Digitoxin and its analogs as novel cancer therapeutics
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Cerasela Zoica Dinu | C. Dinu | Y. Rojanasakul | Todd A Stueckle | Yon Rojanasakul | T. Stueckle | W. Tse | Hosam A Elbaz | William Tse | H. Elbaz
[1] A. Egloff,et al. Evaluation of Anticyclin B1 Serum Antibody as a Diagnostic and Prognostic Biomarker for Lung Cancer , 2005, Annals of the New York Academy of Sciences.
[2] Johannes Rinn,et al. Ras/Erk MAPK Signaling in Epidermal Homeostasis and Neoplasia , 2007, Cell cycle.
[3] H. Brewer. Historical perspectives on health , 2004, The journal of the Royal Society for the Promotion of Health.
[4] R. Huxtable. The erroneous pharmacology of a cat. , 2001, Molecular Interventions.
[5] J. M. Langenhan,et al. Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins. , 2008, Bioorganic & medicinal chemistry letters.
[6] M. López-Lázaro. Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved , 2007, Expert opinion on therapeutic targets.
[7] A. Multani,et al. AnvirzelTM, an extract of Nerium oleander, induces cell death in human but not murine cancer cells , 2000, Anti-cancer drugs.
[8] S. Wheatley,et al. Liaisons between Survivin and Plk1 during Cell Division and Cell Death , 2010, The Journal of Biological Chemistry.
[9] T. Smith. Digitalis toxicity: epidemiology and clinical use of serum concentration measurements. , 1975, The American journal of medicine.
[10] S. Rahimtoola,et al. The use of digitalis in heart failure. , 1996, Current problems in cardiology.
[11] Y. Rojanasakul,et al. Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell. , 2011, ACS medicinal chemistry letters.
[12] R. Götz,et al. Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression , 2008, Cancer Cell International.
[13] Tak W. Mak,et al. Pathways of apoptotic and non-apoptotic death in tumour cells , 2004, Nature Reviews Cancer.
[14] H. Schatzmann,et al. [Inhibition of the active Na-K-transport and Na-K-activated membrane ATP-ase of erythrocyte stroma by ouabain]. , 1965, Helvetica physiologica et pharmacologica acta.
[15] K. Winnicka,et al. Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells , 2007, Archives of pharmacal research.
[16] J. Kaplan. Membrane cation transport and the control of proliferation of mammalian cells. , 1978, Annual review of physiology.
[17] T. Lawrence. Ouabain sensitizes tumor cells but not normal cells to radiation. , 1987, International journal of radiation oncology, biology, physics.
[18] Abe. J. Goldin,et al. DIGITALIS AND CANCER , 1984, The Lancet.
[19] J. Chambard,et al. ERK and cell death: Mechanisms of ERK‐induced cell death – apoptosis, autophagy and senescence , 2010, The FEBS journal.
[20] P. Khavari,et al. Erk1/2 MAP kinases are required for epidermal G2/M progression , 2009, The Journal of cell biology.
[21] J. Hartley,et al. Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[22] Fengzhi Li,et al. Control of apoptosis and mitotic spindle checkpoint by survivin , 1998, Nature.
[23] L. Nutt,et al. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. , 2000, Cancer research.
[24] T. Yoshida,et al. Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells. , 1995, Leukemia research.
[25] E. Bengtsson,et al. Cardiac glycosides and breast cancer, revisited. , 1982, The New England journal of medicine.
[26] S. Weed,et al. Regulation of c-SRC Activity and Function by the Adapter Protein CAS , 2000, Molecular and Cellular Biology.
[27] Fengzhi Li,et al. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function , 1999, Nature Cell Biology.
[28] Dong-Hoon Kim. Prognostic Implications of Cyclin B1, p34cdc2, p27Kip1 and p53 Expression in Gastric Cancer , 2007, Yonsei medical journal.
[29] S. Manna,et al. Oleandrin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 and potentiates apoptosis induced by ceramide. , 2003, Biochemical pharmacology.
[30] A. Fornace,et al. p38 MAP kinase's emerging role as a tumor suppressor. , 2004, Advances in cancer research.
[31] Derek K. Rogalsky,et al. A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis. , 2010, ACS medicinal chemistry letters.
[32] W. Hittelman,et al. Oleandrin-mediated oxidative stress in human melanoma cells. , 2006, Journal of experimental therapeutics & oncology.
[33] T. Yoshida,et al. Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs. , 1997, Leukemia research.
[34] F. Hoffmann,et al. Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[35] N. Perkins,et al. Retracted: A cell cycle regulatory network controlling NF‐κB subunit activity and function , 2007, The EMBO journal.
[36] J. Medina-Franco,et al. The prince and the pauper. A tale of anticancer targeted agents , 2008, Molecular Cancer.
[37] E. Grande,et al. The dual kinase complex FAK-Src as a promising therapeutic target in cancer , 2010, OncoTargets and therapy.
[38] Lijun Liu,et al. On the importance and mechanism of amplification of digitalis signal through Na+/K+-ATPase. , 2006, Cellular and molecular biology.
[39] Zijian Xie,et al. Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function. , 2003, Molecular interventions.
[40] David I. Smith,et al. Genome‐wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray , 2006, International journal of cancer.
[41] Jun O. Liu,et al. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth , 2008, Proceedings of the National Academy of Sciences.
[42] K. Chou,et al. Tamoxifen-Induced Increases in Cytoplasmic Free Ca2+ Levels in Human Breast Cancer Cells , 2004, Breast Cancer Research and Treatment.
[43] B. Tombal,et al. Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells. , 2004, Cell calcium.
[44] Y. Nakagawa,et al. Role of calcium-induced mitochondrial hydroperoxide in induction of apoptosis of RBL2H3 cells with eicosapentaenoic acid treatment , 2005, Free radical research.
[45] I. Larre,et al. Ouabain Binding to Na+,K+-ATPase Relaxes Cell Attachment and Sends a SpecificSignal (NACos) to the Nucleus , 2004, The Journal of Membrane Biology.
[46] B. Zhivotovsky,et al. Death through a tragedy: mitotic catastrophe , 2008, Cell Death and Differentiation.
[47] B. Gabrielli,et al. Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. , 2000, Experimental cell research.
[48] R. Agami,et al. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension , 2003, The EMBO journal.
[49] M. Watabe,et al. Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells , 1999, Oncogene.
[50] G Eklund,et al. Evidence of a modifying influence of heart glucosides on the development of breast cancer. , 1980, Analytical and quantitative cytology.
[51] G. O'Doherty,et al. The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin. , 2008, Current topics in medicinal chemistry.
[52] Lijun Liu,et al. Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells , 2005, Molecular Pharmacology.
[53] G. Stark,et al. Control of the G2/M transition , 2006, Molecular biotechnology.
[54] J. Lingrel,et al. Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms. , 1989, The Journal of biological chemistry.
[55] E. Lewinn. CARDIAC GLYCOSIDES AND BREAST CANCER , 1979, The Lancet.
[56] N. K. Sah,et al. Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. , 2000, Cancer research.
[57] O. Shiratori. GROWTH INHIBITORY EFFECT OF CARDIAC GLYCOSIDES AND AGLYCONES ON NEOPLASTIC CELLS , 1967 .
[58] Jiang Tian,et al. Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex. , 2005, Molecular biology of the cell.
[59] S. Manna,et al. Retraction Note: Oleandrin-Mediated Expression of Fas Potentiates Apoptosis in Tumor Cells , 2006, Journal of Clinical Immunology.
[60] P. S. Wang,et al. Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells. , 2001, The Journal of urology.
[61] A. Marchetti,et al. Survivin gene expression in early‐stage non‐small cell lung cancer , 2003, The Journal of pathology.
[62] K. Zinkiewicz,et al. Assessment of prognostic significance of cytoplasmic survivin expression in advanced oesophageal cancer. , 2004, Folia histochemica et cytobiologica.
[63] M. Karamouzis,et al. The Activator Protein-1 Transcription Factor in Respiratory Epithelium Carcinogenesis , 2007, Molecular Cancer Research.
[64] C. Duckett,et al. Acute Ablation of Survivin Uncovers p53-dependent Mitotic Checkpoint Functions and Control of Mitochondrial Apoptosis* , 2004, Journal of Biological Chemistry.
[65] R. Sutherland,et al. Expression and prognostic significance of cyclin B1 and cyclin A in non‐small cell lung cancer , 2009, Histopathology.
[66] J. Williams,et al. Effects of arrhythmia-producing concentrations of digitoxin on mechanical performance of cat myocardium. , 1983, American heart journal.
[67] Jiri Bartek,et al. Targeting the checkpoint kinases: chemosensitization versus chemoprotection , 2004, Nature Reviews Cancer.
[68] J. Haux. Digitoxin is a potential anticancer agent for several types of cancer. , 1999, Medical hypotheses.
[69] H. Kuwano,et al. The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[70] Shaomeng Wang,et al. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. , 2009, Cancer research.
[71] C. Ling,et al. Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. , 2007, World journal of gastroenterology.
[72] R. Newman,et al. Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin. , 2001, Biochemical pharmacology.
[73] Y. Rojanasakul,et al. C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity. , 2011, ACS medicinal chemistry letters.
[74] Jean-Luc Coll,et al. Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth , 2009, Nucleic acids research.
[75] S. Stacker,et al. Targeting lymphatic vessel functions through tyrosine kinases , 2010, Journal of angiogenesis research.
[76] Y. Kondo,et al. Autophagic Cell Death of Human Pancreatic Tumor Cells Mediated by Oleandrin, a Lipid-Soluble Cardiac Glycoside , 2007, Integrative cancer therapies.
[77] D. Bell-Pedersen,et al. A connection between MAPK pathways and circadian clocks , 2008, Cell cycle.
[78] G. Gorbsky,et al. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity , 2004, Journal of Cell Science.
[79] C. Sheline,et al. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. , 2003, Journal of cell science.
[80] S. Azrak,et al. Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. , 2005, Journal of natural products.
[81] M. Gheorghiade,et al. Contemporary Use of Digoxin in the Management of Cardiovascular Disorders , 2006, Circulation.
[82] M. Medarde,et al. A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues , 2000 .
[83] L. Milas,et al. Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process. , 2002, Cancer letters.
[84] Liying Wang,et al. Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells. , 2012, Toxicology and applied pharmacology.
[85] M. Inoue,et al. Structure-cytotoxic activity relationship for the toad poison bufadienolides. , 1998, Bioorganic & medicinal chemistry.
[86] A. Rajasekaran,et al. Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. , 2005, Molecular biology of the cell.
[87] Massimo Milione,et al. Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells. , 2007, Endocrine-related cancer.
[88] Eleftherios P. Diamandis,et al. Novel therapeutic applications of cardiac glycosides , 2008, Nature Reviews Drug Discovery.
[89] W. Zidek,et al. Proscillaridin A immunoreactivity: its purification, transport in blood by a specific binding protein and its correlation with blood pressure. , 1998, Clinical and experimental hypertension.
[90] X. Wang,et al. LC/MS/MS analyses of an oleander extract for cancer treatment. , 2000, Analytical chemistry.
[91] K. Breithaupt-Grögler,et al. Treatment of congestive heart failure - current status of use of digitoxin , 2001 .
[92] M. Masnyk,et al. The lead structure in cardiac glycosides is 5 beta, 14 beta-androstane-3 beta 14-diol. , 1985, Naunyn-Schmiedeberg's archives of pharmacology.
[93] Y. Rojanasakul,et al. Synthesis and Evaluation of the α-d-/α-l-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Antitumor Agents , 2011 .
[94] Alain C. Mita,et al. Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics , 2008, Clinical Cancer Research.
[95] J. Kaplan,et al. Biochemistry of Na,K-ATPase. , 2002, Annual review of biochemistry.
[96] J. Hartley,et al. Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor , 2005 .
[97] B. Kahn,et al. Multiple Signal Transduction Pathways Link Na+/K+-ATPase to Growth-related Genes in Cardiac Myocytes , 1998, The Journal of Biological Chemistry.
[98] K. Strebhardt,et al. Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells , 2004, Oncogene.
[99] T. Padilla-Benavides,et al. Ouabain modulates epithelial cell tight junction , 2010, Proceedings of the National Academy of Sciences.
[100] K. Milde-Langosch,et al. Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators , 2001, Journal of Cancer Research and Clinical Oncology.
[101] Paulus S. Wang,et al. Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells , 2003, The Prostate.
[102] S. Keyse,et al. Dual-specificity MAP kinase phosphatases (MKPs) and cancer , 2008, Cancer and Metastasis Reviews.
[103] U. Bavendiek,et al. Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis? , 2009, Atherosclerosis.
[104] L. Bohlin,et al. Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. , 2009, Journal of natural products.
[105] A. Askari,et al. Partial Inhibition of Na/K-ATPase by Ouabain Induces the Ca-dependent Expressions of Early-response Genes in Cardiac Myocytes (*) , 1996, The Journal of Biological Chemistry.
[106] I. Gelman,et al. SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis , 2006, BMC Cancer.
[107] S. Manna,et al. Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity. , 2007, Molecular immunology.
[108] Zijian Xie,et al. Role of Protein Kinase C in the Signal Pathways That Link Na+/K+-ATPase to ERK1/2* , 2001, The Journal of Biological Chemistry.
[109] H. Mukhtar,et al. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin. , 2004, Toxicology and applied pharmacology.
[110] K. Winnicka,et al. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A. , 2006, Biological & pharmaceutical bulletin.
[111] Takemi Yoshida,et al. Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 Cells , 1994, Japanese journal of cancer research : Gann.
[112] B. Stenkvist. Is digitalis a therapy for breast carcinoma? , 1999, Oncology reports.
[113] K. Winnicka,et al. Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts , 2010, Natural product research.
[114] J. Casanova,et al. FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing , 2011, PloS one.
[115] M. Watabe,et al. The Cooperative Interaction of Two Different Signaling Pathways in Response to Bufalin Induces Apoptosis in Human Leukemia U937 Cells* , 1996, The Journal of Biological Chemistry.
[116] Jiri Bartek,et al. Chk1 and Chk2 kinases in checkpoint control and cancer. , 2003, Cancer cell.
[117] Robert A Newman,et al. Cardiac glycosides as novel cancer therapeutic agents. , 2008, Molecular interventions.
[118] J. Shapiro,et al. Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and Its Marker Genes in Cardiac Myocytes* , 1999, The Journal of Biological Chemistry.
[119] Peiqing Sun,et al. The pathways to tumor suppression via route p38. , 2007, Trends in biochemical sciences.
[120] Y. Hasin,et al. Sodium Pump Inhibition, Enhanced Calcium Influx via Sodium‐Calcium Exchange, and Positive Inotropic Response in Cultured Heart Cells , 1985, Circulation research.
[121] Radhey S. Gupta,et al. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis) , 1986, Journal of cellular physiology.
[122] Jiang Tian,et al. Functional Characterization of Src-interacting Na/K-ATPase Using RNA Interference Assay* , 2006, Journal of Biological Chemistry.
[123] K. Winnicka,et al. Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells. , 2008, Biological & pharmaceutical bulletin.
[124] Lijun Liu,et al. Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype. , 2004, American journal of physiology. Heart and circulatory physiology.
[125] Hung-Jen Liu,et al. Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways , 2009, Veterinary research.
[126] M. Suraokar,et al. Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na,K-ATPase α subunits as drug targets , 2008, Molecular Cancer Therapeutics.
[127] Jiang Tian,et al. Src-mediated Inter-receptor Cross-talk between the Na+/K+-ATPase and the Epidermal Growth Factor Receptor Relays the Signal from Ouabain to Mitogen-activated Protein Kinases* , 2002, The Journal of Biological Chemistry.
[128] Jian Zhang,et al. Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[129] Kyungeun Kim,et al. Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications , 2011, Yonsei medical journal.
[130] Guido Kroemer,et al. Cell death by mitotic catastrophe: a molecular definition , 2004, Oncogene.
[131] G. Scheiner-Bobis,et al. Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. , 2007, American journal of physiology. Cell physiology.
[132] O. Shiratori. Growth inhibitory effect of cardiac glycosides and aglycones on neoplastic cells: in vitro and in vivo studies. , 1967, Gan.
[133] K. Breithaupt-Grögler,et al. Treatment of congestive heart failure – current status of use of digitoxin , 2001, European journal of clinical investigation.
[134] A. Røseth,et al. Prolonged digitoxin half-life in very elderly patients. , 1998, Age and ageing.
[135] L. Bohlin,et al. Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells , 2001, Anti-cancer drugs.