Global aromaticity in 3D π-conjugated molecular cages remains largely unexplored. Herein, we report the facile synthesis of a fully conjugated molecular cage ( 1 ) containing two bridged triphenylamine units and three quinoidal bithiophene arms. X-ray crystallographic analysis, NMR/ESR measurements and theoretical calculations reveal that: ( 1 ) its dication ( 1 2+ ) has an open-shell singlet ground state and is 3D globally aromatic, with individual macrocycles being 2D Hückel aromatic; (2) its tetracation ( 1 4+ ) has a triplet ground state and is also 3D globally aromatic, with individual macrocycles being 2D Baird aromatic; and (3) its hexacation ( 1 6+ ) has a closed-shell nature and shows local aromaticity. The study revealed a close relationship between 2D Hückel/Baird aromaticity and 3D global π-aromaticity.