Dissolution rate studies. II. Dissolution of particles under conditions of rapid agitation.

Dissolution data for sized fractions of three different compounds were obtained using the method of Niebergall and Goyan. The Hixon-Crowell "cube root law" did not describe the data. Deviation from this law was accounted for by deriving a rate expression assuming that the thickness of the diffusion layer was proportional to the square root of the mean volume diameter. Experiments were performed to verify the applicability of the equation so derived.