The global impact of Alzheimer’s Disease (AD) on the cerebral cortex is still not fully understood. The ability to analyze the changes in cortical thickness across the whole cortex thus provides an exciting opportunity to gain further insight into the spatial distribution and extent of cortical atrophy in the disease. In the present work, we were able to use deformable models to fit the inner and outer cortical surfaces of 42 T1 MRI scans (25 AD, 17 controls) and compute the cortical thickness at every vertex of the surface. Statistical analysis was then performed comparing both clinical state and Mini-Mental State Exam (MMSE) scores against cortical thickness.