Episodic and semantic memory in mild cognitive impairment

Little is known about episodic and semantic memory in the early predementia stage of Alzheimer's disease (AD), which is referred to as mild cognitive impairment (MCI). To explore person knowledge, item recognition and spatial associative memory, we designed the Face Place Test (FPT). A total of 75 subjects participated: 22 patients with early AD, 24 with MCI and 29 matched controls. As predicted, AD patients showed significant deficits in person naming, item recognition and recall of spatial location (placing). Surprisingly, subjects with MCI were also impaired on all components. There was no significant difference between AD and MCI except on the placing component. Analysis of the relationship between semantic (naming) and episodic (recognition and placing) components of the FPT revealed a significant association between the two episodic tasks, but not between episodic and semantic performance. Patients with MCI show deficits of episodic and semantic memory. The extent of impairment suggests dysfunction beyond the medial temporal lobe. The FPT might form the basis of a sensitive early indicator of AD.

[1]  G. Barba,et al.  The influence of semantic encoding on recognition memory in Alzheimer's disease , 1996, Neuropsychologia.

[2]  H Spinnler,et al.  C ROSSMODAL AGNOSIA FOR FAMILIAR PEOPLE AS A CONSEQUENCE OF RIGHT INFERO POLAR TEMPORAL ATROPHY , 2001, Cognitive neuropsychology.

[3]  Kim S. Graham,et al.  Perceptual and semantic contributions to episodic memory: evidence from semantic dementia and Alzheimer's disease , 2002 .

[4]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[5]  J R Hodges,et al.  Semantic knowledge and episodic memory for faces in semantic dementia. , 2001, Neuropsychology.

[6]  Neil A. Macmillan,et al.  Detection Theory: A User's Guide , 1991 .

[7]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[8]  Martin Rossor,et al.  Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. , 2002, Neurology.

[9]  J. Price,et al.  MRI measures of entorhinal cortex versus hippocampus in preclinical AD. , 2002, Neurology.

[10]  J. Hodges,et al.  Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment , 2003, Annals of neurology.

[11]  B. Sahakian,et al.  Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia , 2001, Neurology.

[12]  C. Price,et al.  Identification of famous faces and buildings: a functional neuroimaging study of semantically unique items. , 2001, Brain : a journal of neurology.

[13]  Larry R Squire,et al.  Recognition Memory for Single Items and for Associations Is Similarly Impaired following Damage to the Hippocampal Region & L E a R N I N G M E M O R Y , 2022 .

[14]  J R Hodges,et al.  Episodic memory: insights from semantic dementia. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[15]  J. Hodges,et al.  Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. , 1992 .

[16]  B. Sahakian,et al.  Is knowledge of famous people disproportionately impaired in patients with early and questionable Alzheimer's disease? , 2002, Neuropsychology.

[17]  Handbook of Neuropsychology and Aging , 1997, Critical Issues in Neuropsychology.

[18]  The Neuropsychology of Alzheimer’s Disease , 2004 .

[19]  T. Robbins,et al.  Early Detection and Differential Diagnosis of Alzheimer’s Disease and Depression with Neuropsychological Tasks , 2001, Dementia and Geriatric Cognitive Disorders.

[20]  J. Hodges,et al.  The fractionation of remote memory. Evidence from a longitudinal study of dementia of Alzheimer type. , 1996, Brain : a journal of neurology.

[21]  Howard Chertkow,et al.  Mild cognitive impairment , 2002, Current opinion in neurology.

[22]  J. Hodges,et al.  Identification of famous faces and famous names in early Alzheimer's disease. Relationship to anterograde episodic and general semantic memory. , 1996, Brain : a journal of neurology.

[23]  C. Semenza,et al.  Anomia for people names in DAT—evidence for semantic and post-semantic impairments , 2003, Neuropsychologia.

[24]  P. Maruff,et al.  The neuropsychology of preclinical Alzheimer's disease and mild cognitive impairment , 2000, Neuroscience & Biobehavioral Reviews.

[25]  J R Hodges,et al.  Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease) , 2003, The European journal of neuroscience.

[26]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[27]  J. Semple,et al.  Paired associate performance in the early detection of DAT , 2002, Journal of the International Neuropsychological Society.

[28]  E Miller,et al.  Recognition memory in elderly patients with depression and dementia: a signal detection analysis. , 1977, Journal of abnormal psychology.

[29]  C. Jack,et al.  Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. , 2004, Archives of neurology.

[30]  L. Rapport,et al.  Validation of the Warrington theory of visual processing and the Visual Object and Space Perception Battery. , 1998, Journal of clinical and experimental neuropsychology.

[31]  M N Rossor,et al.  Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study. , 1998, Brain : a journal of neurology.

[32]  M. Hautus.  Corrections for extreme proportions and their biasing effects on estimated values ofd′ , 1995 .

[33]  M. W. Brown,et al.  Episodic memory, amnesia, and the hippocampal–anterior thalamic axis , 1999, Behavioral and Brain Sciences.

[34]  J. Touchon,et al.  Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study , 2003, Acta psychiatrica Scandinavica.

[35]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[36]  E. Tulving.  Episodic memory and common sense: how far apart? , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[37]  J. G. Snodgrass,et al.  Pragmatics of measuring recognition memory: applications to dementia and amnesia. , 1988, Journal of experimental psychology. General.

[38]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[39]  P. S. Mathuranath,et al.  A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia , 2000, Neurology.

[40]  C. P. Hughes,et al.  A New Clinical Scale for the Staging of Dementia , 1982, British Journal of Psychiatry.

[41]  B. Winblad,et al.  The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample. , 2000, Archives of neurology.

[42]  C. D. de Jager,et al.  Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease , 2003, Psychological Medicine.

[43]  D. Salmon,et al.  The deterioration of semantic networks in patients with Alzheimer's disease: A cross-sectional study , 1997, Neuropsychologia.

[44]  L. Thal,et al.  Alzheimer’s disease can be accurately diagnosed in very mildly impaired individuals , 2002, Neurology.

[45]  D. Schnyer,et al.  A critical role for the anterior hippocampus in relational memory: Evidence from an fMRI study comparing associative and item recognition , 2004, Hippocampus.

[46]  L. Squire,et al.  Simple and associative recognition memory in the hippocampal region. , 2001, Learning & memory.

[47]  C. Stark,et al.  Medial temporal lobe activation during encoding and retrieval of novel face-name pairs , 2004, Hippocampus.

[48]  J. Baron,et al.  Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment. , 2003, Brain : a journal of neurology.

[49]  J. Hodges,et al.  Progressive prosopagnosia associated with selective right temporal atrophy: a new syndrome? , 2002 .

[50]  Alex Martin,et al.  Semantic memory and the brain: structure and processes , 2001, Current Opinion in Neurobiology.

[51]  John R. Hodges,et al.  Progressive prosopagnosia associated with selective right temporal lobe atrophy. A new syndrome? , 1995, Brain : a journal of neurology.

[52]  J. Hodges,et al.  Insights from semantic dementia on the relationship between episodic and semantic memory , 2000, Neuropsychologia.

[53]  M. Albert,et al.  MRI measures of entorhinal cortex vs hippocampus in preclinical AD , 2002, Neurology.

[54]  D. Bub,et al.  Semantic memory loss in dementia of Alzheimer's type. What do various measures measure? , 1990, Brain : a journal of neurology.

[55]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.

[56]  Matthew A. Lambon Ralph,et al.  Longitudinal Profiles of Semantic Impairment for Living and Nonliving Concepts in Dementia of Alzheimer's Type , 2001, Journal of Cognitive Neuroscience.

[57]  C. Semenza,et al.  Proper Names in Patients With Early Alzheimer’s Disease , 2003, Neurocase.

[58]  J. Hodges,et al.  Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications , 1995, Neuropsychologia.

[59]  H. Spinnler,et al.  Cognitive modelling of face processing: Evidence from Alzheimer patients , 1995, Neuropsychologia.