Inter-connection between mitochondria and HIFs

•  Introduction •  Oxidative phosphorylation •  Hypoxic activation of HIFs •  Mitochondria regulate HIFs ‐  Mitochondrial ROS regulate HIFs ‐  Mitochondrial respiration regulate HIFs ‐  TCA cycle intermediates regulate HIFs •  Hypoxia decreases cellular ATP utilization to diminish mitochondrial respiration •  HIF‐1 regulates mitochondrial respiration •  HIF‐2 regulates mitochondrial oxidative stress •  Conclusion

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