Pyridine-based lanthanide complexes: towards bimodal agents operating as near infrared luminescent and MRI reporters.

We report two prototype Ln(3+) complexes that address requirements for both MRI and luminescence imaging and we demonstrate that the presence of two H(2)O molecules bound to the Ln(3+), beneficial for MRI applications of the Gd(3+) analogue, is not a major limitation for the development of NIR luminescent agents.

[1]  M. Botta,et al.  Modulation of the water exchange rates in [Gd-DO3A] complex by formation of ternary complexes with carboxylate ligands , 2001 .

[2]  S. Laurent,et al.  In vitro characterization of the Gd complex of [2,6-pyridinediylbis(methylene nitrilo)] tetraacetic acid (PMN-tetraacetic acid) and of its Eu analogue, suitable bimodal contrast agents for MRI and optical imaging. , 2007, Bioorganic & medicinal chemistry letters.

[3]  R. Lauffer,et al.  Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications. , 1999, Chemical reviews.

[4]  S. Laurent,et al.  Bimodal system (luminophore and paramagnetic contrastophore) derived from Ln(III) complexes based on a bipyridine-containing macrocyclic ligand. , 2005, Inorganic chemistry.

[5]  R. Weissleder A clearer vision for in vivo imaging , 2001, Nature Biotechnology.

[6]  A. Beeby,et al.  Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states , 1999 .

[7]  David Milstein,et al.  Water-soluble contrast agents targeted at the estrogen receptor for molecular magnetic resonance imaging. , 2007, Bioconjugate chemistry.

[8]  S. Petoud,et al.  Sensitization of near-infrared-emitting lanthanide cations in solution by tropolonate ligands. , 2005, Angewandte Chemie.

[9]  Seth M Cohen,et al.  Stable lanthanide luminescence agents highly emissive in aqueous solution: multidentate 2-hydroxyisophthalamide complexes of Sm(3+), Eu(3+), Tb(3+), Dy(3+). , 2003, Journal of the American Chemical Society.

[10]  J. Bünzli,et al.  Taking advantage of luminescent lanthanide ions. , 2005, Chemical Society reviews.

[11]  J. Bünzli,et al.  A novel strategy for the design of 8-hydroxyquinolinate-based lanthanide bioprobes that emit in the near infrared range. , 2007, Chemistry.

[12]  Thomas J. Meade,et al.  Multimodal MRI contrast agents , 2007, JBIC Journal of Biological Inorganic Chemistry.

[13]  R. J. Aarons,et al.  A luminescent probe containing a tuftsin targeting vector coupled to a terbium complex. , 2006, Chemical communications.

[14]  K. Nicolay,et al.  Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis , 2008 .

[15]  David J. Leggett,et al.  Computational methods for the determination of formation constants , 1985 .

[16]  R. Kauppinen,et al.  Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex. , 2008, Journal of the American Chemical Society.

[17]  J. Frangioni In vivo near-infrared fluorescence imaging. , 2003, Current opinion in chemical biology.

[18]  E. Brücher,et al.  The rates of the exchange reactions between [Gd(DTPA)]2- and the endogenous ions Cu2+ and Zn2+: a kinetic model for the prediction of the in vivo stability of [Gd(DTPA)]2-, used as a contrast agent in magnetic resonance imaging. , 2000, Chemistry.

[19]  Luigi Biancone,et al.  Improved route for the visualization of stem cells labeled with a Gd‐/Eu‐Chelate as dual (MRI and fluorescence) agent , 2004, Magnetic resonance in medicine.