Physical Activity and Bone Health

SUMMARY Weight-bearing physical activity has beneficial effects on bone health across the age spectrum. Physical activities that generate relatively high-intensity loading forces, such as plyometrics, gymnastics, and high-inten- sity resistance training, augment bone mineral accrual in children and adolescents. Further, there is some evidence that exercise-induced gains in bone mass in children are maintained into adulthood, suggesting that physical activity habits during childhood may have long-lasting benefits on bone health. It is not yet possible to describe in detail an exercise program for children and adolescents that will optimize peak bone mass, because quantitative dose-response studies are lacking. However, evidence from multiple small randomized, controlled trials suggests that the following exercise prescription will augment bone mineral accrual in children and adolescents: lacking During adulthood, the primary goal of physical activity should be to maintain bone mass. Whether adults can increase bone mineral density (BMD) through exercise training remains equivocal. When increases have been reported, it has been in response to relatively high intensity weight-bearing endurance or resistance exercise; gains in BMD do not appear to be preserved when the exercise is discontinued. Observational studies suggest that the age-related decline in BMD is attenuated, to preserve skeletal integrity. Exercise programs for elderly women and men should include not only weight-bearing endurance and resistance activities aimed at preserving bone mass, but also activities designed to improve balance and prevent falls. Maintaining a vigorous level of physical activity across the lifespan should be viewed as an essential component of the prescription for achieving and maintaining good bone health.

[1]  C. Snow,et al.  Effects of plyometric jump training on bone mass in adolescent girls. , 2000, Medicine and science in sports and exercise.

[2]  P. Kannus,et al.  Changes in bone mineral content with decreased training in competitive young adult tennis players and controls: a prospective 4-yr follow-up. , 1999, Medicine and science in sports and exercise.

[3]  B. Hurley,et al.  Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. , 1993, Journal of applied physiology.

[4]  C. Mulrow,et al.  A randomized trial of physical rehabilitation for very frail nursing home residents. , 1994, JAMA.

[5]  C. Snow,et al.  Detraining Reverses Positive Effects of Exercise on the Musculoskeletal System in Premenopausal Women , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[6]  Claus Christiansen,et al.  Diagnosis of Osteoporosis , 1992, Southern medical journal.

[7]  S. Gordon,et al.  Effect of resistance exercise training on cortical and cancellous bone in mature male rats. , 1998, Journal of applied physiology.

[8]  D B Burr,et al.  Physical activity and bone mass: exercises in futility? , 1993, Bone and mineral.

[9]  L. Pruitt,et al.  Weight‐training effects on bone mineral density in early postmenopausal women , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[10]  P. Shekelle,et al.  Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials , 2004, BMJ : British Medical Journal.

[11]  A. Campbell,et al.  Exercise in preventing falls and fall related injuries in older people: a review of randomised controlled trials , 2000, British journal of sports medicine.

[12]  L. Lanyon,et al.  Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[13]  W. Kohrt,et al.  HRT preserves increases in bone mineral density and reductions in body fat after a supervised exercise program. , 1998, Journal of applied physiology.

[14]  J. Aloia,et al.  Effect of treadmill exercise on vertebral and tibial bone mineral content and bone mineral density in the aged adult rat: Determined by dual energy X-ray absorptiometry , 1993, Calcified Tissue International.

[15]  G. McCabe,et al.  Impact of exercise on bone health and contraindication of oral contraceptive use in young women. , 2001, Medicine and science in sports and exercise.

[16]  A. Pfefferbaum,et al.  Age-related loss of trabecular bone in premenopausal women: A biopsy study , 1983, Calcified Tissue International.

[17]  B. Specker,et al.  Bone mineral density in elite 7- to 9-yr-old female gymnasts and swimmers. , 1996, Medicine and science in sports and exercise.

[18]  H. Genant,et al.  Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial. , 2003, Bone.

[19]  E. Orwoll Toward an Expanded Understanding of the Role of the Periosteum in Skeletal Health , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  J. Shaw,et al.  Swim-trained rats have greater bone mass, density, strength, and dynamics. , 2001, Journal of applied physiology.

[21]  M. Tinetti,et al.  The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and Injuries: Cooperative Studies of Intervention Techniques. , 1995, JAMA.

[22]  J. Mulcare,et al.  ENERGY EXPENDITURE OF WALKING IN PERSONS WITH MULTIPLE SCLEROSIS USING THE TRI-TRAC ACCELEROMETER , 2001 .

[23]  K M Khan,et al.  Augmented trochanteric bone mineral density after modified physical education classes: a randomized school-based exercise intervention study in prepubescent and early pubescent children. , 2000, The Journal of pediatrics.

[24]  J. Aloia,et al.  To what extent is bone mass determined by fat-free or fat mass? , 1995, The American journal of clinical nutrition.

[25]  C. Sanborn,et al.  Resistance training and bone mineral density in adolescent females. , 2001, The Journal of pediatrics.

[26]  D. Williams,et al.  Bone Gains and Losses Follow Seasonal Training and Detraining in Gymnasts , 2001, Calcified Tissue International.

[27]  A. Hicks,et al.  Long-term resistance training in the elderly: effects on dynamic strength, exercise capacity, muscle, and bone. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  D. Bailey,et al.  The Saskatchewan Pediatric Bone Mineral Accrual Study: Bone Mineral Acquisition During the Growing Years , 1997, International journal of sports medicine.

[29]  A. Heinonen,et al.  Effects of unilateral strength training and detraining on bone mineral density and content in young women: A study of mechanical loading and deloading on human bones , 1994, Calcified Tissue International.

[30]  J L McNitt-Gray,et al.  Kinetics of the lower extremities during drop landings from three heights. , 1993, Journal of biomechanics.

[31]  J. Shaw,et al.  Long-term exercise using weighted vests prevents hip bone loss in postmenopausal women. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[32]  Heather A McKay,et al.  A school-based exercise intervention elicits substantial bone health benefits: a 2-year randomized controlled trial in girls. , 2003, Pediatrics.

[33]  J. Chow Role of Nitric Oxide and Prostaglandins in the Bone Formation Response to Mechanical Loading , 2000, Exercise and sport sciences reviews.

[34]  W. Willett,et al.  Walking and leisure-time activity and risk of hip fracture in postmenopausal women. , 2002, JAMA.

[35]  C Ronald MacKenzie,et al.  Hip fractures among the elderly: causes, consequences and control , 2003, Ageing Research Reviews.

[36]  A. Manley Physical Activity And Health: A Report Of The Surgeon General , 2004 .

[37]  W C Hayes,et al.  Age-related reductions in the strength of the femur tested in a fall-loading configuration. , 1995, The Journal of bone and joint surgery. American volume.

[38]  Philippa Williams,et al.  The Effect of a 12‐Month Exercise Trial on Balance, Strength, and Falls in Older Women: A Randomized Controlled Trial , 1995, Journal of the American Geriatrics Society.

[39]  J. Aloia,et al.  Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat. , 1999, Bone.

[40]  Alan D. Martin,et al.  Calcium Accretion in Girls and Boys During Puberty: A Longitudinal Analysis , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  J. Harrison,et al.  Effect of two randomised exercise programmes on bone mass of healthy postmenopausal women. , 1987, British medical journal.

[42]  J. Kaprio,et al.  Physical activity and osteoporotic hip fracture risk in men. , 2000, Archives of internal medicine.

[43]  J. Heikkinen,et al.  HRT and exercise: effects on bone density, muscle strength and lipid metabolism. A placebo controlled 2-year prospective trial on two estrogen-progestin regimens in healthy postmenopausal women. , 1997, Maturitas.

[44]  C. Modlesky,et al.  Nutrition, Physical Activity and Bone Health in Women , 1994, Nutrition Research Reviews.

[45]  S. Palle,et al.  Adverse effects of strenuous exercise: a densitometric and histomorphometric study in the rat. , 1994, Journal of applied physiology.

[46]  K. Jepsen,et al.  Understanding bone strength: size isn't everything. , 2001, Bone.

[47]  E. Protas,et al.  Effects of weight lifting on bone mineral density in premenopausal women , 1990 .

[48]  G A Naughton,et al.  Prospective Ten‐Month Exercise Intervention in Premenarcheal Girls: Positive Effects on Bone and Lean Mass , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[49]  E. Bassey,et al.  Pre‐ and Postmenopausal Women Have Different Bone Mineral Density Responses to the Same High‐Impact Exercise , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  Alexander G Robling,et al.  Designing Exercise Regimens to Increase Bone Strength , 2003, Exercise and sport sciences reviews.

[51]  Michael A. Parfitt,et al.  Which Stereological Methods Offer the Greatest Help in Quantifying Trabecular Structure from Biological and Mechanical Perspectives , 1998 .

[52]  R. Cumming,et al.  Interventions for preventing falls in elderly people. , 2003, The Cochrane database of systematic reviews.

[53]  A Heinonen,et al.  Effect of Long‐Term Unilateral Activity on Bone Mineral Density of Female Junior Tennis Players , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[54]  C. Modlesky,et al.  A prospective study of bone mass and body composition in female adolescent gymnasts. , 2002, The Journal of pediatrics.

[55]  S L Hui,et al.  Role of physical activity in the development of skeletal mass in children , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[56]  A. Heinonen,et al.  High-Impact Exercise and Bones of Growing Girls: A 9-Month Controlled Trial , 2000, Osteoporosis International.

[57]  R. Rizzoli,et al.  A prospective study on socioeconomic aspects of fracture of the proximal femur , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[58]  T. Notomi,et al.  Effects of Tower Climbing Exercise on Bone Mass, Strength, and Turnover in Growing Rats , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  L. Lanyon,et al.  Mechanical strain activates estrogen response elements in bone cells. , 2000, Bone.

[60]  A. Parfitt,et al.  Bone remodeling. , 1988, Henry Ford Hospital medical journal.

[61]  L. Houtkooper,et al.  Effects of Exercise Training on Bone Remodeling, Insulin-Like Growth Factors, and Bone Mineral Density in Postmenopausal Women With and Without Hormone Replacement Therapy , 2003, Calcified Tissue International.

[62]  D R Carter,et al.  Effects of resistance and endurance exercise on bone mineral status of young women: A randomized exercise intervention trial , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[63]  C. F. Sharp,et al.  Effect of long‐distance running on bone mass in women , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[64]  S. Powers,et al.  Effects of running on the torsional strength, morphometry, and bone mass of the rat skeleton. , 1995, Medicine and science in sports and exercise.

[65]  D B Burr,et al.  Bone, exercise, and stress fractures. , 1997, Exercise and sport sciences reviews.

[66]  C. Turner,et al.  Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation , 1998, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[67]  R. Zernicke,et al.  High-impact exercise and growing bone: relation between high strain rates and enhanced bone formation. , 2000, Journal of applied physiology.

[68]  Mark A Pereira,et al.  Physical Activity, Falls, and Fractures Among Older Adults: A Review of the Epidemiologic Evidence , 2000, Journal of the American Geriatrics Society.

[69]  C C Glüer,et al.  A two‐year program of aerobics and weight training enhances bone mineral density of young women , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[70]  D. J. Cavanaugh,et al.  Brisk walking does not stop bone loss in postmenopausal women. , 1988, Bone.

[71]  Toshitaka Nakamura,et al.  A comparison of resistance and aerobic training for mass, strength and turnover of bone in growing rats , 2000, European Journal of Applied Physiology.

[72]  P. Kannus,et al.  Randomized Controlled Study of Effects of Sudden Impact Loading on Rat Femur , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[73]  Y. Umemura,et al.  Five Jumps per Day Increase Bone Mass and Breaking Force in Rats , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[74]  E. Bergstralh,et al.  Three-year controlled, randomized trial of the effect of dose-specified loading and strengthening exercises on bone mineral density of spine and femur in nonathletic, physically active women. , 1996, Bone.

[75]  W. Kohrt,et al.  Effects of Exercise Involving Predominantly Either Joint‐Reaction or Ground‐Reaction Forces on Bone Mineral Density in Older Women , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[76]  O. Johnell,et al.  World-wide Projections for Hip Fracture , 1997, Osteoporosis International.

[77]  M. Fiatarone,et al.  Effects of High-Intensity Strength Training on Multiple Risk Factors for Osteoporotic Fractures: A Randomized Controlled Trial , 1994 .

[78]  J. Cauley,et al.  Physical activity and osteoporotic fracture risk in older women. Study of Osteoporotic Fractures Research Group. , 1998, Annals of internal medicine.

[79]  K.,et al.  Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. , 1981, The Journal of clinical investigation.

[80]  Matthew J. Silva,et al.  The Effects of Repetitive Physiologic Loading on Bone Turnover and Mechanical Properties in Adult Female and Male Rats , 2001, Calcified Tissue International.

[81]  K. Yarasheski,et al.  Effect of resistance exercise and growth hormone on bone density in older men , 1997, Clinical endocrinology.

[82]  R. Wiswell,et al.  The inability of hormone replacement therapy or chronic running to maintain bone mass in master athletes. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[83]  A. Ehsani,et al.  Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women. , 1988, Annals of internal medicine.

[84]  A. S. Ryan,et al.  Loss of Bone Mineral Density in Women Athletes During Aging , 1998, Calcified Tissue International.

[85]  D. Levy,et al.  Effects of resistance training on bone mineral content and density in adolescent females. , 1996, Canadian journal of physiology and pharmacology.

[86]  Cho Jw,et al.  Role of Nitric Oxide and Prostaglandins in the Bone Formation Response to Mechanical Loading , 2000, Exercise and sport sciences reviews.

[87]  G E Dallal,et al.  A 1-y walking program and increased dietary calcium in postmenopausal women: effects on bone. , 1991, The American journal of clinical nutrition.

[88]  D. Kerr,et al.  Resistance Training over 2 Years Increases Bone Mass in Calcium‐Replete Postmenopausal Women , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[89]  M. Peterson,et al.  Muscular strength and bone density with weight training in middle-aged women. , 1991, Medicine and science in sports and exercise.

[90]  S. J. Ramsdale,et al.  Increase in femoral bone density in young women following high-impact exercise , 1994, Osteoporosis International.

[91]  L. Lanyon,et al.  Regulation of bone formation by applied dynamic loads. , 1984, The Journal of bone and joint surgery. American volume.

[92]  M. Schroll,et al.  Leisure-time physical activity levels and changes in relation to risk of hip fracture in men and women. , 2001, American journal of epidemiology.

[93]  A. Heinonen,et al.  A Randomized School‐Based Jumping Intervention Confers Site and Maturity‐Specific Benefits on Bone Structural Properties in Girls: A Hip Structural Analysis Study , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[94]  J. Fries,et al.  Impact of running on lumbar bone density: a 5-year longitudinal study. , 1992, The Journal of rheumatology.

[95]  K M Khan,et al.  Bone Mineral Response to a 7‐Month Randomized Controlled, School‐Based Jumping Intervention in 121 Prepubertal Boys: Associations With Ethnicity and Body Mass Index , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[96]  J. Kanis Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , 1994 .

[97]  M. Pollock,et al.  Resistance exercise training restores bone mineral density in heart transplant recipients. , 1996, Journal of the American College of Cardiology.

[98]  C Probart,et al.  Estrogen therapy and variable-resistance weight training increase bone mineral in surgically menopausal women. , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[99]  Z. Tran,et al.  Exercise and bone mineral density in men: a meta-analysis. , 2000, Journal of applied physiology.

[100]  Lora Giangregorio,et al.  Skeletal Adaptations to Alterations in Weight-Bearing Activity , 2002, Sports medicine.

[101]  Ari Heinonen,et al.  Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures , 1996, The Lancet.

[102]  R. Prince,et al.  Exercise effects on bone mass in postmenopausal women are site‐specific and load‐dependent , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[103]  P. Wingo,et al.  Physical activity, functional limitations, and the risk of fall-related fractures in community-dwelling elderly. , 1997, Annals of epidemiology.

[104]  S. Blair,et al.  A one-year follow-up to physical activity and health. A report of the Surgeon General. , 1999, American journal of preventive medicine.

[105]  D. Baran,et al.  Weight training decreases vertebral bone density in premenopausal women: a prospective study. , 1990, The Journal of clinical endocrinology and metabolism.

[106]  Jill L. McNitt-Gray,et al.  The momentum generated by segments during drop landings , 1993 .

[107]  D. Burr,et al.  Effects of biomechanical stress on bones in animals. , 2002, Bone.

[108]  I. Owan,et al.  Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo. , 1996, The American journal of physiology.

[109]  Scott B Going,et al.  Weight lifted in strength training predicts bone change in postmenopausal women. , 2003, Medicine and science in sports and exercise.

[110]  E Itoi,et al.  Stronger back muscles reduce the incidence of vertebral fractures: a prospective 10 year follow-up of postmenopausal women. , 2002, Bone.

[111]  M. Mcdermott,et al.  The effects of region-specific resistance and aerobic exercises on bone mineral density in premenopausal women. , 2001, Military medicine.

[112]  J. J. Bauer,et al.  Jumping Improves Hip and Lumbar Spine Bone Mass in Prepubescent Children: A Randomized Controlled Trial , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[113]  Z. Tran,et al.  Resistance Training and Bone Mineral Density in Women: A Meta-Analysis of Controlled Trials , 2001, American journal of physical medicine & rehabilitation.

[114]  D. Fields,et al.  Resistance training increases total energy expenditure and free-living physical activity in older adults. , 2000, Journal of applied physiology.

[115]  C. Snow,et al.  High Intensity Resistance Training: Effects on Bone in Older Men and Women , 2000, Calcified Tissue International.

[116]  J. Nauta,et al.  Additional weight-bearing during exercise is more important than duration of exercise for anabolic stimulus of bone: a study of running exercise in female rats. , 1995, Bone.

[117]  K M Khan,et al.  A school-based exercise intervention augments bone mineral accrual in early pubertal girls. , 2001, The Journal of pediatrics.

[118]  Pedro Teixeira,et al.  Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy , 2003, Osteoporosis International.

[119]  M. Mussolino,et al.  Jogging and bone mineral density in men: results from NHANES III. , 2001, American journal of public health.

[120]  L. Lanyon,et al.  Human Osteoblasts' Proliferative Responses to Strain and 17β‐Estradiol Are Mediated by the Estrogen Receptor and the Receptor for Insulin‐Like Growth Factor I , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[121]  W. Kohrt,et al.  Additive effects of weight‐bearing exercise and estrogen on bone mineral density in older women , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[122]  I M Vuori,et al.  Dose-response of physical activity and low back pain, osteoarthritis, and osteoporosis. , 2001, Medicine and science in sports and exercise.

[123]  M. Lunt,et al.  Determinants of bone density and prevalence of osteopenia among female runners in their second to seventh decades of age. , 2000, Bone.

[124]  S. Cummings,et al.  Epidemiology and outcomes of osteoporotic fractures , 2002, The Lancet.

[125]  C. Cooper,et al.  Physical inactivity is an independent risk factor for hip fracture in the elderly. , 1993, Journal of epidemiology and community health.

[126]  Mikel Aickin,et al.  Effects of resistance training on regional and total bone mineral density in premenopausal women: A randomized prospective study , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[127]  D. Bauer,et al.  Physical Activity and Osteoporotic Fracture Risk in Older Women , 1998, Annals of Internal Medicine.

[128]  R R Recker,et al.  Bone gain in young adult women. , 1992, JAMA.

[129]  C. Snow,et al.  Exercise and bone mass in young and premenopausal women. , 1996, Bone.

[130]  S B Roberts,et al.  Exercise training and nutritional supplementation for physical frailty in very elderly people. , 1994, The New England journal of medicine.