Inducible secretion of large, biologically potent von Willebrand factor multimers

[1]  D. Bonthron,et al.  Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. , 1986, Science.

[2]  T. Mayadas,et al.  Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor , 1986, The Journal of cell biology.

[3]  R. Kelly Pathways of protein secretion in eukaryotes. , 1985, Science.

[4]  I. Charo,et al.  Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa. , 1985, The Journal of biological chemistry.

[5]  D. Meyer,et al.  Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies. , 1985, Blood.

[6]  D. Wagner,et al.  Biosynthesis of von Willebrand protein by human megakaryocytes. , 1985, The Journal of clinical investigation.

[7]  R. Montgomery,et al.  Endothelial cell synthesis of von Willebrand antigen II, von Willebrand factor, and von Willebrand factor/von Willebrand antigen II complex. , 1985, The Journal of clinical investigation.

[8]  P. D. de Groot,et al.  Comparison of secretion and subcellular localization of von Willebrand protein with that of thrombospondin and fibronectin in cultured human vascular endothelial cells. , 1985, Biochimica et biophysica acta.

[9]  A. Yalçin,et al.  A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells. , 1985, The Journal of clinical investigation.

[10]  D. Wagner,et al.  Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization , 1984, The Journal of cell biology.

[11]  H. Weiss,et al.  Platelet interaction with rabbit subendothelium in von Willebrand's disease: altered thrombus formation distinct from defective platelet adhesion. , 1984, The Journal of clinical investigation.

[12]  H. Gralnick,et al.  Fibrinogen competes with von Willebrand factor for binding to the glycoprotein IIb/IIIa complex when platelets are stimulated with thrombin. , 1984, Blood.

[13]  P. D. de Groot,et al.  Isolation of a storage and secretory organelle containing Von Willebrand protein from cultured human endothelial cells. , 1984, Biochimica et biophysica acta.

[14]  V. Lehto,et al.  Intracellular localization of factor VIII-related antigen and fibronectin in cultured human endothelial cells: evidence for divergent routes of intracellular translocation. , 1984, European journal of cell biology.

[15]  D. Livingston,et al.  Subunit composition of oligomeric human von Willebrand factor. , 1983, The Journal of biological chemistry.

[16]  P. D. de Groot,et al.  The effect of calcium on the secretion of factor VIII-related antigen by cultured human endothelial cells. , 1983, Biochimica et biophysica acta.

[17]  R. Montgomery,et al.  Platelets have more than one binding site for von Willebrand factor. , 1983, The Journal of clinical investigation.

[18]  D. Wagner,et al.  Biosynthesis of von Willebrand protein by human endothelial cells. Identification of a large precursor polypeptide chain. , 1983, The Journal of biological chemistry.

[19]  D. Wagner,et al.  Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells , 1982, The Journal of cell biology.

[20]  L. Harker,et al.  Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture. , 1982, Blood.

[21]  P. Mannucci,et al.  Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes , 1982 .

[22]  R. Kelly,et al.  Two distinct intracellular pathways transport secretory and membrane glycoproteins to the surface of pituitary tumor cells , 1982, Cell.

[23]  C. Francis,et al.  Structural studies of the functional heterogeneity of von Willebrand protein polymers , 1981 .

[24]  R. Kelly,et al.  Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[25]  L. Hoyer,et al.  Factor VIII-related protein circulates in normal human plasma as high molecular weight multimers , 1980 .

[26]  Z. Ruggeri,et al.  Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets. , 1980, The Journal of clinical investigation.

[27]  K. Kaplan,et al.  Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen. , 1979, The Journal of laboratory and clinical medicine.

[28]  J. Sixma,et al.  Human blood platelet adhesion to artery subendothelium is mediated by factor VIII–Von Willebrand factor bound to the subendothelium , 1979, Nature.

[29]  P. Walsh,et al.  Active release of human platelet factor VIII-related antigen by adenosine diphosphate, collagen, and thrombin. , 1978, The Journal of clinical investigation.

[30]  E. Jaffe,et al.  Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. , 1977, The Journal of clinical investigation.

[31]  I. Sussman,et al.  Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. , 1977, The Journal of clinical investigation.

[32]  P. Mannucci,et al.  Mechanism of Plasminogen Activator and Factor VIII Increase after Vasoactive Drugs , 1975, British journal of haematology.

[33]  J. Folkman,et al.  HUMAN VASCULAR ENDOTHELIAL CELLS IN CULTURE , 1974, The Journal of cell biology.

[34]  H. Weiss,et al.  Decreased adhesion of platelets to subendothelium in von Willebrand's disease. , 1974, The Journal of laboratory and clinical medicine.

[35]  T. Hovig,et al.  Ultrastructural studies on the platelet plug formation in bleeding time wounds from normal individuals and patients with von Willebrand's disease. , 1974, Acta pathologica et microbiologica Scandinavica. Supplement.

[36]  E. Jaffe,et al.  Synthesis of antihemophilic factor antigen by cultured human endothelial cells. , 1973, The Journal of clinical investigation.

[37]  H. Matsuda,et al.  Ultrastructure of "tubular body" in the endothelial cells of the ocular blood vessels. , 1970, Investigative ophthalmology.

[38]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[39]  P. Stoebner,et al.  GOLGI ORIGIN OF TUBULAR INCLUSIONS IN ENDOTHELIAL CELLS , 1970, The Journal of cell biology.

[40]  E. Weibel,et al.  NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA , 1964, The Journal of cell biology.