X-ray elastography: A feasibility study

We propose a new elastography method based on x-ray imaging. After taking two x-ray tomographic images of the breast-mimicking phantom with applying different compressing pressure to it, we calculated displacement and strain maps from the two images using a non-rigid body image registration. The strain maps showed elasticity characteristics of the phantom medium. We expect that the proposed elastography method can be incorporated into breast tomosynthesis or breast CT systems to detect early stage breast cancers.

[1]  J. Ophir,et al.  Elastography: Elasticity Imaging Using Ultrasound with Application to Muscle and Breast in Vivo , 1993, Ultrasonic imaging.

[2]  Gyuseong Cho,et al.  Use of a flat-panel detector for microtomography: a feasibility study for small-animal imaging , 2005 .

[3]  Günter Lauritsch,et al.  Theoretical framework for filtered back projection in tomosynthesis , 1998, Medical Imaging.

[4]  James T. Dobbins,et al.  Optimization of matrix inverse tomosynthesis , 2001, SPIE Medical Imaging.

[5]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.

[6]  Richard L. Webber,et al.  Restoration of Digital Multiplane Tomosynthesis by a Constrained Iteration Method , 1984, IEEE Transactions on Medical Imaging.

[7]  J. F. Greenleaf,et al.  Magnetic resonance elastography: Non-invasive mapping of tissue elasticity , 2001, Medical Image Anal..

[8]  Min Hyoung Cho,et al.  A flat-panel detector based micro-CT system: performance evaluation for small-animal imaging. , 2003, Physics in medicine and biology.

[9]  James T Dobbins,et al.  Digital x-ray tomosynthesis: current state of the art and clinical potential. , 2003, Physics in medicine and biology.

[10]  Laurie L Fajardo,et al.  Breast tomosynthesis: present considerations and future applications. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[11]  Jonathan Ophir,et al.  Breast tumor classification using axial shear strain elastography: a feasibility study , 2008, Physics in medicine and biology.

[12]  Tor D Tosteson,et al.  Digital breast tomosynthesis: initial experience in 98 women with abnormal digital screening mammography. , 2007, AJR. American journal of roentgenology.

[13]  Daniel Rueckert,et al.  Nonrigid registration using free-form deformations: application to breast MR images , 1999, IEEE Transactions on Medical Imaging.