Biological performance of materials : fundamentals of biocompatibility

Part 1 General considerations: biocompatability - definitions and issues introduction to the biological environment. Part 2 Material response - function and degradation of materials in vivo: swelling and leaching corrosion and dissolution reactions of biological molecules with biomaterial surfaces mechanics of materials - deformation and failure friction and wear implant materials - properties. Part 3 Host response - biological effects of implants: the inflammatory process coagulation and haemolysis adaptation allergic foreign-body response chemical and foreign-body carcinogenesis mineral metabolism systemic distribution and excretion effects of degradation products on remote organ functions diagnosis of host response. Part 4 Methods of test for biological performance: in vitro test methods in vivo implant models qualification of implant materials standardization and regulation of implant materials design and selection of implant materials.