Hematopoiesis and the Kidney
暂无分享,去创建一个
[1] J. Epstein,et al. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. , 2010, Blood.
[2] W. Kaelin,et al. Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss , 2010, Science.
[3] R. Wenger,et al. Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells. , 2010, American journal of physiology. Renal physiology.
[4] E. Huizinga,et al. Erythrocytosis associated with a novel missense mutation in the HIF2A gene , 2010, Haematologica.
[5] N. Kosaka,et al. Structural and biological properties of erythropoietin in Xenopus laevis. , 2010, Experimental hematology.
[6] S. Bachmann,et al. Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. , 2010, Kidney international.
[7] B. Buchholz,et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model , 2009, Proceedings of the National Academy of Sciences.
[8] D. Kleinfeld,et al. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. , 2009, The Journal of clinical investigation.
[9] W. Kaelin,et al. A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo , 2009, Molecular and Cellular Biology.
[10] B. Buchholz,et al. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. , 2009, The American journal of pathology.
[11] M. Buset,et al. Radioimmunoassay of erythropoietin in chronic uraemia or anephric patients. , 2009, Scandinavian journal of haematology.
[12] Kun-Liang Guan,et al. Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α , 2009, Science.
[13] S. Master,et al. Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline* , 2009, Journal of Biological Chemistry.
[14] D. Katschinski. In vivo functions of the prolyl‐4‐hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissues , 2009, Acta physiologica.
[15] R. Paus,et al. Erythropoietin and the skin: a role for epidermal oxygen sensing? , 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.
[16] P. Carmeliet,et al. Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease , 2009, Nature Reviews Drug Discovery.
[17] F. Galateau-Sallé,et al. PHD2 mutation and congenital erythrocytosis with paraganglioma. , 2008, The New England journal of medicine.
[18] C. Noguchi,et al. Survival and proliferative roles of erythropoietin beyond the erythroid lineage , 2008, Expert Reviews in Molecular Medicine.
[19] A. Cariou,et al. Extra-hematopoietic effects of erythropoietin. , 2008, Cardiovascular & hematological disorders drug targets.
[20] C. Bartram,et al. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF 2 , 2008 .
[21] Cheng-Ying Chu,et al. Erythropoietins from teleosts , 2008, Cellular and Molecular Life Sciences.
[22] T. Cenci,et al. A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis , 2008, Haematologica.
[23] A. Green,et al. Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. , 2008, Blood.
[24] Kai-Uwe Eckardt,et al. Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response , 2008, Cell.
[25] J. Pouysségur,et al. PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis , 2008, Proceedings of the National Academy of Sciences.
[26] W. Kaelin,et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. , 2008, Blood.
[27] K. Takeda,et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. , 2008, Blood.
[28] M. McMullin,et al. A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. , 2008, The New England journal of medicine.
[29] K. Kaushansky,et al. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. , 2007, Blood.
[30] W. Rathmell,et al. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. , 2007, The Journal of clinical investigation.
[31] K. Kivirikko,et al. An Endoplasmic Reticulum Transmembrane Prolyl 4-Hydroxylase Is Induced by Hypoxia and Acts on Hypoxia-inducible Factor α* , 2007, Journal of Biological Chemistry.
[32] M. McMullin,et al. A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. , 2007, Blood.
[33] J. Tisdale,et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. , 2007, Blood.
[34] K. Takeda,et al. Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System , 2007, Circulation.
[35] G. Camenisch,et al. Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins. , 2007, Antioxidants & redox signaling.
[36] E. Rankin,et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. , 2007, The Journal of clinical investigation.
[37] R. Johnson,et al. Acute postnatal ablation of Hif-2α results in anemia , 2007, Proceedings of the National Academy of Sciences.
[38] J. Fandrey,et al. Nitric Oxide Modulates Oxygen Sensing by Hypoxia-inducible Factor 1-dependent Induction of Prolyl Hydroxylase 2* , 2007, Journal of Biological Chemistry.
[39] K. Takeda,et al. Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2 , 2006, Molecular and Cellular Biology.
[40] Roland H Wenger,et al. Increased Prolyl 4-Hydroxylase Domain Proteins Compensate for Decreased Oxygen Levels , 2006, Journal of Biological Chemistry.
[41] Savita Khanna,et al. Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point. , 2006, Free radical biology & medicine.
[42] M. McMullin,et al. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[43] S. Perrotta,et al. Von Hippel-Lindau – dependent polycythemia is endemic on the island of Ischia : identification of a novel cluster , 2005 .
[44] R. DePinho,et al. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[45] C. Dalgard,et al. Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1* , 2005, Journal of Biological Chemistry.
[46] N. Oldham,et al. Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. , 2005, Molecular bioSystems.
[47] L. del Peso,et al. Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. , 2005, The Biochemical journal.
[48] J R Griffiths,et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. , 2005, Human molecular genetics.
[49] K. Kivirikko,et al. Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[50] H. Pagel,et al. Is the renal production of erythropoietin controlled by the brain stem? , 2005, American journal of physiology. Endocrinology and metabolism.
[51] G. Camenisch,et al. Copper-dependent activation of hypoxia-inducible factor ( HIF ) – 1 : implications for ceruloplasmin regulation , 2005 .
[52] Yuen-Li Chung,et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. , 2005, Cancer cell.
[53] W. Jelkmann,et al. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. , 2005, The Biochemical journal.
[54] J. Richardson,et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. , 2005, Blood.
[55] K. Maiese,et al. New avenues of exploration for erythropoietin. , 2005, JAMA.
[56] Fatima Mechta-Grigoriou,et al. JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress , 2004, Cell.
[57] A. Harris,et al. Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor* , 2004, Journal of Biological Chemistry.
[58] K. Eckardt,et al. Persistent induction of HIF‐1α and ‐2α in cardiomyocytes and stromal cells of ischemic myocardium , 2004 .
[59] V. Erdmann,et al. Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells , 2004 .
[60] W. Jelkmann,et al. Beneficial and ominous aspects of the pleiotropic action of erythropoietin , 2004, Annals of Hematology.
[61] P. Jaakkola,et al. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases. , 2004, The Biochemical journal.
[62] M. Wood,et al. Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors , 2004, Journal of cellular biochemistry.
[63] C. Dalgard,et al. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. , 2004, The Biochemical journal.
[64] K. Kivirikko,et al. Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases* , 2004, Journal of Biological Chemistry.
[65] J. D. Engel,et al. Hepatic Erythropoietin Gene Regulation by GATA-4* , 2004, Journal of Biological Chemistry.
[66] L. del Peso,et al. The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen* , 2003, Journal of Biological Chemistry.
[67] Christian Frelin,et al. Hypoxia Up-regulates Prolyl Hydroxylase Activity , 2003, Journal of Biological Chemistry.
[68] K. Kivirikko,et al. Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor* , 2003, Journal of Biological Chemistry.
[69] J. Pouysségur,et al. HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia , 2003, The EMBO journal.
[70] B. Brüne,et al. Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. , 2003, Molecular biology of the cell.
[71] G. Semenza,et al. Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia‐Reperfusion Injury , 2003, Circulation.
[72] A. Harris,et al. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. , 2003, Cancer research.
[73] B. Bowen,et al. Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. , 2003, Biochemical and biophysical research communications.
[74] W. Jelkmann,et al. Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing , 2003, Journal of Cell Science.
[75] Y. Fujii‐Kuriyama,et al. HLF/HIF‐2α is a key factor in retinopathy of prematurity in association with erythropoietin , 2003, The EMBO journal.
[76] J. Jelinek,et al. Mutations in the VHL gene in sporadic apparently congenital polycythemia. , 2003, Blood.
[77] David Mole,et al. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia , 2002, Nature Genetics.
[78] Y. Dor,et al. Activated pp60c-Src Leads to Elevated Hypoxia-inducible Factor (HIF)-1α Expression under Normoxia* , 2002, The Journal of Biological Chemistry.
[79] L. Rimsza,et al. Developmental changes in the expression of transcription factors GATA‐1, ‐2 and ‐3 during the onset of human medullary haematopoiesis , 2002, British journal of haematology.
[80] Jianhe Huang,et al. Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3* , 2002, The Journal of Biological Chemistry.
[81] Mircea Ivan,et al. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[82] J. Cheung,et al. Erythropoietin Modulates Calcium Influx through TRPC2* , 2002, The Journal of Biological Chemistry.
[83] Matthias Schramm,et al. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. , 2002, Biochemical and biophysical research communications.
[84] T. Iwanaga,et al. Epididymis is a novel site of erythropoietin production in mouse reproductive organs. , 2002, Biochemical and biophysical research communications.
[85] G. Semenza,et al. Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway* , 2002, The Journal of Biological Chemistry.
[86] R. Wenger,et al. Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[87] Christopher J Schofield,et al. Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family* , 2002, The Journal of Biological Chemistry.
[88] D. Peet,et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. , 2002, Genes & development.
[89] Till Acker,et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice , 2002, Nature Medicine.
[90] M. Seyfarth,et al. Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma. , 2002, Blood.
[91] N. Sang,et al. Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP , 2002, Molecular and Cellular Biology.
[92] N. Yaegashi,et al. Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle. , 2002, Molecular human reproduction.
[93] Kai-Uwe Eckardt,et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. , 2002, Journal of the American Society of Nephrology : JASN.
[94] D. Peet,et al. Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch , 2002, Science.
[95] K. Polyak,et al. Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression) , 2002, Oncogene.
[96] K. Flanders,et al. Erythropoietin receptor signalling is required for normal brain development. , 2002, Development.
[97] M. Gassmann,et al. Dissecting hypoxia‐dependent and hypoxia‐independent steps in the HIF‐1α activation cascade: implications for HIF‐1α gene therapy , 2001 .
[98] R. Brace,et al. Expression of erythropoietin mRNA, protein and receptor in ovine fetal membranes. , 2001, Placenta.
[99] G. Semenza,et al. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. , 2001 .
[100] S. McKnight,et al. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF , 2001, Science.
[101] Michael I. Wilson,et al. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.
[102] P. Ratcliffe,et al. Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation , 2001, The EMBO journal.
[103] S. Juul,et al. Erythropoietin acts as a trophic factor in neonatal rat intestine , 2001, Gut.
[104] J. Ihle,et al. The distal region and receptor tyrosines of the Epo receptor are non‐essential for in vivo erythropoiesis , 2001, The EMBO journal.
[105] G. Semenza,et al. HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression , 2001, Molecular and Cellular Biology.
[106] M. Gassmann,et al. Induction of HIF–1α in response to hypoxia is instantaneous , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[107] Michael I. Wilson,et al. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.
[108] H. Sucov,et al. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. , 2001, Genes & development.
[109] P. Lewczuk,et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[110] J. Fandrey,et al. Erythropoietin gene expression in different areas of the developing human central nervous system. , 2000, Brain research. Developmental brain research.
[111] S. Masuda,et al. Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. , 2000, American journal of physiology. Endocrinology and metabolism.
[112] M. Gassmann,et al. Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions. , 2000, Biochimica et biophysica acta.
[113] Eamonn R. Maher,et al. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein* , 2000, The Journal of Biological Chemistry.
[114] M. Gassmann,et al. Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation , 2000 .
[115] J. Peng,et al. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[116] E. Goldwasser,et al. A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene , 2000 .
[117] M. Ivan,et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein , 2000, Nature Cell Biology.
[118] S. Masuda,et al. The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner. , 2000, American journal of physiology. Endocrinology and metabolism.
[119] G. Semenza,et al. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[120] G. Semenza. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. , 2000, Journal of applied physiology.
[121] A. Koong,et al. Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.
[122] P. W. Conrad,et al. EPAS1 trans-Activation during Hypoxia Requires p42/p44 MAPK* , 1999, The Journal of Biological Chemistry.
[123] J. Pouysségur,et al. p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1* , 1999, The Journal of Biological Chemistry.
[124] M. Iruela-Arispe,et al. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. , 1999, Development.
[125] E. Mackenzie,et al. A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[126] C. Wykoff,et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.
[127] G. Semenza,et al. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. , 1999, Developmental biology.
[128] Y. Fujii‐Kuriyama,et al. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300 , 1999, The EMBO journal.
[129] Yuichi Makino,et al. Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway* , 1999, The Journal of Biological Chemistry.
[130] T. Beaty,et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. , 1999, The Journal of clinical investigation.
[131] P. Ratcliffe,et al. Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α* , 1999, The Journal of Biological Chemistry.
[132] L. Poellinger,et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α , 1998, The EMBO journal.
[133] J. Fandrey,et al. Erythropoietin mRNA Expression in Human Fetal and Neonatal Tissue , 1998 .
[134] R. Hammer,et al. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. , 1998, Genes & development.
[135] T. Harvey,et al. NMR structure of human erythropoietin and a comparison with its receptor bound conformation , 1998, Nature Structural Biology.
[136] S. Masuda,et al. Estrogen-dependent Production of Erythropoietin in Uterus and Its Implication in Uterine Angiogenesis* , 1998, The Journal of Biological Chemistry.
[137] L. Huang,et al. Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway , 1998 .
[138] Jessica Lo,et al. HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .
[139] Michael P. Brown,et al. Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.
[140] N. Miyasaka,et al. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. , 1998, Blood.
[141] A. Yoshimura,et al. Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization , 1998, FEBS letters.
[142] J. Marine,et al. Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors , 1998, Cell.
[143] A. Cumano,et al. Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis , 1998, Cell.
[144] E. Morishita,et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[145] K. Kivirikko,et al. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. , 1998, Matrix biology : journal of the International Society for Matrix Biology.
[146] M. Gassmann,et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. , 1998, Genes & development.
[147] E. Wintour,et al. Developmental regulation of erythropoietin and erythropoiesis. , 1997, American journal of physiology. Regulatory, integrative and comparative physiology.
[148] J. Caro,et al. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. , 1997, The Journal of biological chemistry.
[149] K. Eckardt,et al. Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats. , 1997, Kidney international.
[150] G. Semenza,et al. Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α , 1997, The Journal of Biological Chemistry.
[151] M. Bondurant,et al. The roles of Bcl-X(L) and apopain in the control of erythropoiesis by erythropoietin. , 1997, Blood.
[152] R. Snell,et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[153] H. Miyazaki,et al. Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia. , 1997, International journal of hematology.
[154] Warren S. Alexander,et al. A family of cytokine-inducible inhibitors of signalling , 1997, Nature.
[155] S. Akira,et al. Structure and function of a new STAT-induced STAT inhibitor , 1997, Nature.
[156] Takaho A. Endo,et al. A new protein containing an SH2 domain that inhibits JAK kinases , 1997, Nature.
[157] T. Senn,et al. Metabolism of thrombopoietin (TPO) in vivo: determination of the binding dynamics for TPO in mice. , 1997, Blood.
[158] A. Yoshimura,et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. , 1997, Blood.
[159] Y Fujii-Kuriyama,et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[160] Y. Miyakawa,et al. Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[161] H. Handa,et al. Characterization of the Human Thrombopoietin Gene Promoter , 1997, The Journal of Biological Chemistry.
[162] M. Nagao,et al. Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit* , 1997, The Journal of Biological Chemistry.
[163] R. Salgia,et al. Thrombopoietin induces activation of the phosphatidylinositol‐3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL , 1997, Journal of cellular physiology.
[164] W. Risau,et al. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels , 1997, Mechanisms of Development.
[165] S. Klinken,et al. Lyn tyrosine kinase is essential for erythropoietin‐induced differentiation of J2E erythroid cells , 1997, The EMBO journal.
[166] H. Lodish,et al. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[167] J. Hogenesch,et al. Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway* , 1997, The Journal of Biological Chemistry.
[168] V. Broudy,et al. Human platelets display high-affinity receptors for thrombopoietin. , 1997, Blood.
[169] W. Zhou,et al. Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. , 1997, Blood.
[170] T. Hirano,et al. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT , 1997, Oncogene.
[171] Y. Miura,et al. Negative regulation of the erythropoietin gene expression by the GATA transcription factors. , 1997, Blood.
[172] M. Gassmann,et al. The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive. , 1997, Kidney international.
[173] J. Iredale,et al. Sites of erythropoietin production. , 1997, Kidney international.
[174] D W Lübbers,et al. Heterogeneities and profiles of oxygen pressure in brain and kidney as examples of the pO2 distribution in the living tissue. , 1997, Kidney international.
[175] B. Ebert,et al. Oxygen regulated gene expression: erythropoietin as a model system. , 1997, Kidney international.
[176] L. Hennighausen,et al. Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.
[177] N. Miyasaka,et al. Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. , 1996, Blood.
[178] D. Livingston,et al. Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit* , 1996, The Journal of Biological Chemistry.
[179] E. Morishita,et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death , 1996, Neuroscience.
[180] E. Gordon-Smith,et al. Serum thrombopoietin levels in patients with aplastic anaemia , 1996, British journal of haematology.
[181] A. D’Andrea,et al. Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2. , 1996, Blood.
[182] S. Patel,et al. Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246. , 1996, Biochemistry.
[183] S. Bhattacharya,et al. An essential role for p300/CBP in the cellular response to hypoxia. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[184] M. Hokom,et al. The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis , 1996, British journal of haematology.
[185] S. Jacobsen,et al. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. , 1996, Blood.
[186] W. Kaelin,et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[187] W. Vainchenker,et al. Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis. , 1996, Blood.
[188] R. Klausner,et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[189] S. Koury,et al. Erythropoietin production by interstitial cells of hypoxic monkey kidneys , 1996, British journal of haematology.
[190] H. Beug,et al. Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[191] G. Semenza,et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.
[192] H. Makino,et al. Glomerular expression of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in patients with various forms of glomerulonephritis. , 1996, Laboratory investigation; a journal of technical methods and pathology.
[193] Lesley J. Murray,et al. Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin− primitive progenitor cells , 1996 .
[194] N. Mahmud,et al. Activity of the ligand for c‐mpl, thrombopoietin, in early haemopoiesis , 1996, British journal of haematology.
[195] H. Broxmeyer,et al. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. , 1996, Blood.
[196] F. Ishida,et al. Regulation of Serum Thrombopoietin Levels by Platelets and Megakaryocytes in Patients with Aplastic Anaemia and Idiopathic Thrombocytopenic Purpura , 1996, Thrombosis and Haemostasis.
[197] E. Morishita,et al. Anti-erythropoietin receptor monoclonal antibody: epitope mapping, quantification of the soluble receptor, and detection of the solubilized transmembrane receptor and the receptor-expressing cells. , 1996, Blood.
[198] A. Maxwell,et al. LOCALIZATION OF ERYTHROPOIETIN GENE EXPRESSION IN PROXIMAL RENAL TUBULAR CELLS DETECTED BY DIGOXIGENIN‐LABELLED OLIGONUCLEOTIDE PROBES , 1996, The Journal of pathology.
[199] T. Tsuruo,et al. Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA. , 1996, European journal of biochemistry.
[200] O. Hankinson,et al. The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression , 1996, The Journal of Biological Chemistry.
[201] A. Matsumoto,et al. A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders , 1996, British journal of haematology.
[202] H. Suliman,et al. Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues. , 1996, Gene.
[203] P Roth,et al. Colony stimulating factor‐1 expression is developmentally regulated in the mouse , 1996, Journal of leukocyte biology.
[204] N. Young,et al. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. , 1996, Blood.
[205] A. Ritchie,et al. Thrombopoietin Suppresses Apoptosis and Behaves as a Survival Factor for the Human Growth Factor‐Dependent Cell Line, M07e , 1996, Stem cells.
[206] K. Conrad,et al. Expression of erythropoietin by the human placenta , 1996 .
[207] B. Groner,et al. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. , 1996, The EMBO journal.
[208] A. Kurtz,et al. Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo , 1996, Pflügers Archiv.
[209] M. Gassmann,et al. Erythropoietin Gene Expression in Human, Monkey and Murine Brain , 1996, The European journal of neuroscience.
[210] M. Brizzi,et al. Effects of recombinant human megakaryocyte growth and development factor on platelet activation. , 1996, Blood.
[211] S. Busfield,et al. Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[212] A. Gurney,et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. , 1996, Blood.
[213] T. Nagasawa,et al. Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. , 1996, Blood.
[214] E. Friedman,et al. The intensity of hemodialysis and the response to erythropoietin in patients with end-stage renal disease. , 1996, The New England journal of medicine.
[215] F. D. de Sauvage,et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin , 1996, The Journal of experimental medicine.
[216] V. Broudy,et al. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. , 1996, Experimental hematology.
[217] I. Cavill,et al. How to diagnose and correct iron deficiency during r-huEPO therapy--a consensus report. , 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[218] V. D’Agati,et al. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. , 1996, Genes & development.
[219] B. Druker,et al. Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. , 1996, Blood.
[220] R. Skoda,et al. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. , 1996, Blood.
[221] K. Todokoro,et al. Thrombopoietin induces activation of at least two distinct signaling pathways , 1995, FEBS letters.
[222] P. Halloran,et al. Acute Renal Injury In The Interferon-γ Gene Knockout Mouse: Effect On Cytokine Gene Expression1 , 1995 .
[223] N. Komatsu,et al. Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line. , 1995, Biochemical and biophysical research communications.
[224] J. Chen,et al. Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. , 1995, Blood.
[225] T. Kato,et al. Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. , 1995, Experimental hematology.
[226] N. Fox,et al. Murine thrombopoietin mRNA levels are modulated by platelet count. , 1995, Blood.
[227] W. Parks,et al. In situ hybridization of human erythropoietin in pre- and postnatal kidneys. , 1995, Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association.
[228] J. Krosl,et al. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. , 1995, The EMBO journal.
[229] M. Okuma,et al. Thrombopoietin, c‐Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists‐induced aggregation in platelets in vitro , 1995, FEBS letters.
[230] J. Ihle. Cytokine receptor signalling , 1995, Nature.
[231] G. Krystal,et al. Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity (*) , 1995, The Journal of Biological Chemistry.
[232] Rudolf Jaenisch,et al. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor , 1995, Cell.
[233] E. Stanley,et al. Colony‐stimulating factor‐1 expression in the human fetus and newborn , 1995, Journal of leukocyte biology.
[234] H. Miyazaki,et al. Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors , 1995 .
[235] H. Lodish,et al. Interaction of the erythropoietin and stem-cell-factor receptors , 1995, Nature.
[236] V. Broudy,et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. , 1995, The Journal of clinical investigation.
[237] M. Remberger,et al. Cytokines in fetal blood and amniotic fluid in Rh‐immunized pregnancies , 1995, Obstetrics and gynecology.
[238] H. Lu,et al. Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. , 1995, Blood.
[239] F. Bazer,et al. Colony-stimulating factor-1 in conceptus and uterine tissues in pigs. , 1995, Biology of reproduction.
[240] T. Boone,et al. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. , 1995, Blood.
[241] J. Johnston,et al. Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2. , 1995, Blood.
[242] A. Gurney,et al. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[243] G. Semenza,et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[244] D. Levy,et al. Thrombopoietin activates a STAT5‐like factor in hematopoietic cells. , 1995, The EMBO journal.
[245] R. Rosenberg,et al. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. , 1995, Blood.
[246] S. Wickramasinghe,et al. Expression of an erythropoietin‐like gene in the trout , 1995, British journal of haematology.
[247] M. Gassmann,et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[248] V. Broudy,et al. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[249] T. Ogura,et al. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1 , 1995, Molecular and cellular biology.
[250] V. Broudy,et al. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. , 1995, Blood.
[251] Ursula Klingmüller,et al. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals , 1995, Cell.
[252] J. Griffin,et al. The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl (*) , 1995, The Journal of Biological Chemistry.
[253] A. Gurney,et al. Genomic Structure , Chromosomal Localization , and Conserved Alternative Splice Forms of Thrombopoietin , 2002 .
[254] W. Jelkmann,et al. Role of protein kinase C in hepatic erythropoietin synthesis. , 1995, Experimental hematology.
[255] E. Wintour,et al. Erythropoietin gene expression in fetal and adult sheep kidney , 1995, British journal of haematology.
[256] G. Semenza,et al. Purification and Characterization of Hypoxia-inducible Factor 1 (*) , 1995, The Journal of Biological Chemistry.
[257] J. Shutter,et al. Cloning and Characterization of the Human Megakaryocyte Growth and Development Factor (MGDF) Gene (*) , 1995, The Journal of Biological Chemistry.
[258] F. Grant,et al. Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[259] M. Rudnick,et al. Effects of recombinant human erythropoietin on renal function in chronic renal failure predialysis patients. , 1994, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[260] N. Seki,et al. Molecular cloning and chromosomal localization of the human thrombopoietin gene , 1994, FEBS letters.
[261] G. Semenza,et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. , 1994, The Journal of biological chemistry.
[262] P. Ratcliffe,et al. Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. , 1994, Blood.
[263] A. Gurney,et al. Thrombocytopenia in c-mpl-deficient mice. , 1994, Science.
[264] K. Yamagishi,et al. A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. , 1994, The Journal of biological chemistry.
[265] B. Ebert,et al. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[266] J. Loffing,et al. Distribution of ecto-5′-nucleotidase in the rat liver: effect of anaemia , 1994, Histochemistry.
[267] M. C. Hu,et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI , 1994, Cell.
[268] V. Broudy,et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin , 1994, Nature.
[269] Scott R. Presnell,et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo , 1994, Nature.
[270] William Vainchenker,et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis , 1994, Nature.
[271] D. Goeddel,et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand , 1994, Nature.
[272] H. Lodish,et al. Activation and inhibition of erythropoietin receptor function: role of receptor dimerization , 1994, Molecular and cellular biology.
[273] A. Anagnostou,et al. Erythropoietin receptor mRNA expression in human endothelial cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[274] R. Martino,et al. Postrenal transplant erythrocytosis: Further evidence implicating erythropoietin production by the native kidneys , 1994, Annals of Hematology.
[275] J. Spivak,et al. Serum immunoreactive erythropoietin during the perioperative period. , 1994, Surgery.
[276] H. Sato,et al. Levels of serum colony-stimulating factors (CSFs) in patients on long-term haemodialysis. , 1994, Cytokine.
[277] W. Jelkmann,et al. Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro. , 1994, Experimental hematology.
[278] G. Semenza,et al. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. , 1993, Blood.
[279] G. Remuzzi,et al. Reversible activation defect of the platelet glycoprotein IIb-IIIa complex in patients with uremia. , 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[280] P. Ratcliffe,et al. Identification of the renal erythropoietin-producing cells using transgenic mice. , 1993, Kidney international.
[281] G. Krystal,et al. Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. , 1993, Blood.
[282] J. Guénet,et al. Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. , 1993, Oncogene.
[283] J. Cook,et al. Serum form of the erythropoietin receptor identified by a sequence- specific peptide antibody [see comments] , 1993 .
[284] Franklin,et al. Erythropoietin structure-function relationships: high degree of sequence homology among mammals. , 1993, Blood.
[285] W. Vainchenker,et al. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. , 1993, Blood.
[286] O. Silvennoinen,et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.
[287] W. Hankins,et al. The functional form of the erythropoietin receptor is a 78-kDa protein: correlation with cell surface expression, endocytosis, and phosphorylation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[288] P. Leder,et al. Murine c‐mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. , 1993, The EMBO journal.
[289] P. Ratcliffe,et al. Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro , 1993, Pflügers Archiv.
[290] A. de la Chapelle,et al. Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[291] S. Masuda,et al. Effect of tunicamycin treatment on ligand binding to the erythropoietin receptor: conversion from two classes of binding sites to a single class. , 1993, Blood.
[292] H. Lodish,et al. Structure, function, and activation of the erythropoietin receptor. , 1993, Blood.
[293] P. Ratcliffe,et al. Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia. , 1993, Kidney international.
[294] M. Goldberg,et al. Modulators of protein kinase C inhibit hypoxia-induced erythropoietin production. , 1993, Experimental hematology.
[295] M. Le Hir,et al. Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[296] D. Rao,et al. Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia. , 1993, New England Journal of Medicine.
[297] D. Galson,et al. Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements , 1992, Molecular and cellular biology.
[298] G. Semenza,et al. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation , 1992, Molecular and cellular biology.
[299] P. Ratcliffe,et al. Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels. , 1992, The American journal of physiology.
[300] P. Ratcliffe,et al. Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. , 1992, The American journal of physiology.
[301] J. Adamson,et al. A comparison of the responses to recombinant human erythropoietin in normal and uremic subjects. , 1992, Kidney international.
[302] S. Koury,et al. Cellular sites of extrarenal and renal erythropoietin production in anaemic rats , 1992, British journal of haematology.
[303] M. Goldberg,et al. EFFECT OF INFLAMMATORY CYTOKINES ON HYPOXIA-INDUCED ERYTHROPOIETIN PRODUCTION , 1992 .
[304] P. Ratcliffe,et al. Age-dependent expression of the erythropoietin gene in rat liver and kidneys. , 1992, The Journal of clinical investigation.
[305] P. Ratcliffe,et al. Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys. , 1991, The American journal of physiology.
[306] R. W. Jones,et al. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[307] S. Antonarakis,et al. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[308] M. Goldberg,et al. Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein. , 1991, The Journal of biological chemistry.
[309] S. Koury,et al. Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney , 1991, Klinische Wochenschrift.
[310] K. Eckardt,et al. Serial immunoreactive erythropoietin levels in autologous blood donors , 1991, Transfusion.
[311] R. Weinmann,et al. Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. , 1991, The Journal of biological chemistry.
[312] P. Ratcliffe,et al. Organ distribution of erythropoietin messenger RNA in normal and uremic rats. , 1991, Kidney international.
[313] S. Antonarakis,et al. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[314] Mark J. Koury,et al. Localization of cells producing erythropoietin in murine liver by in situ hybridization , 1991 .
[315] W. Jelkmann,et al. Isolated serum-free perfused rat kidneys release immunoreactive erythropoietin in response to hypoxia. , 1991, Endocrinology.
[316] H. Scholz,et al. Oxygen-dependent erythropoietin production by the isolated perfused rat kidney , 1991, Pflügers Archiv.
[317] L. Zon,et al. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains , 1991, Molecular and cellular biology.
[318] J. Spivak,et al. Erythropoietin is both a mitogen and a survival factor. , 1991, Blood.
[319] M. Goldberg,et al. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. , 1991, Blood.
[320] F. Wendling,et al. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors , 1990, Cell.
[321] H. Lodish,et al. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity , 1990, Nature.
[322] H. Baumgaertl,et al. Evidence for a preglomerular oxygen diffusion shunt in rat renal cortex. , 1990, The American journal of physiology.
[323] D. Klassen,et al. Hepatitis-related hepatic erythropoietin production. , 1990, The American journal of medicine.
[324] A. Kurtz,et al. Multiple site estimates of erythropoietin and renin in polycythemic kidney transplant patients. , 1990, Transplantation.
[325] K. Eckardt,et al. Role of excretory graft function for erythropoietin formation after renal transplantation , 1990 .
[326] R. Mactier,et al. Effect of erythropoietin on anaemia in patients with myeloma receiving haemodialysis. , 1990, BMJ.
[327] J. Bazan,et al. Structural design and molecular evolution of a cytokine receptor superfamily. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[328] E. Goldwasser,et al. Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein. , 1990, The Journal of biological chemistry.
[329] R. Hakim,et al. Recombinant human erythropoietin and phlebotomy in the treatment of iron overload in chronic hemodialysis patients. , 1990, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[330] A. Anagnostou,et al. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[331] R. W. Jones,et al. Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection , 1990, The Journal of experimental medicine.
[332] T. McDonald,et al. Thrombopoietin derived from human embryonic kidney cells stimulates an increase in DNA content of murine megakaryocytes in vivo. , 1990, Experimental hematology.
[333] G. Bakris,et al. Effects of theophylline on erythropoietin production in normal subjects and in patients with erythrocytosis after renal transplantation. , 1990, The New England journal of medicine.
[334] C. March,et al. A new cytokine receptor superfamily. , 1990, Trends in biochemical sciences.
[335] A. D’Andrea,et al. Human erythropoietin receptor: cloning, expression, and biologic characterization. , 1990, Blood.
[336] L. Deaven,et al. The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p. , 1990, Blood.
[337] S. Piantadosi,et al. Decreased erythropoietin response in patients with the anemia of cancer. , 1990, The New England journal of medicine.
[338] H. Gisslinger,et al. Erythropoietin treatment of anemia associated with multiple myeloma. , 1990, The New England journal of medicine.
[339] K. Eckardt,et al. Decline of erythropoietin formation at continuous hypoxia is not due to feedback inhibition. , 1990, The American journal of physiology.
[340] M. Koury,et al. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. , 1990, Science.
[341] K. Eckardt,et al. Triggering of erythropoietin production by hypoxia is inhibited by respiratory and metabolic acidosis. , 1990, The American journal of physiology.
[342] S. Antonarakis,et al. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements , 1990, Molecular and cellular biology.
[343] N. Casadevall,et al. Tumor cells are the site of erythropoietin synthesis in human renal cancers associated with polycythemia. , 1990, Blood.
[344] J. Adamson,et al. Management of the anaemia of chronic renal failure with recombinant erythropoietin. , 1989, The Quarterly journal of medicine.
[345] L. Solomon,et al. Aluminum induced anemia: pathogenesis and treatment in patients on chronic hemodialysis. , 1989, Kidney international.
[346] B. Kaissling,et al. Distribution of 5′-nucleotidase in the renal interstitium of the rat , 1989, Cell and Tissue Research.
[347] H. Kozutsumi,et al. Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[348] H. Scholz,et al. Erythropoietin in polycystic kidneys. , 1989, The Journal of clinical investigation.
[349] T. Hirano,et al. Interleukin-6 is a potent thrombopoietic factor in vivo in mice. , 1989, Blood.
[350] M. Koury,et al. Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration , 1989 .
[351] J. Adamson,et al. Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. , 1989, The New England journal of medicine.
[352] H. Ward,et al. Serum erythropoietin levels after renal transplantation. , 1989, The New England journal of medicine.
[353] M. Le Hir,et al. Anemia induces 5'-nucleotidase in fibroblasts of cortical labyrinth of rat kidney. , 1989, Renal physiology and biochemistry.
[354] K. Sawada,et al. Receptors for erythropoietin in mouse and human erythroid cells and placenta. , 1989, Blood.
[355] T. Quinn,et al. Serum immunoreactive erythropoietin in HIV-infected patients. , 1989, JAMA.
[356] T. Pincus,et al. Treatment of the anemia of rheumatoid arthritis with recombinant human erythropoietin: clinical and in vitro studies. , 1989, Arthritis and rheumatism.
[357] S. Koury,et al. Human colony-forming units-erythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid development. , 1989, The Journal of clinical investigation.
[358] K. Eckardt,et al. Regulation of erythropoietin production is related to proximal tubular function. , 1989, The American journal of physiology.
[359] H. Lodish,et al. Expression cloning of the murine erythropoietin receptor , 1989, Cell.
[360] U Boutellier,et al. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. , 1989, Journal of applied physiology.
[361] S. Antonarakis,et al. Polycythemia in transgenic mice expressing the human erythropoietin gene. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[362] J. Royston,et al. Characterization of the anaemia of chronic renal failure and the mode of its correction by a preparation of human erythropoietin (r-HuEPO). An investigation of the pharmacokinetics of intravenous erythropoietin and its effects on erythrokinetics. , 1989, The Quarterly journal of medicine.
[363] L. Shultz,et al. Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev). , 1989, Experimental hematology.
[364] M. Goldberg,et al. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. , 1988, Science.
[365] M. Chandra,et al. Relation of serum erythropoietin levels to renal excretory function: evidence for lowered set point for erythropoietin production in chronic renal failure. , 1988, The Journal of pediatrics.
[366] A. Dell,et al. Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry. , 1988, Biochemistry.
[367] W. Jelkmann,et al. A comparison of the effects of renal artery constriction and anemia on the production of erythropoietin , 1988, Pflügers Archiv.
[368] K. Eckardt,et al. Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[369] M. Berridge,et al. Effects of recombinant human erythropoietin on megakaryocytes and on platelet production in the rat. , 1988, Blood.
[370] F. Marumo,et al. Clinical Effect of Recombinant Human Erythropoietin on Anemia Associated with Chronic Renal Failure. A Multiinstitutional Study in Japan , 1988, The International journal of artificial organs.
[371] L. Mailloux,et al. Serum erythropoietin levels and hematocrit in end-stage renal disease: influence of the mode of dialysis. , 1988, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[372] R. Meagher,et al. Modulation of erythropoietin production by adenosine. , 1988, The Journal of laboratory and clinical medicine.
[373] P. Thompson. CORONARY THROMBOLYSIS AND MYOCARDIAL SALVAGE BY TISSUE PLASMINOGEN ACTIVATOR , 1988, The Lancet.
[374] R. Sasaki,et al. Comparative structural study of N-linked oligosaccharides of urinary and recombinant erythropoietins. , 1988, Biochemistry.
[375] M. Koury,et al. Erythropoietin messenger RNA levels in developing mice and transfer of 125I-erythropoietin by the placenta. , 1988, The Journal of clinical investigation.
[376] J. Fisher,et al. Pharmacokinetics of erythropoietin in intact and anephric dogs. , 1988, The Journal of laboratory and clinical medicine.
[377] P. Altmann,et al. ALUMINIUM CHELATION THERAPY IN DIALYSIS PATIENTS: EVIDENCE FOR INHIBITION OF HAEMOGLOBIN SYNTHESIS BY LOW LEVELS OF ALUMINIUM , 1988, The Lancet.
[378] J. Adamson,et al. The anemia of end-stage renal disease: hematopoietic progenitor cell response. , 1988, Kidney international.
[379] H. Miyazaki,et al. Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells. , 1988, The Journal of biological chemistry.
[380] F. Wendling,et al. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. , 1988, The Journal of clinical investigation.
[381] M. Koury,et al. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. , 1988, Blood.
[382] Y. Kim,et al. Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. Identification of des-arginine 166 erythropoietin. , 1987, The Journal of biological chemistry.
[383] M A Goldberg,et al. The regulated expression of erythropoietin by two human hepatoma cell lines. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[384] T. McDonald. Regulation of Megakaryocytopoiesis by Thrombopoietin a , 1987, Annals of the New York Academy of Sciences.
[385] A. Besarab,et al. Dynamics of erythropoiesis following renal transplantation. , 1987, Kidney international.
[386] H. P. Davis. Pathology Prize Evening Polycythaemia following Renal Transplantation , 1987, Journal of the Royal Society of Medicine.
[387] A. Flake,et al. Erythropoietin production by the fetal liver in an adult environment. , 1987, Blood.
[388] J. Caro,et al. Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. , 1987, Blood.
[389] T. McDonald,et al. High doses of recombinant erythropoietin stimulate platelet production in mice. , 1987, Experimental hematology.
[390] J. Garcia,et al. Erythropoietin-hematocrit feedback circuit in the anemia of end-stage renal disease. , 1987, Kidney international.
[391] J. Caro,et al. Erythropoietin titers in anemic, nonuremic patients. , 1987, The Journal of laboratory and clinical medicine.
[392] J. Adamson,et al. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. , 1987, The New England journal of medicine.
[393] C. Winearls,et al. EFFECT OF HUMAN ERYTHROPOIETIN DERIVED FROM RECOMBINANT DNA ON THE ANAEMIA OF PATIENTS MAINTAINED BY CHRONIC HAEMODIALYSIS , 1986, The Lancet.
[394] K. Aoki,et al. Characterization and biological effects of recombinant human erythropoietin. , 1986, Immunobiology.
[395] C. H. Lin,et al. Chromosomal assignment of the human erythropoietin gene and its DNA polymorphism. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[396] S. Lewis,et al. Determination of serum immunoreactive erythropoietin in the investigation of erythrocytosis. , 1986, The New England journal of medicine.
[397] E. Goldwasser,et al. Expression of the erythropoietin gene. , 1986, Blood cells.
[398] M. Koury,et al. Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. , 1986, Molecular and cellular biology.
[399] J. Adamson,et al. Hematopoietic inhibitors in chronic renal failure: lack of in vitro specificity. , 1986, Kidney international.
[400] C. Shoemaker,et al. Murine erythropoietin gene: cloning, expression, and human gene homology , 1986, Molecular and cellular biology.
[401] G. Matzke,et al. Erythropoietin kinetics in rats: generation and clearance. , 1986, Blood.
[402] A. Grimes,et al. Correction of anaemia following renal transplantation: serial changes in serum immunoreactive erythropoietin, absolute reticulocyte count and red‐cell creatine levels , 1985, British journal of haematology.
[403] C. H. Lin,et al. Cloning and expression of the human erythropoietin gene. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[404] W. Kriz,et al. Morphologic and functional evidence for oxygen deficiency in the isolated perfused rat kidney. , 1985, Laboratory investigation; a journal of technical methods and pathology.
[405] J. Adamson,et al. Anemia of end-stage renal disease (ESRD). , 1985, Kidney international.
[406] J. Adamson,et al. Erythropoietin kinetics in normal and uremic sheep. , 1985, The Journal of laboratory and clinical medicine.
[407] J. Caro,et al. Uremic inhibitors of erythropoiesis. , 1985, Seminars in nephrology.
[408] E. Goldwasser,et al. The role of carbohydrate in erythropoietin action. , 1985, Endocrinology.
[409] R. Clouse,et al. Upper gastrointestinal bleeding in patients with chronic renal failure. , 1985, Annals of internal medicine.
[410] W. Jelkmann,et al. Erythropoietin production in normoxic and hypoxic rats with increased blood O2 affinity. , 1985, Respiration physiology.
[411] J. Mcmahon,et al. Erythropoietin secretion by isolated rat Kupffer cells. , 1984, Experimental hematology.
[412] J. Caro,et al. Biologic and immunologic erythropoietin in extracts from hypoxic whole rat kidneys and in their glomerular and tubular fractions. , 1984, The Journal of laboratory and clinical medicine.
[413] T. Hawkins,et al. IS ANAEMIA DURING CONTINUOUS AMBULATORY PERITONEAL DIALYSIS REALLY BETTER THAN DURING HAEMODIALYSIS? , 1983, The Lancet.
[414] H. Asaba,et al. Assessment of hemolysis in regular hemodialysis patients by measuring carbon monoxide production rate. , 1983, Clinical nephrology.
[415] T. McDonald,et al. Nephrectomy Abolishes the Increase in Small Acetylcholinesterase-Positive Immature Rat Megakaryocytes Induced by Acute Thrombocytopenia 1 , 1983, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[416] F. Thévenod,et al. Deficient feedback regulation of erythropoiesis in kidney transplant patients with polycythemia. , 1983, Kidney international.
[417] J. Savory,et al. ALUMINIUM POISONING: DIALYSIS ENCEPHALOPATHY, OSTEOMALACIA, AND ANAEMIA , 1983, The Lancet.
[418] B. Lacour,et al. Aluminium-induced, reversible microcytic anemia in chronic renal failure: clinical and experimental studies. , 1983, Clinical nephrology.
[419] N. Lameire,et al. Influence of continuous ambulatory peritoneal dialysis on the anemia of endstage renal disease. , 1983, Kidney international.
[420] T. McDonald,et al. Effects of thrombopoietin on the number and diameter of marrow megakaryocytes of mice. , 1983, Experimental hematology.
[421] Marilyn E. Miller,et al. Plasma levels of immunoreactive erythropoietin after acute blood loss in man , 1982, British journal of haematology.
[422] J. Fisher,et al. A radioimmunoassay for erythropoietin: serum levels in normal human subjects and patients with hemopoietic disorders. , 1982, The Journal of laboratory and clinical medicine.
[423] J. Kark,et al. Erythrocytosis in patients on long-term hemodialysis. , 1982, Annals of internal medicine.
[424] P. Cotes,et al. RAPID COMMUNICATION: DIURNAL VARIATION OF SERUM IMMUNOREACTIVE ERYTHROPOIETIN IN A NORMAL SUBJECT , 1982 .
[425] W. Jelkmann. Temporal pattern of erythropoietin titers in kidney tissue during hypoxic hypoxia , 1982, Pflügers Archiv.
[426] P. Cotes. I. EVIDENCE FOR THE VALIDITY OF THE ASSAY METHOD AND THE PHYSIOLOGICAL RELEVANCE OF ESTIMATES , 1982, British journal of haematology.
[427] Cotes Pm. Immunoreactive erythropoietin in serum. I. Evidence for the validity of the assay method and the physiological relevance of estimates. , 1982 .
[428] W. Jelkmann,et al. Demonstration of high levels of erythropoietin in rat kidneys following hypoxic hypoxia , 1981, Pflügers Archiv.
[429] J. Winchester,et al. Hemosiderosis in hemodialysis patients. , 1981, JAMA.
[430] J. Fisher,et al. Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure. , 1981, The Journal of clinical investigation.
[431] E. Cronkite,et al. Regulatory mechanism of erythropoietin production: effects of hypoxemia and hypercarbia. , 1981, Experimental hematology.
[432] E. Zanjani,et al. Studies on the liver to kidney switch of erythropoietin production. , 1981, The Journal of clinical investigation.
[433] Wallner Sf,et al. Evidence that inhibition of erythropoiesis is important in the anemia of chronic renal failure. , 1981 .
[434] B. Bacon,et al. Renal artery stenosis with erythrocytosis after renal transplantation. , 1980, Archives of internal medicine.
[435] G. Barbour. Effect of parathyroidectomy on anemia in chronic renal failure. , 1979, Archives of internal medicine.
[436] S. Ebbe. Experimental and clinical megakaryocytopoiesis. , 1979, Clinics in haematology.
[437] F. Dagher,et al. ARE THE NATIVE KIDNEYS RESPONSIBLE FOR ERYTHROCYTOSIS IN RENAL ALLORECIPIENTS? , 1979, Transplantation.
[438] J. Caro,et al. Erythropoietin levels in uremic nephric and anephric patients. , 1979, The Journal of laboratory and clinical medicine.
[439] M. Sohtell,et al. CO2 along the proximal tubules in the rat kidney. , 1979, Acta physiologica Scandinavica.
[440] P. Jungers,et al. Anemia and secondary hyperparathyroidism. , 1978, Archives of internal medicine.
[441] M. Szmitkowski,et al. Distribution of CSF (colony stimulating factor) in kidney of the mouse , 1978, Experientia.
[442] E. Mirand,et al. Carbon dioxide effects on erythropoietin and erythropoiesis. , 1978, The Journal of laboratory and clinical medicine.
[443] B. Pollara,et al. Localization of an adenosine deaminase-binding protein in human kidney. , 1978, The Journal of laboratory and clinical medicine.
[444] E. Goldwasser,et al. Extraction of erythropoietin from normal kidneys. , 1978, Endocrinology.
[445] S. Wallner,et al. The effect of serum from patients with chronic renal failure on erythroid colony growth in vitro. , 1978, The Journal of laboratory and clinical medicine.
[446] J. Schooley,et al. Inhibition of erythropoietin production in unanesthetized rabbits exposed to an acute hypoxic-hypercapnic environment. , 1978, Blood.
[447] C. Peschle,et al. Role of the hypophysis in erythropoietin production during hypoxia. , 1978, Blood.
[448] J. Cook,et al. Iron balance in hemodialysis patients. , 1977, Annals of internal medicine.
[449] E. Mirand,et al. Identification of erythropoietin producing cells in fetal mouse liver cultures. , 1977, Experimental hematology.
[450] E. Goldwasser,et al. Purification of human erythropoietin. , 1977, The Journal of biological chemistry.
[451] J. Bergström,et al. Hypersequestration of 51Cr-labelled erythrocytes as a criterion for splenectomy in regular hemodialysis patients. , 1977, Clinical nephrology.
[452] G. Beynon. The influence of the autonomic nervous system in the control of erythropoietin secretion in the hypoxic rat. , 1977, The Journal of physiology.
[453] J. Levin,et al. Relationships between thrombopoiesis and erythropoiesis: with studies of the effects of preparations of thrombopoietin and erythropoietin , 1976 .
[454] R. E. Smith,et al. Primary hyperparathyroidism and anemia. , 1976, Archives of internal medicine.
[455] G. Pampiglione,et al. INFANTILE SPASMS AND SUBSEQUENT APPEARANCE OF TUBEROUS SCLEROSIS SYNDROME , 1975, The Lancet.
[456] Penington Dg,et al. The effect of massive liver resection on platelet kinetics in the rat. , 1975 .
[457] Y. Yawata,et al. Abnormal red cell metabolism in patients with chronic uremia: Nature of the defect and its persistence despite adequate hemodialysis. , 1975, Blood.
[458] E. Goldwasser,et al. On the mechanism of erythropoietin-induced differentiation. 13. The role of sialic acid in erythropoietin action. , 1974, The Journal of biological chemistry.
[459] J. Schooley,et al. Extrarenal Erythropoietin Production by the Liver in the Weanling Rat 1 , 1974, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[460] O. Jonasson,et al. The hematologic effect of androgen in uremic patients. Study of packed cell volume and erythropoietin responses. , 1973, Annals of internal medicine.
[461] P. Hochstein,et al. Erythrocyte deformability in uremic hemodialyzed patients. , 1973, Annals of internal medicine.
[462] J. A. Harris,et al. Erythropoietin production in dogs exposed to high altitude and carbon monoxide. , 1973, The American journal of physiology.
[463] J. Koplan,et al. Erythropoietin-producing renal cyst and polycythemia vera. Clarification of their relationship. , 1973, The American journal of medicine.
[464] K. Møllgård,et al. Evidence against erythropoietin production by the carotid body. , 1973, Respiration physiology.
[465] W. Fried. The liver as a source of extrarenal erythropoietin production. , 1972, Blood.
[466] J. Fisher,et al. Plasma Disappearance of 125I-Labeled Erythropoietin in Anesthetized Rabbits 1 , 1972, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[467] R. H. Painter,et al. Studies on the role of sialic acid in the physical and biological properties of erythropoietin. , 1972, Canadian journal of biochemistry.
[468] E. Nečas,et al. Unresponsiveness of erythropoietin-producing cells to cyanide. , 1972, American Journal of Physiology.
[469] C. Peschle,et al. Mechanism of thyroxine action on erythropoiesis. , 1971, Endocrinology.
[470] E. Nečas,et al. Feedback regulation by red cell mass of the sensitivity of the erythropoietin-producing organ to hypoxia. , 1970, Blood.
[471] J. Adamson,et al. Disorders of red blood cell production in uremia. , 1970, Archives of internal medicine.
[472] M. Gross,et al. On the mechanism of erythropoietin-induced differentiation. VII. The relationship between stimulated deoxyribonucleic acid synthesis and ribonucleic acid synthesis. , 1970, The Journal of biological chemistry.
[473] R. Alexanian,et al. Erythropoietin and erythropoiesis in anemic man following androgens. , 1969, Blood.
[474] D. Howard,et al. Regulation of erythropoiesis. XXII. Erythropoietin production in the newborn animal. , 1968, Blood.
[475] J. Fisher,et al. Erythropoietin production in nephrectomized and hypophysectomized animals. , 1968, The American journal of physiology.
[476] J W Fisher,et al. Relationship Between Renal Blood Flow and Erythropoietin Production In Dogs.∗ , 1967, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[477] D. Penington,et al. Regulation of Platelet Production: ‘Hypersplenism’ in the Experimental Animal , 1967, British journal of haematology.
[478] J. Adamson,et al. Erythropoiesis in patients with renal failure undergoing chronic dialysis. , 1967, The New England journal of medicine.
[479] C. Reynafarje,et al. Humoral Control of Erythropoietic Activity in Man During and After Altitude Exposure.∗ , 1964, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[480] J. Krog,et al. Renal Oxygen Tension , 1960, Nature.
[481] H. Borsook,et al. Inactivation of Erythropoietin by Neuraminidase and by Mild Substitution Reactions , 1960, Nature.
[482] E. Goldwasser,et al. Role of the Kidney in Erythropoiesis , 1957, Nature.
[483] R. Blattner. Physiologic control of red cell production , 1956 .
[484] A. Erslev,et al. Humoral regulation of red cell production. , 1953, Blood.
[485] K. Reissmann. Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. , 1950, Blood.
[486] E. Bonsdorff,et al. A Humoral Mechanism in Anoxic Erythrocytosis , 1948 .
[487] D. Barber,et al. Cytokine Receptor Signaling , 2010 .
[488] D. Chae,et al. Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney. , 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[489] J. Prchal,et al. The HIF2A gene in familial erythrocytosis. , 2008, The New England journal of medicine.
[490] M. Charbonneau,et al. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. , 2006, The Journal of biological chemistry.
[491] R. Gatti,et al. Congenital polycythemia with homozygous and heterozygous mutations of von Hippel-Lindau gene: five new Caucasian patients. , 2005, Haematologica.
[492] David G. Watson,et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.
[493] K. Eckardt,et al. Regulation of erythropoietin production. , 2005, European journal of clinical investigation.
[494] D. Fabbro,et al. Hypoxia-induced accumulation of erythropoietin mRNA in isolated hepatocytes is inhibited by protein kinase C , 2004, Pflügers Archiv.
[495] M. Gassmann,et al. Non-erythroid functions of erythropoietin. , 2003, Advances in experimental medicine and biology.
[496] S. Bhattacharya,et al. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. , 1999, Genes & development.
[497] Yan Li,et al. Erythropoietin and Erythropoietin Receptor in the Developing Human Central Nervous System , 1998, Pediatric Research.
[498] D. Williams,et al. Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis. , 1998, Blood.
[499] L. Wartman,et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. , 1998, Gene expression.
[500] Peter Beighton,et al. de la Chapelle, A. , 1997 .
[501] B. Chong,et al. Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. , 1997, Blood.
[502] S. McKnight,et al. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. , 1997, Genes & development.
[503] D Grillot,et al. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. , 1996, Blood.
[504] W. Szewczyk,et al. Erythropoietin concentration in cyst fluid in patients with simple renal cysts. , 1994, Nephron.
[505] K. Mizuno,et al. Direct evidence for erythropoietin-induced release of endothelin from peripheral vascular tissue. , 1994, Life sciences.
[506] D. K. Ganguly,et al. Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility. , 1994, Life sciences.
[507] P. Ratcliffe,et al. Increased plasma viscosity as a reason for inappropriate erythropoietin formation. , 1993, The Journal of clinical investigation.
[508] G. Longmore. Erythropoietin receptor mutations and Olympic glory , 1993, Nature Genetics.
[509] C. Pérez-Carral,et al. Anaphylactic reaction to recombinant human erythropoietin. , 1993, Nephron.
[510] H. Rodemann,et al. Human renal tubular cells as a cytokine source: PDGF-B, GM-CSF and IL-6 mRNA expression in vitro. , 1993, Experimental nephrology.
[511] J. Fandrey,et al. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. , 1993, Blood.
[512] W. Jelkmann,et al. Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys. , 1992, Life sciences.
[513] C. Bernis,et al. Erythrocytosis after renal transplantation. , 1991, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[514] N. Muirhead,et al. The role of aluminium and parathyroid hormone in erythropoietin resistance in haemodialysis patients. , 1991, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[515] P. Lisi,et al. Separation of carbohydrate-mediated microheterogeneity of recombinant human erythropoietin by free solution capillary electrophoresis. Effects of pH, buffer type and organic additives. , 1991, Journal of chromatography.
[516] W. Jelkmann,et al. Modulation of the production of erythropoietin by cytokines: in vitro studies and their clinical implications. , 1990, Contributions to nephrology.
[517] G. Nyberg,et al. Erythrocytosis after renal transplantation; treatment by removal of the native kidneys. , 1990, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[518] K. Eckardt,et al. Single-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure. , 1989, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[519] M. Le Hir,et al. Site of erythropoietin formation. , 1989, Contributions to nephrology.
[520] M. Berridge,et al. Expression of specific high-affinity binding sites for erythropoietin on rat and mouse megakaryocytes. , 1989, Experimental hematology.
[521] R. Weinmann,et al. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. , 1989, Blood.
[522] A. Bidani,et al. Kinetics of CO2 exchange in the kidney. , 1988, Annual review of physiology.
[523] J. Fisher,et al. A1 and A2 adenosine receptor regulation of erythropoietin production. , 1988, Life sciences.
[524] M. Koury,et al. Erythropoietin control of terminal erythroid differentiation: maintenance of cell viability, production of hemoglobin, and development of the erythrocyte membrane. , 1987, Blood cells.
[525] J. Adamson,et al. Spermine and spermidine are non-specific inhibitors of in vitro hematopoiesis. , 1987, Kidney international.
[526] J. Garcia,et al. Immunoreactive erythropoietin studies in hypoxic rats and the role of the salivary glands. , 1987, Experimental hematology.
[527] R. Eddy,et al. Regional assignment of the erythropoietin gene to human chromosome region 7pter----q22. , 1986, Cytogenetics and cell genetics.
[528] M. Miller,et al. Serum immunoreactive erythropoietin levels in patients with polycystic kidney disease as compared with other hemodialysis patients. , 1985, Nephron.
[529] E. Fritsch,et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin , 1985, Nature.
[530] M. Brezis,et al. Selective vulnerability of the medullary thick ascending limb to anoxia in the isolated perfused rat kidney. , 1984, The Journal of clinical investigation.
[531] J. Caro,et al. Pure erythrocytosis classified according to erythropoietin titers. , 1984, The American journal of medicine.
[532] S. Hopfer,et al. Erythropoietin-mediated erythrocytosis in rodents after intrarenal injection of nickel subsulfide. , 1982, The Yale journal of biology and medicine.
[533] W. Fried,et al. Detection of high erythropoietin titers in renal extracts of hypoxic rats. , 1981, The Journal of laboratory and clinical medicine.
[534] J. Fisher. Mechanism of the anemia of chronic renal failure. , 1980, Nephron.
[535] W. Clark,et al. Correctable factors contributing to the anemia of dialysis patients. , 1977, Nephron.
[536] E. Sabbaga,et al. Polycythemia after Kidney Transplantation , 1977 .
[537] E. Nečas,et al. Species specificity of guinea pig erythropoietin. , 1976, Endocrinologia experimentalis.
[538] Mcdonald Tp. Role of the kidneys in thrombopoietin production. , 1976 .
[539] G. Barlow,et al. Thrombopoietin production by human embryonic kidney cells in culture. , 1975, The Journal of laboratory and clinical medicine.
[540] T. Berne,et al. Hypersplenism in the Uremic Hemodialyzed Patient , 1972 .
[541] P. Abbrecht,et al. Plasma erythropoietin in men and mice during acclimatization to different altitudes. , 1972, Journal of applied physiology.
[542] S. Halvorsen. Effects of growth hormone on erythropoiesis in the intact rabbit and the polycythemic mouse. , 1966, Acta physiologica Scandinavica.
[543] T. J. Mcmanus,et al. AN ION TRANSPORT DEFECT IN ERYTHROCYTES FROM UREMIC PATIENTS. , 1964, Transactions of the Association of American Physicians.
[544] F. Stohlman. REGULATION OF ERYTHROPOIESIS , 1962 .
[545] E. Goldwasser,et al. Studies on erythropoiesis. V. The effect of cobalt on the production of erythropoietin. , 1958, Blood.
[546] E. Bonsdorff. On the presence of erythropoietins in the plasma from sheep foetuses during the latter half of gestation. , 1949, Acta physiologica Scandinavica.