The olfactory bulb: coding and processing of odor molecule information.

Olfactory sensory neurons detect a large variety of odor molecules and send information through their axons to the olfactory bulb, the first site for the processing of olfactory information in the brain. The axonal connection is precisely organized so that signals from 1000 different types of odorant receptors are sorted out in 1800 glomeruli in the mouse olfactory bulb. Individual glomerular modules presumably represent a single type of receptor and are thus tuned to specific molecular features of odorants. Local neuronal circuits in the bulb mediate lateral inhibition among glomerular modules to sharpen the tuning specificity of output neurons. They also mediate synchronized oscillatory discharges among specific combinations of output neurons and may contribute to the integration of signals from distinct odorant receptors in the olfactory cortex.

[1]  E. Adrian,et al.  The electrical activity of the mammalian olfactory bulb. , 1950, Electroencephalography and clinical neurophysiology.

[2]  W. E. Clark,et al.  THE PROJECTION OF THE OLFACTORY EPITHELIUM ON THE OLFACTORY BULB IN THE RABBIT , 1951, Journal of neurology, neurosurgery, and psychiatry.

[3]  G. Wasserburg,et al.  Olfactory Discrimination in the Rabbit Olfactory Glomerulus , 1966, Science.

[4]  G. Shepherd,et al.  Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. , 1968, Journal of neurophysiology.

[5]  R. Nicoll,et al.  Inhibitory mechanisms in the rabbit olfactory bulb: dendrodendritic mechanisms. , 1969, Brain research.

[6]  T. Powell,et al.  The neuropil of the glomeruli of the olfactory bulb. , 1971, Journal of cell science.

[7]  Y. Oomura,et al.  Food intake and chemical senses , 1977 .

[8]  G. Shepherd,et al.  Functional organization of rat olfactory bulb analysed by the 2‐deoxyglucose method , 1979, The Journal of comparative neurology.

[9]  G. Shepherd.  The Synaptic Organization of the Brain , 1979 .

[10]  L. Astic,et al.  Spatial distribution of [14C]2-deoxyglucose uptake in the olfactory bulbs of rats stimulated with two different odours , 1980, Brain Research.

[11]  J S Kauer,et al.  Mapping of odor-related neuronal activity in the olfactory bulb by high-resolution 2-deoxyglucose autoradiography. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[12]  A. Holley,et al.  Receptor cell responses to odorants: Similarities and differences among odorants , 1984, Brain Research.

[13]  K. Obata,et al.  Immunohistochemical study of subclasses of olfactory nerve fibers and their projections to the olfactory bulb in the rabbit , 1985, The Journal of comparative neurology.

[14]  K. Obata,et al.  Subclasses of olfactory receptor cells and their segregated central projections demonstrated by a monoclonal antibody , 1985, Brain Research.

[15]  L. Astic,et al.  Analysis of the topographical organization of olfactory epithelium projections in the rat , 1986, Brain Research Bulletin.

[16]  D. Gottlieb,et al.  The primary olfactory projection has two chemically distinct zones , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  M. Leon.  Plasticity of olfactory output circuits related to early olfactory learning , 1987, Trends in Neurosciences.

[18]  D. Wilson,et al.  Evidence of lateral synaptic interactions in olfactory bulb output cell responses to odors , 1987, Brain Research.

[19]  G M Shepherd,et al.  A Molecular Vocabulary for Olfaction a , 1987, Annals of the New York Academy of Sciences.

[20]  N Buonviso,et al.  Response similarity to odors in olfactory bulb output cells presumed to be connected to the same glomerulus: electrophysiological study using simultaneous single-unit recordings. , 1990, Journal of neurophysiology.

[21]  J. Crandall,et al.  Subsets of olfactory and vomeronasal sensory epithelial cells and axons revealed by monoclonal antibodies to carbohydrate antigens , 1991, Brain Research.

[22]  R. Axel,et al.  A novel multigene family may encode odorant receptors: A molecular basis for odor recognition , 1991, Cell.

[23]  K. Imamura,et al.  Differential specificities of single mitral cells in rabbit olfactory bulb for a homologous series of fatty acid odor molecules. , 1992, Journal of neurophysiology.

[24]  R. Reed,et al.  Signaling pathways in odorant detection , 1992, Neuron.

[25]  H. Breer,et al.  Expression of odorant receptors in spatially restricted subsets of chemosensory neurones. , 1992, Neuroreport.

[26]  N. Onoda.  Odor-induced fos-like immunoreactivity in the rat olfactory bulb , 1992, Neuroscience Letters.

[27]  S. Heinemann,et al.  Spatial pattern of receptor expression in the olfactory epithelium. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[28]  AC Tose.  Cell , 1993, Cell.

[29]  F Jourdan,et al.  C-fos expression and 2-deoxyglucose uptake in the olfactory bulb of odour-stimulated awake rats. , 1993, Neuroreport.

[30]  C. Gall,et al.  Odor-induced increases in c-fos mRNA expression reveal an anatomical "unit" for odor processing in olfactory bulb. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Richard Axel,et al.  Coding of olfactory information: Topography of odorant receptor expression in the catfish olfactory epithelium , 1993, Cell.

[32]  Linda B. Buck,et al.  A zonal organization of odorant receptor gene expression in the olfactory epithelium , 1993, Cell.

[33]  Richard Axel,et al.  Topographic organization of sensory projections to the olfactory bulb , 1994, Cell.

[34]  G M Shepherd,et al.  Emerging principles of molecular signal processing by mitral/tufted cells in the olfactory bulb. , 1994, Seminars in cell biology.

[35]  M. Tonoike,et al.  Tuning specificities to aliphatic odorants in mouse olfactory receptor neurons and their local distribution. , 1994, Journal of neurophysiology.

[36]  S. Nakanishi,et al.  Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[37]  C. Gall,et al.  Functional mapping of odor-activated neurons in the olfactory bulb. , 1995, Chemical senses.

[38]  Yoshihiro Yoshihara,et al.  Molecular recognition and olfactory processing in the mammalian olfactory system , 1995, Progress in Neurobiology.

[39]  K. Ressler,et al.  Spatial patterning and information coding in the olfactory system. , 1995, Current opinion in genetics & development.

[40]  H. Kaba,et al.  Synaptic Mechanisms of Olfactory Recognition Memory , 1995, Reviews in the neurosciences.

[41]  W Singer,et al.  Visual feature integration and the temporal correlation hypothesis. , 1995, Annual review of neuroscience.

[42]  G. Laurent.  Dynamical representation of odors by oscillating and evolving neural assemblies , 1996, Trends in Neurosciences.

[43]  L. Buck,et al.  Information coding in the vertebrate olfactory system. , 1996, Annual review of neuroscience.

[44]  M Ennis,et al.  Functional organization of olfactory system. , 1996, Journal of neurobiology.

[45]  Richard Axel,et al.  Visualizing an Olfactory Sensory Map , 1996, Cell.

[46]  M. Alenius,et al.  Identification of a Novel Neural Cell Adhesion Molecule-related Gene with a Potential Role in Selective Axonal Projection* , 1997, The Journal of Biological Chemistry.

[47]  P. Brennan,et al.  NEURAL MECHANISMS OF MAMMALIAN OLFACTORY LEARNING , 1997, Progress in Neurobiology.

[48]  J. Isaacson,et al.  Olfactory Reciprocal Synapses: Dendritic Signaling in the CNS , 1998, Neuron.

[49]  J. Kauer,et al.  Odorant Response Properties of Convergent Olfactory Receptor Neurons , 1998, The Journal of Neuroscience.

[50]  R G Shulman,et al.  Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[51]  R Gervais,et al.  A re-estimation of the number of glomeruli and mitral cells in the olfactory bulb of rabbit , 1998, Brain Research.

[52]  Michael Leon,et al.  Spatial coding of odorant features in the glomerular layer of the rat olfactory bulb , 1998 .

[53]  R. Axel,et al.  A Map of Pheromone Receptor Activation in the Mammalian Brain , 1999, Cell.

[54]  N. Uchida,et al.  Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb. , 1999, Journal of neurophysiology.

[55]  P. Mombaerts.  Seven-transmembrane proteins as odorant and chemosensory receptors. , 1999, Science.

[56]  L. C. Katz,et al.  Optical Imaging of Odorant Representations in the Mammalian Olfactory Bulb , 1999, Neuron.

[57]  H. Okano,et al.  A Genetic Approach to Visualization of Multisynaptic Neural Pathways Using Plant Lectin Transgene , 1999, Neuron.

[58]  P. Duchamp-Viret,et al.  Odor response properties of rat olfactory receptor neurons. , 1999, Science.

[59]  J. Ashby.  References and Notes , 1999 .

[60]  L. Buck,et al.  A genetic approach to trace neural circuits. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[61]  D. Wilkin,et al.  Neuron , 2001, Brain Research.