Q: Is it safe to continue biologic agents during surgery in patients with inflammatory bowel disease?

Patients with inflammatory bowel disease who are taking monoclonal antibodies against tumor necrosis factor alpha (TNF), interleukins 12 and 23, or integrin can continue taking them around the time of surgery, but small-molecule drugs such as tofacitinib should be withheld. Inflammatory bowel

[1]  Jessica Rosenberg,et al.  Tofacitinib for the treatment of ulcerative colitis: A review of the literature , 2019, World Journal of Meta-Analysis.

[2]  P. Higgins,et al.  415a – Anti-Tumor Necrosis Factor Therapy is Not Associated with Post-Operative Infection: Results from Prospective Cohort of Ulcerative Colitis and Crohn's Disease Patients Undergoing Surgery to Identify Risk Factors for Postoperative Infection I (Puccini) , 2019, Gastroenterology.

[3]  Gang Liu,et al.  Meta-Analysis: The Influence of Preoperative Infliximab Use on Postoperative Complications of Crohn's Disease. , 2018, Inflammatory bowel diseases.

[4]  Anastasios Koulaouzidis,et al.  Systematic Review and Meta-analysis: Vedolizumab and Postoperative Complications in Inflammatory Bowel Disease. , 2018, Inflammatory bowel diseases.

[5]  G. Kaplan,et al.  Preoperative Ustekinumab Treatment Is Not Associated With Increased Postoperative Complications in Crohn’s Disease: A Canadian Multi-Centre Observational Cohort Study , 2018, Journal of the Canadian Association of Gastroenterology.

[6]  J. Colombel,et al.  Systematic Review and Meta-Analysis: Preoperative Vedolizumab Treatment and Postoperative Complications in Patients with Inflammatory Bowel Disease , 2018, Journal of Crohn's & colitis.

[7]  A. Lightner.  Perioperative Management of Biologic and Immunosuppressive Medications in Patients With Crohn’s Disease , 2018, Diseases of the colon and rectum.

[8]  N. Hyman,et al.  Postoperative Outcomes in Ustekinumab-Treated Patients Undergoing Abdominal Operations for Crohn’s Disease , 2018, Journal of Crohn's & colitis.

[9]  G. Guyatt,et al.  2017 American College of Rheumatology / American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty , 2017 .

[10]  G. Kaplan,et al.  Preoperative Ustekinumab Treatment is not Associated with Increased Postoperative Complications in crohn's Disease: A Canadian Multicentre Case–Control Cohort Study , 2017 .

[11]  U. Kopylov,et al.  Preoperative optimization of patients with inflammatory bowel disease undergoing gastrointestinal surgery: a systematic review , 2016, International Journal of Colorectal Disease.

[12]  U. Ali,et al.  Impact of Preoperative Immunosuppressive Agents on Postoperative Outcomes in Crohn’s Disease , 2014, Diseases of the colon and rectum.

[13]  D. Fan,et al.  Preoperative infliximab use and postoperative complications in Crohn's disease: a systematic review and meta-analysis. , 2014, International journal of surgery.

[14]  B. Bressler,et al.  The risks of post-operative complications following pre-operative infliximab therapy for Crohn's disease in patients undergoing abdominal surgery: a systematic review and meta-analysis. , 2013, Journal of Crohn's & colitis.

[15]  A. Ford,et al.  Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis. , 2013, Journal of Crohn's & colitis.

[16]  J. Marshall,et al.  Meta‐analysis: peri‐operative anti‐TNFα treatment and post‐operative complications in patients with inflammatory bowel disease , 2013, Alimentary pharmacology & therapeutics.

[17]  Zhiping Yang,et al.  Meta‐analysis: effect of preoperative infliximab use on early postoperative complications in patients with ulcerative colitis undergoing abdominal surgery , 2012, Alimentary pharmacology & therapeutics.

[18]  P. Rutgeerts,et al.  Corticosteroids but not infliximab increase short‐term postoperative infectious complications in patients with ulcerative colitis , 2009, Inflammatory bowel diseases.