Anti-androgenic activity of 7,8,9,10-tetra-hydro-7-oxo-benzo (c) phenanthridine (A11-IV) on immature, castrated, male rats.

One of the aza-analogues, 7,8,9,10-tetrahydro-7-oxo-benzo (c) phenanthridine exhibited an anti-androgenic activity on immature, castrated, male rats. The compound had an interesting anti-androgenic activity as the effect of testosterone-induced gain in weight of the ventral prostate was significantly inhibited by the compound. This compound did not, however, inhibit the androgen-induced weight increase of the seminal vesicle.