120 PATHOLOGIC GAMBLING AND IMPULSE CONTROL DISORDERS

Impaired regulation of impulse is a central feature in several psychiatric disorders and behaviors, including drug use disorders, cluster B personality disorders such as borderline personality disorder, bipolar disorders, and suicide attempts. The DSM-IV’s ‘‘impulse control disorders (ICDs) not specified elsewhere’’ (1) have historically received less attention than other psychiatric conditions. This heterogeneous group of illnesses includes intermittent explosive disorder, kleptomania, pyromania, pathologic gambling (PG), trichotillomania, and ICDs not otherwise specified. We review the neurobiology and treatment of one of these ICDs, PG, and describe the nature and treatments of several other potentially related conditions that have recently received increased attention: (a) compulsive buying (CB); (b) compulsive sexual behavior (CSB); and (c) compulsive computer use (CCU). These disorders, linked by a failure to resist urges to engage in ultimately self-destructive behaviors, appear to be relatively common, frequently go unrecognized for considerable periods, and may constitute greater threats to personal health than is often appreciated.

[1]  E. Hollander,et al.  Obsessive-compulsive spectrum disorders , 2003, Dialogues in clinical neuroscience.

[2]  D. Ciraulo Neuropsychopharmacology: The Fifth Generation of Progress , 2003 .

[3]  Carlo Contoreggi,et al.  Drug abusers show impaired performance in a laboratory test of decision making , 2000, Neuropsychologia.

[4]  E. Hollander,et al.  A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling , 2000, Biological Psychiatry.

[5]  A. Damasio,et al.  Emotion, decision making and the orbitofrontal cortex. , 2000, Cerebral cortex.

[6]  M. Ernst,et al.  Orbitofrontal cortex and human drug abuse: functional imaging. , 2000, Cerebral cortex.

[7]  M. Kafka Psychopharmacologic Treatments for Nonparaphilic Compulsive Sexual Behaviors , 2000, CNS Spectrums.

[8]  Al Cooper,et al.  Cybersex users, abusers, and compulsives: New findings and implications , 2000 .

[9]  D. Black The Epidemiology and Phenomenology of Compulsive Sexual Behavior , 2000, CNS Spectrums.

[10]  D. Black,et al.  Clinical features, psychiatric comorbidity, and health-related quality of life in persons reporting compulsive computer use behavior. , 1999, The Journal of clinical psychiatry.

[11]  C. Nordin,et al.  Altered CSF 5-HIAA Disposition in Pathologic Male Gamblers , 1999, CNS Spectrums.

[12]  M. Dı́az-Marsá,et al.  Low Platelet Monoamine Oxidase Activity in Sensation-Seeking Bullfighters , 1999, CNS Spectrums.

[13]  Jonathan D. Cohen,et al.  Conflict monitoring versus selection-for-action in anterior cingulate cortex , 1999, Nature.

[14]  J. Hennen,et al.  Estrogen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia: results from a short-term, randomized, double-blind trial. , 1999, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[15]  G Saucier,et al.  Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. , 1999, American journal of medical genetics.

[16]  N. Petry,et al.  Prevalence, assessment, and treatment of pathological gambling: a review. , 1999, Psychiatric services.

[17]  Gregory P. Lee,et al.  Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making , 1999, The Journal of Neuroscience.

[18]  C. Halldin,et al.  Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. , 1999, The American journal of psychiatry.

[19]  M. Pratarelli,et al.  The bits and bytes of computer/internet addiction: A factor analytic approach , 1999, Behavior research methods, instruments, & computers : a journal of the Psychonomic Society, Inc.

[20]  J. Fernández-Piqueras,et al.  Genetic contribution to pathological gambling: possible association between a functional DNA polymorphism at the serotonin transporter gene (5-HTT) and affected men. , 1999, Pharmacogenetics.

[21]  K. Terasawa,et al.  Physiological changes in Pachinko players; beta-endorphin, catecholamines, immune system substances and heart rate. , 1999, Applied human science : journal of physiological anthropology.

[22]  B. Martis,et al.  Are sex offenders treatable? A research overview. , 1999, Psychiatric services.

[23]  N. Owens,et al.  Pharmacologic Treatment of Hypersexuality and Paraphilias in Nursing Home Residents , 1999, Journal of the American Geriatrics Society.

[24]  A. Blaszczynski Pathological Gambling and Obsessive-Compulsive Spectrum Disorders , 1999, Psychological reports.

[25]  E. Hollander,et al.  Short-term single-blind fluvoxamine treatment of pathological gambling. , 1998, The American journal of psychiatry.

[26]  C. Nordin,et al.  Tapping time at lumbar puncture is longer in pathological male gamblers than in healthy male controls. , 1998, Journal of psychiatric research.

[27]  M. Tsuang,et al.  Familial influences on gambling behavior: an analysis of 3359 twin pairs. , 1998, Addiction.

[28]  E. Hollander Treatment of obsessive-compulsive spectrum disorders with SSRIs , 1998, British Journal of Psychiatry.

[29]  W. Compton,et al.  Taking chances: problem gamblers and mental health disorders--results from the St. Louis Epidemiologic Catchment Area Study. , 1998, American journal of public health.

[30]  D. Black,et al.  Family history and psychiatric comorbidity in persons with compulsive buying: preliminary findings. , 1998, The American journal of psychiatry.

[31]  D. Comings The Molecular Genetics of Pathological Gambling , 1998, CNS Spectrums.

[32]  E. Hollander,et al.  Serotonergic and Noradrenergic Function in Pathological Gambling , 1998, CNS Spectrums.

[33]  G. A. Harrison,et al.  Variation in epinephrine and cortisol excretion rates associated with behavior in an Australian Aboriginal community. , 1998, American journal of physical anthropology.

[34]  D. Brooks,et al.  Evidence for striatal dopamine release during a video game , 1998, Nature.

[35]  Suck-Won Kim,et al.  Opioid antagonists in the treatment of impulse-control disorders. , 1998, The Journal of clinical psychiatry.

[36]  E. Witztum,et al.  Treatment of men with paraphilia with a long-acting analogue of gonadotropin-releasing hormone. , 1998, The New England journal of medicine.

[37]  N. el-Guebaly,et al.  Naltrexone in the treatment of pathological gambling and alcohol dependence. , 1998, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[38]  N. el-Guebaly,et al.  Psychiatric Comorbidity in Pathological Gambling: A Critical Review , 1998, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[39]  H. Damasio,et al.  Dissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex , 1998, The Journal of Neuroscience.

[40]  G. Nestadt,et al.  Association of obsessive‐compulsive disorder and pathological gambling with Huntington's disease in an Italian pedigree: possible association with Huntington's disease mutation , 1998, Acta psychiatrica Scandinavica.

[41]  Dan J Stein,et al.  Psychosocial Function and Economic Costs of Obsessive-Compulsive Disorder , 1997, CNS Spectrums.

[42]  L. Siever,et al.  D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. , 1997, American journal of human genetics.

[43]  R. Ladouceur,et al.  Cognitive and behavioral treatment of pathological gambling: a controlled study. , 1997, Journal of consulting and clinical psychology.

[44]  J. Fernández-Piqueras,et al.  Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. , 1997, Pharmacogenetics.

[45]  J. Bradford,et al.  Treatment of the paraphilic disorders: A review of the role of the selective serotonin reuptake inhibitors , 1997 .

[46]  L. Lothstein,et al.  Risk management and treatment of sexual disinhibition in geriatric patients. , 1997, Connecticut medicine.

[47]  Bob Davis,et al.  Gambling, alcohol & other drugs : prevalence & implications of dual problem clients , 1997 .

[48]  S. Hyman,et al.  Acute Effects of Cocaine on Human Brain Activity and Emotion , 1997, Neuron.

[49]  M. Nöthen,et al.  Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. , 1997, The American journal of psychiatry.

[50]  S. J. Gatley,et al.  Relationship between subjective effects of cocaine and dopamine transporter occupancy , 1997, Nature.

[51]  D. Black,et al.  Fluvoxamine in the treatment of compulsive buying. , 1997, The Journal of clinical psychiatry.

[52]  J. Adès,et al.  Study of compulsive buying in depressed patients. , 1997, The Journal of clinical psychiatry.

[53]  P. Södersten,et al.  Altered dopamine function in pathological gambling , 1997, Psychological Medicine.

[54]  A. Damasio,et al.  Deciding Advantageously Before Knowing the Advantageous Strategy , 1997, Science.

[55]  D. Black,et al.  Compulsive computer use. , 1997, The American journal of psychiatry.

[56]  K. Young,et al.  Psychology of Computer Use: XL. Addictive Use of the Internet: A Case That Breaks the Stereotype , 1996, Psychological reports.

[57]  S. Curry,et al.  A comparison of treatment of paraphilias with three serotonin reuptake inhibitors: a retrospective study. , 1996, The Bulletin of the American Academy of Psychiatry and the Law.

[58]  J. Adès,et al.  Phenomenology and psychopathology of uncontrolled buying. , 1996, The American journal of psychiatry.

[59]  R. Murray,et al.  A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. , 1996, Molecular psychiatry.

[60]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[61]  A. Cosby,et al.  Legalization of crimes against the moral order: Results from the 1995 United States survey of gaming and gambling , 1996 .

[62]  S. Faraone,et al.  Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. , 1996, American journal of medical genetics.

[63]  C. Nordin,et al.  Lower CSF Taurine Levels in Male Pathological Gamblers than in Healthy Controls , 1996 .

[64]  E. Hollander,et al.  Is There a Distinct OCD Spectrum? , 1996, CNS Spectrums.

[65]  P Riederer,et al.  Allelic Variation of Human Serotonin Transporter Gene Expression , 1996, Journal of neurochemistry.

[66]  D. Comings,et al.  A study of the dopamine D2 receptor gene in pathological gambling. , 1996, Pharmacogenetics.

[67]  R. Hoffman,et al.  Naltrexone as a treatment for repetitive self-injurious behaviour:an open-label trial. , 1996, The Journal of clinical psychiatry.

[68]  J. Schneider,et al.  Couple recovery from sexual addiction / co addiction: Results of a survey of 88 marriages , 1996 .

[69]  E. Nestler,et al.  Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists , 1996, Science.

[70]  John G. Cull,et al.  REWARD DEFICIENCY SYNDROME , 1996 .

[71]  R. Smart,et al.  Alcohol, Drugs and Gambling in the Ontario Adult Population, 1994 , 1996, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[72]  H. Lesieur,et al.  Pathological gambling among methadone patients. , 1995, Drug and alcohol dependence.

[73]  Thomas J. H. Chen,et al.  Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. , 1995, Pharmacogenetics.

[74]  J. Volpicelli,et al.  Effect of naltrexone on alcohol "high" in alcoholics. , 1995, The American journal of psychiatry.

[75]  R. Ladouceur,et al.  Treatment of pathological gamblers: an experimental study. , 1994, Journal of behavior therapy and experimental psychiatry.

[76]  E. Hollander,et al.  Low platelet monoamine oxidase activity in pathological gambling , 1994, Acta psychiatrica Scandinavica.

[77]  M. Kafka Sertraline pharmacotherapy for paraphilias and paraphilia-related disorders: an open trial. , 1994, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[78]  H. Hinterhuber,et al.  Treatment of Pathological Gambling with Carbamazepine , 1994, Pharmacopsychiatry.

[79]  S. Schlosser,et al.  Compulsive buying. Demography, phenomenology, and comorbidity in 46 subjects. , 1994, General hospital psychiatry.

[80]  A. Damasio,et al.  Insensitivity to future consequences following damage to human prefrontal cortex , 1994, Cognition.

[81]  R. Goldstein,et al.  Compulsive behaviors and obsessive-compulsive disorder (OCD): lack of a relationship between OCD, eating disorders, and gambling. , 1994, Comprehensive psychiatry.

[82]  Dan J Stein,et al.  Serotonergic sensitivity in borderline personality disorder: preliminary findings. , 1994, The American journal of psychiatry.

[83]  A. Pawlak,et al.  Double-blind placebo crossover study of cyproterone acetate in the treatment of the paraphilias , 1993, Archives of sexual behavior.

[84]  C. Nordin,et al.  Tapping-time influences concentrations of 5-HIAA in the CSF , 1993 .

[85]  D. Schubert,et al.  Low-dose oral medroxyprogesterone acetate in the management of the paraphilias. , 1993, The Journal of clinical psychiatry.

[86]  L. Rugle,et al.  Neuropsychological Assessment of Attention Problems in Pathological Gamblers , 1993, The Journal of nervous and mental disease.

[87]  Z. Cernovsky,et al.  A Double-Blind Placebo Controlled Trial of Medroxyprogesterone Acetate and Cyproterone Acetate with Seven Pedophiles , 1992, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[88]  J. Rapoport,et al.  Paraphilias: A double-blind crossover comparison of clomipramine versus desipramine , 1992, Archives of sexual behavior.

[89]  S. Rasmussen,et al.  The epidemiology and clinical features of obsessive compulsive disorder. , 1992, The Psychiatric clinics of North America.

[90]  Ronald J. Faber,et al.  A Clinical Screener for Compulsive Buying , 1992 .

[91]  B. Rounsaville,et al.  Naltrexone and coping skills therapy for alcohol dependence. A controlled study. , 1992, Archives of general psychiatry.

[92]  R. Prentky,et al.  Fluoxetine treatment of nonparaphilic sexual addictions and paraphilias in men. , 1992, The Journal of clinical psychiatry.

[93]  R. Dickey The Management of a Case of Treatment-Resistant Paraphilia with a Long-Acting LHRH Agonist* , 1992, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[94]  P. Seeman,et al.  Multiple dopamine D4 receptor variants in the human population , 1992, Nature.

[95]  E. Coleman,et al.  Is Your Patient Suffering from Compulsive Sexual Behavior , 1992 .

[96]  D. Stein,et al.  Treatment of pathological gambling with clomipramine. , 1992, The American journal of psychiatry.

[97]  B. Rounsaville,et al.  Cocaine Abuse and Pathological Gambling , 1992 .

[98]  P. Keck,et al.  The DSM-III-R impulse control disorders not elsewhere classified: clinical characteristics and relationship to other psychiatric disorders. , 1992, The American journal of psychiatry.

[99]  E. Emory,et al.  Depo-provera treatment for sex-offending behavior: An evaluation of outcome Walter J. Meyer, III, Collier Cole, Evangeline Emory University of Texas Medical Branch, Galveston, TX 77555-0429 , 1992, Biological Psychiatry.

[100]  J. Saiz-ruiz,et al.  Serotonin and gambling dependence , 1991 .

[101]  A. Blaszczynski,et al.  Comparison of Imaginal Desensitisation with other Behavioural Treatments of Pathological Gambling a Two- to Nine-Year Follow-up , 1991, British Journal of Psychiatry.

[102]  P. Keck,et al.  Treatment of Compulsive Shopping with Antidepressants: a Report of Three Cases , 1991 .

[103]  D. Murphy,et al.  Ethanollike properties of the serotonergic partial agonist m-chlorophenylpiperazine in chronic alcoholic patients. , 1991, Archives of general psychiatry.

[104]  L. J. Friedman,et al.  Three cases of paraphilias responsive to fluoxetine treatment. , 1991, The Journal of clinical psychiatry.

[105]  Patrick J. Carnes,et al.  Don't Call It Love: Recovery From Sexual Addiction , 1991 .

[106]  M. Kafka Successful antidepressant treatment of nonparaphilic sexual addictions and paraphilias in men. , 1991, The Journal of clinical psychiatry.

[107]  I Marks,et al.  Behavioural (non-chemical) addictions. , 1990, British journal of addiction.

[108]  W. Berrettini,et al.  CSF neuropeptide Y in alcoholics and normal controls , 1990, Psychiatry Research.

[109]  Jeffrey K. Yao,et al.  Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse , 1990, Biological Psychiatry.

[110]  T. Kiersch Treatment of sex offenders with Depo-Provera. , 1990, The Bulletin of the American Academy of Psychiatry and the Law.

[111]  W. Hole,et al.  A case report of naltrexone treatment of self-injury and social withdrawal in autism , 1990, Journal of autism and developmental disorders.

[112]  B. Adinoff,et al.  CSF galanin in alcoholics, pathological gamblers, and normal controls: A negative report , 1990, Biological Psychiatry.

[113]  L. Oreland,et al.  Blood platelet monoamine oxidase activity, serotonin uptake and release rates in anorexia and bulimia patients and in healthy controls , 1990, Acta psychiatrica Scandinavica.

[114]  D. Rubinow,et al.  CSF GABA and neuropeptides in pathological gamblers and normal controls , 1989, Psychiatry Research.

[115]  M Linnoila,et al.  Extraversion in pathological gamblers. Correlates with indexes of noradrenergic function. , 1989, Archives of general psychiatry.

[116]  L. Siever,et al.  Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. , 1989, Archives of general psychiatry.

[117]  W. Hole,et al.  Effects of naloxone and naltrexone on self-injury: a double-blind, placebo-controlled analysis. , 1989, American journal of mental retardation : AJMR.

[118]  D. Pickar,et al.  Diazepam binding inhibitor and corticotropin releasing hormone in cerebrospinal fluid , 1989, Biological Psychiatry.

[119]  S. Peroutka,et al.  1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain , 1989, Biological Psychiatry.

[120]  R. McCormick,et al.  Plasma Cortisol and Depression in Pathological Gamblers , 1988, British Journal of Psychiatry.

[121]  J. Fedoroff,et al.  Buspirone hydrochloride in the treatment of transvestic fetishism. , 1988, The Journal of clinical psychiatry.

[122]  G. Kennett,et al.  Evidence that mCPP may have behavioural effects mediated by central 5‐HT1C receptors , 1988, British journal of pharmacology.

[123]  M. Linnoila,et al.  Pathological gambling. A psychobiological study. , 1988, Archives of general psychiatry.

[124]  R. M. Stewart,et al.  An Outcome Study of Gamblers Anonymous , 1988, British Journal of Psychiatry.

[125]  E. Coleman Sexual Compulsivity:: Definition, Etiology, and Treatment Considerations , 1987 .

[126]  D. Kagan Addictive personality factors. , 1987, The Journal of psychology.

[127]  L. Knorring,et al.  Personality traits and platelet MAO activity in alcohol and drug abusing teenage boys , 1987, Acta psychiatrica Scandinavica.

[128]  Trevor R. Norman,et al.  Low platelet monoamine oxidase and sensation seeking in males: an established relationship? , 1987, Acta psychiatrica Scandinavica.

[129]  H. Pope,et al.  Pathological gambling and major affective disorder: preliminary findings. , 1986, The Journal of clinical psychiatry.

[130]  J. M. Ree,et al.  Effects of morphine and naloxone on thresholds of ventral tegmental electrical self-stimulation , 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

[131]  R. McCormick,et al.  Affective disorders among pathological gamblers seeking treatment. , 1984, The American journal of psychiatry.

[132]  M Linnoila,et al.  Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. , 1983, Life sciences.

[133]  A. Blaszczynski,et al.  Controlled Comparison of Aversive Therapy and Imaginal Desensitization in Compulsive Gambling , 1983, British Journal of Psychiatry.

[134]  X. Breakefield,et al.  Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[135]  M. Åsberg,et al.  Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls , 1982, Psychiatry Research.

[136]  R. Snaith,et al.  Five Exhibitionists and a Method of Treatment , 1981, British Journal of Psychiatry.

[137]  M. Åsberg,et al.  Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls , 1981, Psychiatry Research.

[138]  L. Knorring,et al.  Platelet monoamine oxidase activity in sensation seekers , 1980, Psychiatry Research.

[139]  A. Phillips,et al.  Reinforcing effects of morphine microinjection into the ventral tegmental area , 1980, Pharmacology Biochemistry and Behavior.

[140]  D. Murphy,et al.  Suicide attempts, platelet monoamine oxidase and the average evoked response , 1977, Acta psychiatrica Scandinavica.

[141]  M. Åsberg,et al.  5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? , 1976, Archives of general psychiatry.

[142]  N. Ward Successful lithium treatment of transvestism associated with manic-depression. , 1975, The Journal of nervous and mental disease.

[143]  E. Bleuler,et al.  Textbook of Psychiatry , 1907, Buffalo Medical Journal.

[144]  K. Winters,et al.  A Twin Study of Adult Gambling Behavior , 2004, Journal of Gambling Studies.

[145]  H O Fekjaer,et al.  [Pathological gambling]. , 2001, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.

[146]  M. Reivich,et al.  Limbic activation during cue-induced cocaine craving. , 1999, The American journal of psychiatry.

[147]  J S Fowler,et al.  Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. , 1999, The American journal of psychiatry.

[148]  P F Renshaw,et al.  Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. , 1998, The American journal of psychiatry.

[149]  P. Sullivan,et al.  No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples. , 1998, The American journal of psychiatry.

[150]  M. Griffiths Internet addiction: Does it really exist? , 1998 .

[151]  E. Ochoa Mangado [Naltrexone in the treatment of alcohol dependence]. , 1998, Actas luso-espanolas de neurologia, psiquiatria y ciencias afines.

[152]  J. Gackenbach Psychology and the Internet : intrapersonal, interpersonal, and transpersonal implications , 1998 .

[153]  D. Comings,et al.  Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors , 1997, Molecular Psychiatry.

[154]  G. Koob,et al.  The neurobiology of drug addiction. , 1997, The Journal of neuropsychiatry and clinical neurosciences.

[155]  C. Blanco,et al.  Pathological gambling and platelet MAO activity: a psychobiological study. , 1996, The American journal of psychiatry.

[156]  R. Ebstein,et al.  Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking , 1996, Nature Genetics.

[157]  D. Murphy,et al.  Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking , 1996, Nature Genetics.

[158]  J. Adès,et al.  Compulsive buying and depression. , 1995, The Journal of clinical psychiatry.

[159]  E. Hollander,et al.  Body dysmorphic disorder, pathological gambling, and sexual compulsions. , 1995, The Journal of clinical psychiatry.

[160]  H. Lesieur,et al.  Gambling among methadone patients. , 1995, The International journal of the addictions.

[161]  E. Nestler,et al.  Molecular mechanisms of drug reinforcement and addiction. , 1995, Annual review of neuroscience.

[162]  J M Smith,et al.  Compulsive buying: a report of 20 cases. , 1994, The Journal of clinical psychiatry.

[163]  Ronald J. Faber,et al.  Compulsive buying: descriptive characteristics and psychiatric comorbidity. , 1994, The Journal of clinical psychiatry.

[164]  J. Fedoroff Serotonergic drug treatment of deviant sexual interests , 1993 .

[165]  E. Hollander Obsessive-compulsive-related disorders , 1993 .

[166]  G. Koob Drugs of abuse: anatomy, pharmacology and function of reward pathways. , 1992, Trends in pharmacological sciences.

[167]  W. Goodman,et al.  Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. , 1989, Archives of general psychiatry.

[168]  E. Coleman,et al.  Use of lithium carbonate in the treatment of autoerotic asphyxia. , 1989, American journal of psychotherapy.

[169]  D. Hoyer Functional correlates of serotonin 5-HT1 recognition sites. , 1988, Journal of receptor research.

[170]  S B Blume,et al.  Alcoholism, drug abuse, and gambling. , 1986, Alcoholism, clinical and experimental research.

[171]  J. Moskowitz Lithium and lady luck; use of lithium carbonate in compulsive gambling. , 1980, New York state journal of medicine.

[172]  M. Zuckerman Sensation Seeking : Beyond the Optimal Level of Arousal , 1979 .

[173]  J. Švestka,et al.  Pharmacological treatment of deviant sexual behaviour. , 1978, Activitas nervosa superior.

[174]  S. Snyder,et al.  Frontiers in catecholamine research : proceedings , 1973 .

[175]  P. Haberman Drinking and Other Self-Indulgences: Complements or Counter-Attractions? , 1969 .

[176]  Eyres Ae Transvestitism: (employment of somatic therapy with subsequent improvement). , 1960 .