Confiabilidade de medidas volumétricas de estruturas temporais mesiais

MOTIVO DO ESTUDO: O desenvolvimento de tecnicas confiaveis para a realizacao de medidas volumetricas de estruturas temporais mesiais (amigdala, hipocampo e giro para-hipocampal) em exames de ressonância magnetica (RM) pode fornecer dados para o estudo de varios transtornos neuropsiquiatricos, particularmente epilepsia do lobo temporal, doenca de Alzheimer e esquizofrenia. METODO: Investigamos essas tecnicas realizando estudo de confiabilidade intra-observador (IO) e entre-observador (EO), envolvendo controles normais, pacientes com epilepsia e pacientes com doenca de Alzheimer, atraves do coeficiente de correlacao intra-classe (CCI). RESULTADOS: A confiabilidade IO para as estruturas analisadas variou de 0,93 a 0,99 (p<0,001). A confiabilidade EO variou de 0,70 a 0,95 (p £ 0,001). CONCLUSAO: Os resultados sugerem que a tecnica de morfometria por RM de regioes temporais mesiais constitui instrumento confiavel, que pode auxiliar na investigacao diagnostica de transtornos neuropsiquiatricos, desde que utilizado por clinicos e pesquisadores adequadamente treinados.

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