Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.

[1]  R. Blakely,et al.  Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter , 2015, ACS chemical neuroscience.

[2]  Michael J Higley,et al.  Neuromodulation by acetylcholine: examples from schizophrenia and depression , 2014, Current Opinion in Neurobiology.

[3]  T. Haga.  Molecular properties of the high-affinity choline transporter CHT1. , 2014, Journal of biochemistry.

[4]  M. Hurles,et al.  Defective presynaptic choline transport underlies hereditary motor neuropathy. , 2012, American journal of human genetics.

[5]  R. Blakely,et al.  Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake. , 2012, ACS chemical neuroscience.

[6]  S. Manuck,et al.  Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans , 2012, The International Journal of Cardiovascular Imaging.

[7]  Randy D. Blakely,et al.  Choline transporter gene variation is associated with attention-deficit hyperactivity disorder , 2009, Journal of Neurodevelopmental Disorders.

[8]  B A English,et al.  Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression , 2008, Genes, brain, and behavior.

[9]  Randy D Blakely,et al.  Na+, Cl−, and pH Dependence of the Human Choline Transporter (hCHT) in Xenopus Oocytes: The Proton Inactivation Hypothesis of hCHT in Synaptic Vesicles , 2006, The Journal of Neuroscience.

[10]  D. Wilkes,et al.  The Caenorhabditis elegans Choline Transporter CHO-1 Sustains Acetylcholine Synthesis and Motor Function in an Activity-Dependent Manner , 2006, The Journal of Neuroscience.

[11]  J. Tapia,et al.  Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Randy D Blakely,et al.  The choline transporter resurfaces: new roles for synaptic vesicles? , 2004, Molecular interventions.

[13]  A. Passmore,et al.  Acetylcholinesterase inhibitors in Alzheimer's disease. , 1999, British journal of clinical pharmacology.

[14]  L. A. Carpino.  1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive , 1993 .

[15]  D L Price,et al.  Alzheimer's disease: a disorder of cortical cholinergic innervation. , 1983, Science.

[16]  O. Mitsunobu.  The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products , 1981 .

[17]  J. Rossier,et al.  Inhibition by hemicholinium-3 of (14C)acetylcholine synthesis and (3H)choline high-affinity uptake in rat striatal synaptosomes. , 1973, Molecular pharmacology.

[18]  S. Snyder,et al.  Choline: High-Affinity Uptake by Rat Brain Synaptosomes , 1972, Science.

[19]  F. Schueler.  A new group of respiratory paralyzants. I. The "hemicholiniums". , 1955, The Journal of pharmacology and experimental therapeutics.

[20]  E. Perry,et al.  Neurochemistry of consciousness: cholinergic pathologies in the human brain. , 2004, Progress in brain research.

[21]  K. Ohno,et al.  Congenital myasthenic syndromes: Genetic defects of the neuromuscular junction , 2002, Current neurology and neuroscience reports.

[22]  S. Hyman,et al.  Molecular Neuropharmacology: A Foundation for Clinical Neuroscience , 2001 .

[23]  Bb Hoffman.  Neurotransmission: The autonomic and somatic motor nervous systems , 1996 .