  Mining variations in genes of innate and phagocytic immunity: current status and future prospects , 2000, Current opinion in hematology.

[77]  George G Harrigan,et al.  Medicinal chemistry, metabolic profiling and drug target discovery: a role for metabolic profiling in reverse pharmacology and chemical genetics. , 2005, Mini reviews in medicinal chemistry.

[78]  Arthur K. Cebrowski,et al.  Network-Centric Warfare: Its Origin and Future , 1998 .

[79]  M Grinberg,et al.  Who needs evidence-based health care? , 1998, Bulletin of the Medical Library Association.

[80]  T Tjardes,et al.  New approaches to shock and trauma research: learning from multidisciplinary exchange. , 2004, The Journal of trauma.

[81]  M. Becich The Role of the Pathologist as Tissue Refiner and Data Miner: The Impact of Functional Genomics on the Modern Pathology Laboratory and the Critical Roles of Pathology Informatics and Bioinformatics , 2000, Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology.

[82]  Stjepan Gamulin,et al.  Impact of molecular medicine on pathophysiology, medical practice, and medical education. , 2003, Croatian medical journal.

[83]  W J Sibbald,et al.  From data to evidence: evaluative methods in evidence-based medicine. , 2001, Respiratory care.

[84]  Andrew Georgiou,et al.  Data information and knowledge: the health informatics model and its role in evidence-based medicine. , 2002, Journal of evaluation in clinical practice.

[85]  W D Graf,et al.  Can bioinformatics help trace the steps from gene mutation to disease? , 2000, Neurology.

[86]  W. Rosenberg,et al.  Evidence based medicine: an approach to clinical problem-solving , 1995, BMJ.

[87]  Kwong Yl Gene therapy---perspectives and promises. , 1997 .

[88]  D M D'Alessandro,et al.  Improving Usage of Pediatric Information on the Internet: The Virtual Children's Hospital , 1999, Pediatrics.

[89]  C. Parshuram,et al.  Fellowship training, workload, fatigue and physical stress: a prospective observational study , 2004, Canadian Medical Association Journal.

[90]  K Røhme,et al.  [When time counts--hospital physicians' use of time and work assignments]. , 2001, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.

[91]  A. Elstein,et al.  On the origins and development of evidence-based medicine and medical decision making , 2004, Inflammation Research.

[92]  G. Rubanyi,et al.  The future of human gene therapy. , 2001, Molecular aspects of medicine.

[93]  Mark A. Musen,et al.  The low availability of metadata elements for evaluating the quality of medical information on the World Wide Web , 1999, AMIA.

[94]  James T Rutka,et al.  Bioinformatics in Neurosurgery , 2003, Neurosurgery.

[95]  S S Anand,et al.  On prognostic models, artificial intelligence and censored observations. , 2001, Methods of information in medicine.

[96]  H. Hoyme,et al.  Pharmacogenomics: the future of drug therapy , 2002, Clinical genetics.

[97]  Elske Ammenwerth,et al.  Health care in the information society. A prognosis for the year 2013 , 2002, Int. J. Medical Informatics.

[98]  E R Weibel,et al.  Electron microscopic and morphometric study of rat lungs exposed to 97 per cent oxygen at 258 torr (27,000 feet). AMRL-TR-66-103. , 1966, AMRL-TR. Aerospace Medical Research Laboratories.

[99]  Daniel W Chan,et al.  Detection of prostate cancer using serum proteomics pattern in a histologically confirmed population. , 2004, The Journal of urology.

[100]  Elske Ammenwerth,et al.  Towards clinical bioinformatics: Advancing genomic medicine with informatics methods and tools - Findings from the IMIA Yearbook of Medical Informatics 2004 , 2004 .

[101]  Michael Thomas,et al.  Genome-wide screening for prognosis-predicting genes in early-stage non-small-cell lung cancer. , 2004, Lung cancer.

[102]  P. Candy,et al.  Preventing "information overdose": developing information-literate practitioners. , 2000, The Journal of continuing education in the health professions.

[103]  J. Claverie,et al.  From bioinformatics to computational biology. , 2000, Genome research.

[104]  W Hironaka,et al.  We must tackle population problems. , 1992, Integration.

[105]  M. Simmons,et al.  Combining Medical Informatics and Bioinformatics toward Tools for Personalized Medicine , 2003, Methods of Information in Medicine.

[106]  A. Lyngstadaas,et al.  STATUS AND POTENTIAL OF GENE THERAPY IN CLINICAL MEDICINE , 2002, International Journal of Technology Assessment in Health Care.

[107]  Ju Han Kim Bioinformatics and genomic medicine , 2002, Genetics in Medicine.

[108]  M R Lehto,et al.  A Proposed Conceptual Model of Human Behavior and its Implications for Design of Warnings , 1991, Perceptual and motor skills.

[109]  V Maojo,et al.  Bioinformatics: Towards New Directions for Public Health , 2004, Methods of Information in Medicine.

[110]  C. Argyris Reasoning, learning, and action : individual and organizational , 1982 .

[111]  Donald A. Schön,et al.  Organizational Learning: A Theory Of Action Perspective , 1978 .

[112]  N. Diemer,et al.  COMPLETE CEREBRAL ISCHAEMIA IN THE RAT: AN ULTRASTRUCTURAL AND STEREOLOGICAL ANALYSIS OF THE DISTAL STRATUM RADIATUM IN THE HIPPOCAMPAL CA‐1 REGION , 1982, Neuropathology and applied neurobiology.

[113]  Victor Maojo,et al.  Medical Informatics and Bioinformatics: European Efforts to Facilitate Synergy , 2001, J. Biomed. Informatics.

[114]  Ryozo Nagai,et al.  Development of a pioneering clinical support system utilizing information technology. , 2004, Japanese heart journal.

[115]  Thomas Reichherzer,et al.  Knowledge modeling and the creation of El-Tech: a performance support and training system for electronic technicians , 2003, Expert Syst. Appl..

[116]  H Kunov,et al.  An analysis of the paper-based health record: information content and its implications for electronic patient records. , 1995, Medinfo. MEDINFO.

[117]  Pamela C. Sieving,et al.  Factors Driving the Increase in Medical Information on the Web - One American Perspective , 1999, Journal of medical Internet research.

[118]  O. Hurko,et al.  The explosion of neurogenetics. , 1997, Current opinion in neurology.

[119]  C. McDonald,et al.  A randomized, controlled trial of clinical information shared from another institution. , 2002, Annals of emergency medicine.