Numerical analysis of a gas bubble near bio-materials in an ultrasound field.

Ultrasonic cavitation bubble phenomena play a key role in numerous medical procedures such as ultrasound-assisted lipoplasty, phacoemulsification, lithotripsy, brain tumor surgery, muscle and bone therapies and intraocular or transdermal drug delivery. This study investigates numerically the interaction of a bubble with a bio-material (fat, skin, cornea, brain, muscle, cartilage or bone) involved in the treatments mentioned when subjected to an ultrasound field. A range of frequencies is used to study the bubble behavior in terms of its growth and collapse shapes, and the maximum jet velocity attained. Simulation results show complex dynamic behaviors of the bubble. In several cases a jet is formed directed away from the bio-material while in others, toward it. In certain cases, the bubble eventually breaks into two, with or without the formation of opposite penetrating jets. Very high maximum velocities of jets directing away or toward the bio-materials can be observed in some cases (700 to 900 ms(-1)).

[1]  J P Clarys,et al.  Adipose tissue density, estimated adipose lipid fraction and whole body adiposity in male cadavers. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[2]  A. Prosperetti,et al.  Bubble Dynamics and Cavitation , 1977 .

[3]  A F Mak,et al.  Objective assessment of limb tissue elasticity: development of a manual indentation procedure. , 1999, Journal of rehabilitation research and development.

[4]  J. Chapelon,et al.  Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles , 2000, The Journal of the Acoustical Society of America.

[5]  Richard S. Snell,et al.  Clinical Anatomy of the Eye , 1990 .

[6]  G. Trahey,et al.  Shear-wave generation using acoustic radiation force: in vivo and ex vivo results. , 2003, Ultrasound in medicine & biology.

[7]  L. R. Duarte.  The stimulation of bone growth by ultrasound , 2004, Archives of orthopaedic and traumatic surgery.

[8]  L A Crum,et al.  Use of a dual-pulse lithotripter to generate a localized and intensified cavitation field. , 2001, The Journal of the Acoustical Society of America.

[9]  T. Leighton.  The Acoustic Bubble , 1994 .

[10]  E. Turiel.  The Development of Morality , 2007 .

[11]  P. Zhong,et al.  Suppression of large intraluminal bubble expansion in shock wave lithotripsy without compromising stone comminution: methodology and in vitro experiments. , 2001, The Journal of the Acoustical Society of America.

[12]  Tetsuya Kodama,et al.  Cavitation bubble behavior and bubble–shock wave interaction near a gelatin surface as a study of in vivo bubble dynamics , 2000 .

[13]  M. Brock,et al.  Ultrasonic aspiration in neurosurgery , 2005, Neurosurgical Review.

[14]  Teppo L N Järvinen,et al.  Muscle Injuries , 2005, The American journal of sports medicine.

[15]  G. Maddern,et al.  Ultrasound‐assisted lipoplasty , 2001, ANZ journal of surgery.

[16]  K. C. Hung,et al.  Simulations of pressure pulse–bubble interaction using boundary element method , 2006 .

[17]  Christopher E. Brennen,et al.  Fundamentals of Multiphase Flow , 2005 .

[18]  John R. Blake,et al.  Cavitation Bubbles Near Boundaries , 1987 .

[19]  G Kossoff,et al.  Heating of guinea-pig fetal brain during exposure to pulsed ultrasound. , 1993, Ultrasound in medicine & biology.

[20]  Emil-Alexandru Brujan,et al.  The role of cavitation microjets in the therapeutic applications of ultrasound. , 2004, Ultrasound in medicine & biology.

[21]  Kester Nahen,et al.  Dynamics of laser-induced cavitation bubbles near an elastic boundary , 2001, Journal of Fluid Mechanics.

[22]  E. Kimmel,et al.  Gas bubble pulsation in a semiconfined space subjected to ultrasound. , 2001, The Journal of the Acoustical Society of America.

[23]  R. Langer,et al.  Biomaterials in drug delivery and tissue engineering: one laboratory's experience. , 2000, Accounts of chemical research.

[24]  Evert Klaseboer,et al.  An oscillating bubble near an elastic material , 2004 .

[25]  L A Crum,et al.  Acoustic cavitation generated by an extracorporeal shockwave lithotripter. , 1987, Ultrasound in medicine & biology.

[26]  K. M. Patil,et al.  Analysis of stresses in two-dimensional models of normal and neuropathic feet , 2006, Medical and Biological Engineering and Computing.

[27]  Qian Wang,et al.  Nonlinear interaction between gas bubble and free surface , 1996 .

[28]  M. Minnaert.  XVI.On musical air-bubbles and the sounds of running water , 1933 .

[29]  Evert Klaseboer,et al.  A collapsing bubble-induced micro-pump using the jetting effect , 2005 .

[30]  John I. Clark,et al.  Drug Delivery Into the Eye With the Use of Ultrasound , 2004, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[31]  Evert Klaseboer,et al.  Boundary integral equations as applied to an oscillating bubble near a fluid-fluid interface , 2004 .

[32]  Claude Tarriere,et al.  Development of a F.E.M. of the human head according to a specific test protocol , 1992 .

[33]  Alan M. Wilson,et al.  The role of the extrinsic thoracic limb muscles in equine locomotion , 2004, Journal of anatomy.

[34]  Ann B. Ehrlich,et al.  Medical Terminology for Health Professions , 1988 .

[35]  Kester Nahen,et al.  Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus , 2001, Journal of Fluid Mechanics.

[36]  A. Borthakur,et al.  Water distribution patterns inside bovine articular cartilage as visualized by 1H magnetic resonance imaging. , 2001, Osteoarthritis and cartilage.

[37]  M. Barda-Saad,et al.  Apoptosis induction of human myeloid leukemic cells by ultrasound exposure. , 2000, Cancer research.

[38]  L. Crum,et al.  Physical mechanisms of the therapeutic effect of ultrasound (a review) , 2003 .

[39]  M. Minnarert,et al.  Musical air-bubbles and the sound of running water , 1933 .

[40]  Yukio Tomita,et al.  Numerical analysis of a gas bubble near a rigid boundary in an oscillatory pressure field , 1994 .

[41]  J. Mclean.  Atlas of cataract surgery , 1965 .