An immunocompetent rectal cancer model to study radiation therapy

[1]  F. Buettner,et al.  Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. , 2022, Cancer cell.

[2]  Pengfei Xu,et al.  Global colorectal cancer burden in 2020 and projections to 2040 , 2021, Translational oncology.

[3]  A. Durán,et al.  Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum , 2021, STAR protocols.

[4]  A. Jemal,et al.  Cancer Statistics, 2021 , 2021, CA: a cancer journal for clinicians.

[5]  I. Fichtner,et al.  Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine , 2020, Neoplasia.

[6]  T. Ashizawa,et al.  Effect of preoperative chemoradiotherapy on the immunological status of rectal cancer patients , 2020, Journal of radiation research.

[7]  P. Buckhaults,et al.  Early-onset colorectal cancer: initial clues and current views , 2020, Nature Reviews Gastroenterology & Hepatology.

[8]  E. Hau,et al.  Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer , 2020, Frontiers in Cell and Developmental Biology.

[9]  Jessica A Lavery,et al.  A rectal cancer organoid platform to study individual responses to chemoradiation , 2019, Nature Medicine.

[10]  S. Lowe,et al.  Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome , 2019, Proceedings of the National Academy of Sciences.

[11]  M. Leclerc,et al.  Mucosal healing progression after acute colitis in mice , 2019, World journal of gastroenterology.

[12]  E. Giovannucci,et al.  Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies , 2019, Nature Reviews Gastroenterology & Hepatology.

[13]  J. Ferlay,et al.  Changes in colorectal cancer incidence in seven high-income countries: a population-based study. , 2019, The lancet. Gastroenterology & hepatology.

[14]  S. Carter,et al.  Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer , 2019, Clinical Cancer Research.

[15]  Jeffrey S. Morris,et al.  Clinical and molecular characterization of early‐onset colorectal cancer , 2019, Cancer.

[16]  V. Zadnik,et al.  Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years , 2019, Gut.

[17]  I. Melero,et al.  TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies , 2019, Molecular Cancer Therapeutics.

[18]  S. Ellsworth.  Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors , 2018, Advances in radiation oncology.

[19]  D. Margolin,et al.  An Optimal Orthotopic Mouse Model for Human Colorectal Cancer Primary Tumor Growth and Spontaneous Metastasis , 2018, Diseases of the colon and rectum.

[20]  Y. Baskın,et al.  Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature , 2018, Gastroenterology research.

[21]  H. Begthel,et al.  A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression , 2018, Nature Protocols.

[22]  Adam Akkad,et al.  Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation , 2018, Nature Protocols.

[23]  Philip S Rosenberg,et al.  Colorectal Cancer Incidence Patterns in the United States, 1974–2013 , 2017, Journal of the National Cancer Institute.

[24]  Teng Han,et al.  Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer , 2017, Nature Biotechnology.

[25]  Francisco J. Sánchez-Rivera,et al.  In vivo genome editing and organoid transplantation models of colorectal cancer , 2017, Nature Biotechnology.

[26]  Zachary J. Heins,et al.  Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. , 2016, Gastroenterology.

[27]  C. Poremba,et al.  Endoscopy-guided orthotopic implantation of colorectal cancer cells results in metastatic colorectal cancer in mice , 2016, Clinical & Experimental Metastasis.

[28]  M. Uchihashi,et al.  Surgical Correction of Rectal Prolapse in Laboratory Mice (Mus musculus). , 2015, Journal of the American Association for Laboratory Animal Science : JAALAS.

[29]  Hans Clevers,et al.  Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer , 2015, Cell.

[30]  Hans Clevers,et al.  Sequential cancer mutations in cultured human intestinal stem cells , 2015, Nature.

[31]  M. Gönen,et al.  Comparison of tumor regression grade systems for locally advanced rectal cancer after multimodality treatment. , 2014, Journal of the National Cancer Institute.

[32]  B. Chassaing,et al.  Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice , 2014, Current protocols in immunology.

[33]  M. Bouvet,et al.  Development of a Clinically-Precise Mouse Model of Rectal Cancer , 2013, PloS one.

[34]  K. Schäkel,et al.  Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. , 2013, Cancer cell.

[35]  W. Oyen,et al.  Quantitative Immuno-SPECT Monitoring of Pretargeted Radioimmunotherapy with a Bispecific Antibody in an Intraperitoneal Nude Mouse Model of Human Colon Cancer , 2012, The Journal of Nuclear Medicine.

[36]  S. Ichinose,et al.  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell , 2012, Nature Medicine.

[37]  P. Snyder,et al.  Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine , 2010, Molecular Cancer Research.

[38]  Umar Mahmood,et al.  Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment , 2010, Proceedings of the National Academy of Sciences.

[39]  K. Zatloukal,et al.  In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[40]  Laurence Zitvogel,et al.  Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy , 2007, Nature Medicine.

[41]  Markus F Neurath,et al.  An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression , 2007, Nature Protocols.

[42]  D. Treanor,et al.  Pathological response following long‐course neoadjuvant chemoradiotherapy for locally advanced rectal cancer , 2005, Histopathology.

[43]  K. Nomoto,et al.  A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells , 2004, Cancer science.

[44]  Takuji Tanaka,et al.  A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate , 2003, Cancer science.

[45]  J. Coxhead,et al.  Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[46]  N. Ikekawa,et al.  Inhibition of HT-29 human colon cancer growth under the renal capsule of severe combined immunodeficient mice by an analogue of 1,25-dihydroxyvitamin D3, DD-003. , 1994, Cancer research.

[47]  油井 史郎.  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell , 2011 .