Challenges in neural interface electronics: miniaturization and wireless operation

Abstract This chapter covers the basics and challenges in electronic circuits needed for neural recording and stimulation to realize wireless and batteryless implants in small size. Long operation distance, high bandwidth and processing capability, and low power densities are desired. However, meeting these in a small batteryless system remains a big design challenge. Important aspects of these implants, namely, equivalent electrical circuit model of neural microelectrode arrays, analog front end of the interface electronics for recording, circuit block for stimulation, integrated on-chip microprocessing, programmability, and wireless power and data transfer are discussed in this chapter. Radio frequency, optical, and ultrasonic methods are emphasized as viable solutions for wireless operation.

[1]  Jan M. Rabaey,et al.  Reliable Next-Generation Cortical Interfaces for Chronic Brain–Machine Interfaces and Neuroscience , 2017, Proceedings of the IEEE.

[2]  P. Nikitin,et al.  Antenna design for UHF RFID tags: a review and a practical application , 2005, IEEE Transactions on Antennas and Propagation.

[3]  Elad Alon,et al.  Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust , 2016, Neuron.

[4]  David Blaauw,et al.  A millimeter-scale wireless imaging system with continuous motion detection and energy harvesting , 2014, 2014 Symposium on VLSI Circuits Digest of Technical Papers.

[5]  Seok Hyun Yun,et al.  Light in diagnosis, therapy and surgery , 2016, Nature Biomedical Engineering.

[6]  A. N. Bashkatov,et al.  Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm , 2005 .

[7]  Daryl R. Kipke CNS Recording: Devices and Techniques , 2017 .

[8]  K. Najafi,et al.  Energy Scavenging From Low-Frequency Vibrations by Using Frequency Up-Conversion for Wireless Sensor Applications , 2008, IEEE Sensors Journal.

[9]  Benjamin C. Johnson,et al.  A wireless millimetre-scale implantable neural stimulator with ultrasonically powered bidirectional communication , 2020, Nature Biomedical Engineering.

[10]  Iskender Haydaroglu,et al.  Optically Powered Optical Transmitter Using a Single Light-Emitting Diode , 2017, IEEE Transactions on Circuits and Systems I: Regular Papers.

[11]  Anantha Chandrakasan,et al.  A Battery-Less Thermoelectric Energy Harvesting Interface Circuit With 35 mV Startup Voltage , 2010, IEEE Journal of Solid-State Circuits.

[12]  Elad Alon,et al.  Model validation of untethered, ultrasonic neural dust motes for cortical recording , 2015, Journal of Neuroscience Methods.

[13]  G. Buzsáki,et al.  Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals , 2015, Neuron.

[14]  Joseph M. Kahn,et al.  An autonomous 16 mm/sup 3/ solar-powered node for distributed wireless sensor networks , 2002, Proceedings of IEEE Sensors.

[15]  Eli Yablonovitch,et al.  Strong Internal and External Luminescence as Solar Cells Approach the Shockley–Queisser Limit , 2012, IEEE Journal of Photovoltaics.

[16]  Jan M. Rabaey,et al.  A Fully-Integrated, Miniaturized (0.125 mm²) 10.5 µW Wireless Neural Sensor , 2013, IEEE Journal of Solid-State Circuits.

[17]  Pedram Mohseni,et al.  A Battery-Powered Activity-Dependent Intracortical Microstimulation IC for Brain-Machine-Brain Interface , 2011, IEEE Journal of Solid-State Circuits.

[18]  Yao Lu,et al.  Wireless Neurosensor for Full-Spectrum Electrophysiology Recordings during Free Behavior , 2014, Neuron.

[19]  Andreas Ostendorf,et al.  Optical screw-wrench for microassembly , 2017, Microsystems & Nanoengineering.

[20]  David Blaauw,et al.  Subcutaneous Photovoltaic Infrared Energy Harvesting for Bio-implantable Devices , 2017, IEEE Transactions on Electron Devices.

[21]  Iskender Haydaroglu,et al.  Optical Power Delivery and Data Transmission in a Wireless and Batteryless Microsystem Using a Single Light Emitting Diode , 2015, Journal of Microelectromechanical Systems.

[22]  Erick O. Torres,et al.  Electrostatic Energy-Harvesting and Battery-Charging CMOS System Prototype , 2009, IEEE Transactions on Circuits and Systems I: Regular Papers.

[23]  T. N. Gevrek,et al.  Expanding the versatility of poly(dimethylsiloxane) through polymeric modification: an effective approach for improving triboelectric energy harvesting performance , 2020, Smart Materials and Structures.

[24]  M. Jamal,et al.  Tetherless Microgrippers With Transponder Tags , 2011, Journal of Microelectromechanical Systems.

[25]  Liming Wang,et al.  An artificial intelligence platform for the multihospital collaborative management of congenital cataracts , 2017, Nature Biomedical Engineering.

[26]  A. Sher,et al.  Photovoltaic Retinal Prosthesis with High Pixel Density , 2012, Nature Photonics.

[27]  Maysam Ghovanloo,et al.  An Inductively-Powered Wireless Neural Recording and Stimulation System for Freely-Behaving Animals , 2019, IEEE Transactions on Biomedical Circuits and Systems.

[28]  Ieee Standards Board IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields, 3kHz to 300 GHz , 1992 .

[29]  Maysam Ghovanloo,et al.  Robust Wireless Power Transmission to mm-Sized Free-Floating Distributed Implants , 2017, IEEE Transactions on Biomedical Circuits and Systems.

[30]  David Blaauw,et al.  A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain–machine interfaces , 2020, Nature Biomedical Engineering.

[31]  A. Yalçinkaya,et al.  Optoelectronic CMOS Power Supply Unit for Electrically Isolated Microscale Applications , 2011, IEEE Journal of Selected Topics in Quantum Electronics.

[32]  Teresa H. Y. Meng,et al.  A mm-sized implantable power receiver with adaptive link compensation , 2009, 2009 IEEE International Solid-State Circuits Conference - Digest of Technical Papers.

[33]  Michael P. Flynn,et al.  A 64 Channel Programmable Closed-Loop Neurostimulator With 8 Channel Neural Amplifier and Logarithmic ADC , 2010, IEEE Journal of Solid-State Circuits.

[34]  Ying Yao,et al.  An Implantable 64-Channel Wireless Microsystem for Single-Unit Neural Recording , 2009, IEEE Journal of Solid-State Circuits.

[35]  Elad Alon,et al.  Neural Dust: An Ultrasonic, Low Power Solution for Chronic Brain-Machine Interfaces , 2013, 1307.2196.

[36]  David Blaauw,et al.  Circuit Design Advances for Wireless Sensing Applications , 2010, Proceedings of the IEEE.

[37]  Joseph A Potkay,et al.  Long term, implantable blood pressure monitoring systems , 2008, Biomedical microdevices.

[38]  David Blaauw,et al.  A Modular 1 mm$^{3}$ Die-Stacked Sensing Platform With Low Power I$^{2}$C Inter-Die Communication and Multi-Modal Energy Harvesting , 2013, IEEE Journal of Solid-State Circuits.

[39]  Nicolas Y. Masse,et al.  Reach and grasp by people with tetraplegia using a neurally controlled robotic arm , 2012, Nature.

[40]  J. Tuovinen,et al.  Millimeter-Wave Identification—A New Short-Range Radio System for Low-Power High Data-Rate Applications , 2008, IEEE Transactions on Microwave Theory and Techniques.

[41]  David Blaauw,et al.  A 0.04MM316NW Wireless and Batteryless Sensor System with Integrated Cortex-M0+ Processor and Optical Communication for Cellular Temperature Measurement , 2018, 2018 IEEE Symposium on VLSI Circuits.

[42]  Christoph Huber,et al.  The first batteryless, solar-powered cardiac pacemaker. , 2015, Heart rhythm.

[43]  Yu Hong,et al.  A flexible microsystem capable of controlled motion and actuation by wireless power transfer , 2020 .

[44]  D. E. Hudson,et al.  Penetration of laser light at 808 and 980 nm in bovine tissue samples. , 2013, Photomedicine and laser surgery.

[45]  Maysam Ghovanloo,et al.  A modular 32-site wireless neural stimulation microsystem , 2004 .

[46]  P. McEuen,et al.  Microscopic sensors using optical wireless integrated circuits , 2020, Proceedings of the National Academy of Sciences.

[47]  M. Allen,et al.  Micromachined endovascularly-implantable wireless aneurysm pressure sensors: from concept to clinic , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[48]  Günhan Dündar,et al.  An Optically Powered CMOS Receiver System for Intravascular Magnetic Resonance Applications , 2012, IEEE Journal on Emerging and Selected Topics in Circuits and Systems.

[49]  Daryl R. Kipke,et al.  Wireless implantable microsystems: high-density electronic interfaces to the nervous system , 2004, Proceedings of the IEEE.

[50]  K.D. Wise Wireless implantable microsystems: coming breakthroughs in health care , 2002, 2002 Symposium on VLSI Circuits. Digest of Technical Papers (Cat. No.02CH37302).

[51]  Kristofer S. J. Pister,et al.  SoC Issues for RF Smart Dust , 2006, Proceedings of the IEEE.

[52]  Shuqing He,et al.  Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles. , 2015, Chemical communications.

[53]  Euisik Yoon,et al.  State-of-the-art MEMS and microsystem tools for brain research , 2017, Microsystems & Nanoengineering.

[54]  Yuji Tanabe,et al.  Wireless power transfer to deep-tissue microimplants , 2014, Proceedings of the National Academy of Sciences.

[55]  K. Wise,et al.  A wireless microsystem for the remote sensing of pressure, temperature, and relative humidity , 2005, Journal of Microelectromechanical Systems.

[56]  David Blaauw,et al.  A cubic-millimeter energy-autonomous wireless intraocular pressure monitor , 2011, 2011 IEEE International Solid-State Circuits Conference.

[57]  Paul L. McEuen,et al.  A 250 μm × 57 μm Microscale Opto-electronically Transduced Electrodes (MOTEs) for Neural Recording , 2018, IEEE Transactions on Biomedical Circuits and Systems.

[58]  Soichi Watanabe,et al.  ICNIRP Guidelines on Limits of Exposure to Laser Radiation of Wavelengths between 180 nm and 1,000 μm. , 2013, Health physics.

[59]  Jan M. Rabaey,et al.  A Minimally Invasive 64-Channel Wireless μECoG Implant , 2015, IEEE Journal of Solid-State Circuits.

[60]  Jon A. Mukand,et al.  Neuronal ensemble control of prosthetic devices by a human with tetraplegia , 2006, Nature.