Glowing Tumors Make for Better Detection and Resection

Tumor-specific fluorescent probes that can be administered topically make tumors selectively fluorescent and thus have great potential for improving cancer detection and removal. Tumor-specific fluorescent probes that can be administered topically make tumors glow selectively and thus have great potential for improving cancer detection and removal.

[1]  Sharmeela Kaushal,et al.  Imaging of Primary and Metastatic Pancreatic Cancer Using a Fluorophore-Conjugated Anti-CA19-9 Antibody for Surgical Navigation , 2008, World Journal of Surgery.

[2]  V. Rusch,et al.  Minimally invasive localization of oncolytic herpes simplex viral therapy of metastatic pleural cancer , 2006, Cancer Gene Therapy.

[3]  F. Zanella,et al.  Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. , 2006, The Lancet. Oncology.

[4]  Sharmeela Kaushal,et al.  Submillimeter-resolution fluorescence laparoscopy of pancreatic cancer in a carcinomatosis mouse model visualizes metastases not seen with standard laparoscopy. , 2011, Journal of laparoendoscopic & advanced surgical techniques. Part A.

[5]  M. Bouvet,et al.  Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection , 2011, Cell cycle.

[6]  L. Ngo,et al.  The FLARE™ Intraoperative Near-Infrared Fluorescence Imaging System: A First-in-Human Clinical Trial in Breast Cancer Sentinel Lymph Node Mapping , 2009, Annals of Surgical Oncology.

[7]  P. Low,et al.  Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results , 2011, Nature Medicine.

[8]  Peter L. Choyke,et al.  Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe , 2011, Science Translational Medicine.

[9]  Miriam Scadeng,et al.  Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival , 2010, Proceedings of the National Academy of Sciences.

[10]  Katsuhiro Hayashi,et al.  In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation , 2009, Proceedings of the National Academy of Sciences.