AMap of HumanMitochond rial Protein Interactions Linked toNeurodegenerationRevealsNewMechanisms of Redox Homeostasis and NFk B Signaling Graphical

[1]  Devin K. Schweppe,et al.  Architecture of the human interactome defines protein communities and disease networks , 2017, Nature.

[2]  Nichollas E. Scott,et al.  Interactome disassembly during apoptosis occurs independent of caspase cleavage , 2017, Molecular Systems Biology.

[3]  T. Luedde,et al.  Negative regulation of NF-κB p65 activity by serine 536 phosphorylation , 2016, Science Signaling.

[4]  Robert W. Taylor,et al.  Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. , 2016, Molecular cell.

[5]  Zhihai Ma,et al.  Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders. , 2015, Cell systems.

[6]  James Y. Zou.  Analysis of protein-coding genetic variation in 60,706 humans , 2015, Nature.

[7]  Marco Y. Hein,et al.  A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances , 2015, Cell.

[8]  Karl R. Clauser,et al.  MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins , 2015, Nucleic Acids Res..

[9]  Greg W. Clark,et al.  Panorama of ancient metazoan macromolecular complexes , 2015, Nature.

[10]  Kali T. Witherspoon,et al.  Excess of rare, inherited truncating mutations in autism , 2015, Nature Genetics.

[11]  Daniele Ghezzi,et al.  Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts , 2015, Front. Genet..

[12]  A. Kanda,et al.  ATP6AP2/(Pro)renin Receptor Contributes to Glucose Metabolism via Stabilizing the Pyruvate Dehydrogenase E1 β Subunit* , 2015, The Journal of Biological Chemistry.

[13]  R. Youle,et al.  The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease , 2015, Neuron.

[14]  James Vlasblom,et al.  Mitochondrial Targets for Pharmacological Intervention in Human Disease , 2014, Journal of proteome research.

[15]  Barbara Corneo,et al.  CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral Cortex Development from Human Embryonic Stem Cells , 2014, Neuron.

[16]  V. Perry,et al.  Microglial priming in neurodegenerative disease , 2014, Nature Reviews Neurology.

[17]  B. Garcia,et al.  Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. , 2014, Molecular cell.

[18]  S. Horvath,et al.  Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism , 2013, Cell.

[19]  D. Stephenson,et al.  Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action , 2013, Molecular Autism.

[20]  F. Gao,et al.  Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway , 2013, PloS one.

[21]  A. Burlingame,et al.  A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1 , 2013, Cell.

[22]  E. Fisher,et al.  Is SOD1 loss of function involved in amyotrophic lateral sclerosis? , 2013, Brain : a journal of neurology.

[23]  M. Hengstschläger,et al.  Merging high-quality biochemical fractionation with a refined flow cytometry approach to monitor nucleocytoplasmic protein expression throughout the unperturbed mammalian cell cycle , 2013, Nature Protocols.

[24]  Franco J. Vizeacoumar,et al.  Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae , 2012, Nature.

[25]  Andrei L. Turinsky,et al.  A Census of Human Soluble Protein Complexes , 2012, Cell.

[26]  C. von Mering,et al.  PaxDb, a Database of Protein Abundance Averages Across All Three Domains of Life , 2012, Molecular & Cellular Proteomics.

[27]  A. Nesvizhskii,et al.  Comparative analysis of different label-free mass spectrometry based protein abundance estimates and their correlation with RNA-Seq gene expression data. , 2012, Journal of proteome research.

[28]  Haiyuan Yu,et al.  Detecting overlapping protein complexes in protein-protein interaction networks , 2012, Nature Methods.

[29]  J. Nunnari,et al.  Mitochondria: In Sickness and in Health , 2012, Cell.

[30]  N. Hattori,et al.  PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria , 2012, Nature Communications.

[31]  F. Khuri,et al.  Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. , 2011, Molecular cell.

[32]  D. Rossignol,et al.  Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis , 2011, Molecular Psychiatry.

[33]  David S. Park,et al.  Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. , 2010, Human molecular genetics.

[34]  N. Bonini,et al.  DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function , 2010, Proceedings of the National Academy of Sciences.

[35]  T. Gasser,et al.  DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. , 2009, Free radical biology & medicine.

[36]  Peter J. Keller,et al.  SUMOylation of the mitochondrial fission protein Drpl occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  C. Kaltschmidt,et al.  NF-kappaB in the nervous system. , 2009, Cold Spring Harbor perspectives in biology.

[38]  Siu-Ming Yiu,et al.  Predicting Protein Complexes from PPI Data: A Core-Attachment Approach , 2009, J. Comput. Biol..

[39]  S. Carr,et al.  A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology , 2008, Cell.

[40]  Toshihiko Oka,et al.  Mitotic Phosphorylation of Dynamin-related GTPase Drp1 Participates in Mitochondrial Fission* , 2007, Journal of Biological Chemistry.

[41]  Yuan-Ping Pang,et al.  Cryptic proteolytic activity of dihydrolipoamide dehydrogenase , 2007, Proceedings of the National Academy of Sciences.

[42]  P. Shaw,et al.  Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. , 2006, Biochimica et biophysica acta.

[43]  I. Roman,et al.  In vitro interactions between the two mitochondrial membrane proteins VDAC and cytochrome c oxidase. , 2005, Biochemistry.

[44]  M. Schwartz,et al.  The retina as a window to the brain—from eye research to CNS disorders , 2013, Nature Reviews Neurology.

[45]  J. Glass,et al.  SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. , 2011, Brain : a journal of neurology.

[46]  N. Gulbahce,et al.  Network medicine: a network-based approach to human disease , 2010, Nature Reviews Genetics.