论文信息 - Lipoprotein (a) in ischemic heart disease and cerebrovascular disease.

Lipoprotein (a) in ischemic heart disease and cerebrovascular disease.

Lipoprotein (a) [Lp(a)] was first described by Berg as a genetic variant of low density lipoprotein (LDL) more than twenty-five years ago (1). Lp(a) lipid composition is similar to that of LDL, and floats in a density range of 1.051.125g/ml. Its protein moiety contains a specific glycoprotein, apolipoprotein (a) [apo(a)], in addition to apo B-100. Recently, the cDNA sequence of human apo(a) was determined, and it shows a striking homology with plasminogen (2). This finding may provide a direct link between thrombogenesis and progressive atherosclerosis. We examined the association between Lp(a) concentrations and angiographically assessed atherosclerosis in coronary artery disease and cerebrovascular disease.

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