Activity of Some Plant Extracts of Some Plant Extracts Some Plant Extracts Plant Extracts Against Multi-Drug Resistant Human Pathogens -Drug Resistant Human Pathogens

Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Hence, antibacterial activities of ethanolic extracts of 19 plant species were studied against multi-drug resistant clinical isolates using agar well diffusion method. Extracts of Extracts of of Liquidambar orientalis, Vitis vinifera,�5RVPDULQXVRIoFLQDOLV , Punica granatum, Cornus sanguinea, Euphorbia peplus, Ecballium elaterium, Inula viscosa and Liquidambar orientalis showed broad-spectrum antibacterial activity with inhibition zones ranging from 8 to 26 mm. The most resistant organisms were Escherichia coli (E. coli) (Ampicillin-, amoxycillin- and sulfamethoxazole-resistant), Stenotrophomonas maltophilia (S. maltophilia) (Amoxycillin- and nalidixic acid-resistant) and Klebsiella pneumoniae (K. pneumoniae) (Ampicillin-, amoxycillin- and aztreonam-resistant), and the most susceptible species were Staphylococcus aureus (S. aureus) (Penicillin G- and oxacillin-resistant), Streptococcus pyogenes (S. pyogenes) (Penicillin G-, erythromycin- and clindamycin-resistant) and Pseudomonas aeruginosa (P. aeruginosa) (Sulfamethoxazole- and novobiocin-resistant), respectively. Minimum Inhibitory Concentrations (MIC) of crude extracts were determined for the seven highly active plants showing activity against methicillin resistant S. aureus (MRSA), E. coli, P. aeruginosa, S. pneumoniae and the reference bacteria (E. coli ATCC 11229 and Kocuria rhizophila ATCC 9341 NA). MICs of active extracts ranged from 8 to 14.2 mg/mL against one or other test bacteria.

[1]  M. Oskay,et al.  Antimicrobial Screening of Some Turkish Medicinal Plants , 2007 .

[2]  E. Oktayoglu,et al.  Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. , 2004, Journal of ethnopharmacology.

[3]  B. Dulger,et al.  ANTIMICROBIAL ACTIVITY OF CERTAIN PLANTS USED IN TURKISH TRADITIONAL MEDICINE , 2004 .

[4]  F. Jahaniani,et al.  Evaluation of Antibacterial Activity of Tribulus terrestris L. Growing in Iran , 2003 .

[5]  Ö. Erdoğrul,et al.  Antimicrobial Activities of Various Medicinal and Commercial Plant Extracts , 2003 .

[6]  Ö. Erdoğrul.  Antibacterial Activities of Some Plant Extracts Used in Folk Medicine , 2002 .

[7]  S. Karaman,et al.  Traditional Medicinal Plants of K. Maras (Turkey) , 2001 .

[8]  I. Ahmad,et al.  Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. , 2001, Journal of ethnopharmacology.

[9]  P. Huovinen,et al.  A between-Species Comparison of Antimicrobial Resistance in Enterobacteria in Fecal Flora , 2000, Antimicrobial Agents and Chemotherapy.

[10]  A. Alkofahi,et al.  Antibacterial Activity of Jordanian Medicinal Plants , 1999 .

[11]  Ronald N. Jones,et al.  Bacterial Pathogens Isolated from Patients with Bloodstream Infection: Frequencies of Occurrence and Antimicrobial Susceptibility Patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997) , 1998, Antimicrobial Agents and Chemotherapy.

[12]  B. Şener,et al.  Biological activities of some Turkish medicinal plants , 1998 .

[13]  J. Eloff.  Which extractant should be used for the screening and isolation of antimicrobial components from plants? , 1998, Journal of ethnopharmacology.

[14]  F. Soriano,et al.  Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents , 1995, Antimicrobial agents and chemotherapy.

[15]  C. Rodriguez,et al.  An antibiotic assay by the agar well diffusion method , 1990 .

[16]  A. Bauer,et al.  Antibiotic susceptibility testing by a standardized single disk method. , 1966, American journal of clinical pathology.