Microencapsulated stem cells reduce cartilage damage in a material dependent manner following minimally invasive intra-articular injection in an OA rat model

[1]  V. Badalamoole,et al.  Past, present and future of biomedical applications of dextran-based hydrogels: A review. , 2022, International journal of biological macromolecules.

[2]  Andrés J. García,et al.  FasL microgels induce immune acceptance of islet allografts in nonhuman primates , 2022, Science advances.

[3]  Ting Yang,et al.  Gelatin methacryloyl-alginate core-shell microcapsules as efficient delivery platforms for prevascularized microtissues in endodontic regeneration. , 2022, Acta biomaterialia.

[4]  D. Kelly,et al.  Soft Hydrogel Environments that Facilitate Cell Spreading and Aggregation Preferentially Support Chondrogenesis of Adult Stem Cells. , 2022, Macromolecular bioscience.

[5]  Lanfang Wang,et al.  Sodium alginate microencapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis. , 2021, Acta biomaterialia.

[6]  Niels G A Willemen,et al.  Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials (Adv. Mater. 42/2021) , 2021, Advanced Materials.

[7]  Niels G A Willemen,et al.  Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials , 2021, Advanced materials.

[8]  W. Cui,et al.  Stem Cell‐Recruiting Injectable Microgels for Repairing Osteoarthritis , 2021, Advanced Functional Materials.

[9]  H. Young,et al.  Cytokines: From Clinical Significance to Quantification , 2021, Advanced science.

[10]  Qiuming Wang,et al.  Cell-free decellularized cartilage extracellular matrix scaffolds combined with interleukin 4 promote osteochondral repair through immunomodulatory macrophages: in vitro and in vivo preclinical study. , 2021, Acta biomaterialia.

[11]  Y. Koh,et al.  Intra-articular injection of human synovium-derived mesenchymal stem cells in beagles with surgery-induced osteoarthritis. , 2020, The Knee.

[12]  L. McNamara,et al.  Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration , 2020, Frontiers in Bioengineering and Biotechnology.

[13]  Geonhui Lee,et al.  Mechanical Properties of Materials for Stem Cell Differentiation , 2020, Advanced biosystems.

[14]  Christopher D. Davidson,et al.  Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation , 2020, Science Advances.

[15]  Z. Gu,et al.  VE-cadherin functionalized injectable PAMAM/HA hydrogel promotes endothelial differentiation of hMSCs and vascularization , 2020 .

[16]  Andrés J. García,et al.  Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival , 2020, Science Advances.

[17]  S. Mohapatra,et al.  Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury. , 2020, Nanomedicine : nanotechnology, biology, and medicine.

[18]  J. Verhaar,et al.  MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study , 2020, Cell Biology and Toxicology.

[19]  D. Kaplan,et al.  Microskin‐Inspired Injectable MSC‐Laden Hydrogels for Scarless Wound Healing with Hair Follicles , 2020, Advanced healthcare materials.

[20]  D. Mooney,et al.  Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration , 2020, Advanced functional materials.

[21]  T. Kamperman,et al.  Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation , 2020, Materials today. Bio.

[22]  A. Lam,et al.  Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs. , 2020, Stem cell research.

[23]  R. Riddell.  Healing and Repair , 2020 .

[24]  Nicholas M. Wragg,et al.  Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis , 2020, Knee Surgery, Sports Traumatology, Arthroscopy.

[25]  Xiaoping Bao,et al.  Biomaterials for stem cell engineering and biomanufacturing , 2019, Bioactive materials.

[26]  Jee‐Heon Jeong,et al.  Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives. , 2019, European journal of cell biology.

[27]  R. Erben,et al.  Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs , 2019, Scientific Reports.

[28]  Harish Poptani,et al.  Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration , 2018, Stem Cell Research & Therapy.

[29]  S. Son,et al.  In vivo migration of mesenchymal stem cells to burn injury sites and their therapeutic effects in a living mouse model , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[30]  M. Renner,et al.  Cytokine‐induced interleukin‐1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment , 2018, The journal of gene medicine.

[31]  A. Mohr,et al.  The future of mesenchymal stem cell-based therapeutic approaches for cancer - From cells to ghosts. , 2018, Cancer letters.

[32]  Heungsoo Shin,et al.  Hybrid-spheroids incorporating ECM like engineered fragmented fibers potentiate stem cell function by improved cell/cell and cell/ECM interactions. , 2017, Acta biomaterialia.

[33]  F. Papaccio,et al.  Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development , 2017, Stem cells translational medicine.

[34]  C. G. Fontanella,et al.  Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study , 2017, Rheumatology.

[35]  F. Guilak,et al.  CXCL10 is upregulated in synovium and cartilage following articular fracture , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[36]  H. Weinans,et al.  Metabolic dysregulation accelerates injury‐induced joint degeneration, driven by local inflammation; an in vivo rat study , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[37]  Marcel Karperien,et al.  Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape. , 2017, Small.

[38]  Liming Bian,et al.  Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy. , 2017, Acta biomaterialia.

[39]  A. Goldberg,et al.  The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review , 2017, Journal of Orthopaedic Surgery and Research.

[40]  G. Tae,et al.  Heparin-hyaluronic acid hydrogel in support of cellular activities of 3D encapsulated adipose derived stem cells. , 2017, Acta biomaterialia.

[41]  Matthias W Laschke,et al.  Life is 3D: Boosting Spheroid Function for Tissue Engineering. , 2017, Trends in biotechnology.

[42]  I. Kerkis,et al.  Allogeneic Mesenchymal Stem Cell Transplantation in Dogs With Keratoconjunctivitis Sicca. , 2016, Cell medicine.

[43]  A. van den Berg,et al.  Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels. , 2016, Macromolecular bioscience.

[44]  E. Andreu,et al.  Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II) , 2016, Journal of Translational Medicine.

[45]  M. Jaafari,et al.  Mesenchymal stem cell: a new horizon in cancer gene therapy , 2016, Cancer Gene Therapy.

[46]  H. Weinans,et al.  Groove model of tibia‐femoral osteoarthritis in the rat , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[47]  E. Raharjo,et al.  Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model , 2016, Scientific Reports.

[48]  A. Steward,et al.  Mechanical regulation of mesenchymal stem cell differentiation , 2015, Journal of anatomy.

[49]  P. Campbell,et al.  The Synovial Lining and Synovial Fluid Properties after Joint Arthroplasty , 2015 .

[50]  J. Karp,et al.  Mesenchymal stem cells: immune evasive, not immune privileged , 2014, Nature Biotechnology.

[51]  Garry E Gold,et al.  Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite , 2013, Science Translational Medicine.

[52]  K. Tamama,et al.  Acceleration of Wound Healing by Multiple Growth Factors and Cytokines Secreted from Multipotential Stromal Cells/Mesenchymal Stem Cells. , 2012, Advances in wound care.

[53]  G. Gurtner,et al.  Mesenchymal Stem Cells Home to Sites of Injury and Inflammation. , 2012, Advances in wound care.

[54]  A. Das,et al.  Mesenchymal stem cells for cartilage repair in osteoarthritis , 2012, Stem Cell Research & Therapy.

[55]  P. Gillet,et al.  Cytokines profiling by multiplex analysis in experimental arthritis: which pathophysiological relevance for articular versus systemic mediators? , 2012, Arthritis Research & Therapy.

[56]  B. Seliger,et al.  The immunomodulatory capacity of mesenchymal stem cells. , 2012, Trends in molecular medicine.

[57]  J. Feijen,et al.  Injectable Hydrogels by Enzymatic Co-Crosslinking of Dextran and Hyaluronic Acid Tyramine Conjugates , 2011 .

[58]  C A van Blitterswijk,et al.  Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran-hyaluronic acid conjugates for cartilage tissue engineering. , 2010, Biomaterials.

[59]  M. Joglekar,et al.  Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. , 2009, Cytotherapy.

[60]  Christoph Gaissmaier,et al.  Growth and differentiation factors for cartilage healing and repair. , 2008, Injury.

[61]  J. Hui,et al.  Injectable Mesenchymal Stem Cell Therapy for Large Cartilage Defects—A Porcine Model , 2007, Stem cells.

[62]  A. Poncelet,et al.  Although Pig Allogeneic Mesenchymal Stem Cells Are Not Immunogenic In Vitro, Intracardiac Injection Elicits an Immune Response In Vivo , 2007, Transplantation.

[63]  K. Kuettner,et al.  Cartilage degeneration in different human joints. , 2005, Osteoarthritis and cartilage.

[64]  Yi Li,et al.  Treatment of neural injury with marrow stromal cells , 2002, The Lancet Neurology.

[65]  K. Nishioka,et al.  Role of chemokines/chemokine receptor systems in cartilage degradation. , 2001, Drug news & perspectives.

[66]  Thomas Aigner,et al.  Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis , 2001, Arthritis Research & Therapy.

[67]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[68]  Mehana E El-Sayed,et al.  The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review. , 2019, Life sciences.

[69]  L. Kaplan,et al.  Mesenchymal Stem Cell Therapies in the Treatment of Musculoskeletal Diseases , 2014, PM & R : the journal of injury, function, and rehabilitation.

[70]  A. Bendele,et al.  The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat. , 2010, Osteoarthritis and cartilage.

[71]  T. Griffin,et al.  Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. , 2008, Biorheology.

[72]  K. Kraus,et al.  Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects. , 2002, Biomaterials.