Enhanced Corrosion Resistance and Biocompatibility of Magnesium Alloy by Mg-Al-Layered Double Hydroxide.

Magnesium (Mg) and its alloys have been suggested as revolutionary biodegradable materials. However, fast degradation hinders its clinic application. To improve the corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy (JDBM), magnesium-aluminum-layered double hydroxide (Mg-Al LDH) was successfully introduced into Mg(OH)2 coating by hydrothermal treatment. The anions in the interlayer of Mg-Al LDH can be replaced by chloride ions, resulting in a relatively low chloride ion concentration near the surface of the coating. The favorable corrosion resistance of the coating was proved by polarization curves and hydrogen collection test. The Mg-Al LDH significantly promoted cell adhesion, migration and proliferation in vitro. In addition, the coating almost fulfilled the request of the clinical application in the hemolysis ratio test. Finally, in vivo results indicated that the coating offered the greatest long-lasting protection from corrosion and triggered the mildest inflammation comparing to the pure Mg(OH)2 coatings and untreated magnesium alloy. Mg(OH)2 coating containing Mg-Al LDH in the present study shows a promising application in improving anticorrosion and biocompatibility of Mg alloys, and might act as a platform for a further modification of Mg alloys ascribed to its special layer structure.

[1]  N. Saito,et al.  Effect of treatment time in the Mg(OH)2/Mg–Al LDH composite film formed on Mg alloy AZ31 by steam coating on the corrosion resistance , 2016 .

[2]  Hyunju Jeong,et al.  Synthesis and characterization of thin films on magnesium alloy using a hydrothermal method , 2015 .

[3]  E. Han,et al.  Corrosion behavior of a self-sealing pore micro-arc oxidation film on AM60 magnesium alloy , 2015 .

[4]  M. Maitz,et al.  Application Of Phenol/Amine Copolymerized Film Modified Magnesium Alloys: Anticorrosion And Surface Biofunctionalization. , 2015, ACS applied materials & interfaces.

[5]  T. Cheng,et al.  Enhanced antibacterial properties, biocompatibility, and corrosion resistance of degradable Mg-Nd-Zn-Zr alloy. , 2015, Biomaterials.

[6]  Xuejun Cui,et al.  Self-sealing micro-arc oxidation coating on AZ91D Mg alloy and its formation mechanism , 2015 .

[7]  Xiaoping Shen,et al.  Solvothermal synthesis of NiCo-layered double hydroxide nanosheets decorated on RGO sheets for high performance supercapacitor , 2015 .

[8]  Donghui Wang,et al.  Selective Tumor Cell Inhibition Effect of Ni-Ti Layered Double Hydroxides Thin Films Driven by the Reversed pH Gradients of Tumor Cells. , 2015, ACS applied materials & interfaces.

[9]  Peng Tian,et al.  In vitro degradation behavior and cytocompatibility of biodegradable AZ31 alloy with PEO/HT composite coating. , 2015, Colloids and surfaces. B, Biointerfaces.

[10]  Hao Hu,et al.  Preparation and regulating cell adhesion of anion-exchangeable layered double hydroxide micropatterned arrays. , 2015, ACS applied materials & interfaces.

[11]  J. Atherton,et al.  Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications. , 2015, Chemical communications.

[12]  Peng Tian,et al.  In vitro degradation, hemolysis, and cytocompatibility of PEO/PLLA composite coating on biodegradable AZ31 alloy. , 2015, Journal of biomedical materials research. Part B, Applied biomaterials.

[13]  Motoki Inoue,et al.  In vitro and in vivo biocompatibility and corrosion behaviour of a bioabsorbable magnesium alloy coated with octacalcium phosphate and hydroxyapatite. , 2015, Acta biomaterialia.

[14]  Donghui Zhu,et al.  Endothelial responses of magnesium and other alloying elements in magnesium-based stent materials. , 2015, Metallomics : integrated biometal science.

[15]  J. Drelich,et al.  Rates of in vivo (arterial) and in vitro biocorrosion for pure magnesium. , 2015, Journal of biomedical materials research. Part A.

[16]  A. Afshar,et al.  Microstructure, mechanical properties, corrosion behavior and cytotoxicity of Mg–Zn–Al–Ca alloys as biodegradable materials , 2014 .

[17]  Yubo Fan,et al.  Magnesium based degradable biomaterials: A review , 2014, Frontiers of Materials Science.

[18]  Peng Tian,et al.  Hemocompatibility and selective cell fate of polydopamine-assisted heparinized PEO/PLLA composite coating on biodegradable AZ31 alloy. , 2014, Colloids and surfaces. B, Biointerfaces.

[19]  Nevija A. Watson,et al.  In Vitro Biocompatibility and Endothelialization of Novel Magnesium-Rare Earth Alloys for Improved Stent Applications , 2014, PloS one.

[20]  Zhi Ping Xu,et al.  Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. , 2014, Biomaterials.

[21]  M. Meyerhoff,et al.  A Nitric Oxide-Releasing Heparin Conjugate for Delivery of a Combined Antiplatelet/Anticoagulant Agent , 2014, Molecular pharmaceutics.

[22]  N. Frini-Srasra,et al.  Synthesis, structure and photocatalytic activity of calcined Mg-Al-Ti-layered double hydroxides , 2014, Korean Journal of Chemical Engineering.

[23]  Yuting Wang,et al.  In-situ hydrothermal crystallization Mg(OH)2 films on magnesium alloy AZ91 and their corrosion resistance properties , 2013 .

[24]  Q. Peng,et al.  Influence of biocorrosion on microstructure and mechanical properties of deformed Mg-Y-Er-Zn biomaterial containing 18R-LPSO phase. , 2013, Journal of the mechanical behavior of biomedical materials.

[25]  Yufeng Zheng,et al.  A review on in vitro corrosion performance test of biodegradable metallic materials , 2013 .

[26]  N. Barakat,et al.  Hydroxyapatite-doped poly(lactic acid) porous film coating for enhanced bioactivity and corrosion behavior of AZ31 Mg alloy for orthopedic applications , 2013 .

[27]  Ling Qin,et al.  Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[28]  Lin Mao,et al.  Comparison of biodegradable behaviors of AZ31 and Mg–Nd–Zn–Zr alloys in Hank's physiological solution , 2012 .

[29]  W. Ding,et al.  Effects of extrusion and heat treatment on the mechanical properties and biocorrosion behaviors of a Mg-Nd-Zn-Zr alloy. , 2012, Journal of the mechanical behavior of biomedical materials.

[30]  Qing-Guo Zhao,et al.  Hydrothermal synthesis of protective coating on magnesium alloy using de-ionized water , 2012 .

[31]  G. Ameer,et al.  Polymer‐Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications , 2012, Advanced functional materials.

[32]  D. Zhao,et al.  Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO₂) and its application in drug delivery. , 2011, Nanoscale.

[33]  Tae Woo Kim,et al.  Mesoporous layer-by-layer ordered nanohybrids of layered double hydroxide and layered metal oxide: highly active visible light photocatalysts with improved chemical stability. , 2011, Journal of the American Chemical Society.

[34]  Qing-Guo Zhao,et al.  Growth and characterization of Mg(OH) 2 film on magnesium alloy AZ31 , 2011 .

[35]  N. Scharnagl,et al.  Corrosion protection of magnesium alloy AZ31 sheets by spin coating process with poly(ether imide) [PEI] , 2010 .

[36]  A. Singh,et al.  Ti based biomaterials, the ultimate choice for orthopaedic implants – A review , 2009 .

[37]  Mark T. Gladwin,et al.  The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics , 2008, Nature Reviews Drug Discovery.

[38]  P. Chu,et al.  Corrosion behavior of AZ91 magnesium alloy treated by plasma immersion ion implantation and deposition in artificial physiological fluids , 2007 .

[39]  J. Uan,et al.  Characterization of Mg,Al-hydrotalcite conversion film on Mg alloy and Cl− and CO32- anion-exchangeability of the film in a corrosive environment , 2007 .

[40]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[41]  C. Dong,et al.  Surface modification of steels and magnesium alloy by high current pulsed electron beam , 2005 .

[42]  Horst Kessler,et al.  RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. , 2003, Biomaterials.

[43]  B O Palsson,et al.  Growth, Metabolic, and Antibody Production Kinetics of Hybridoma Cell Culture: 2. Effects of Serum Concentration, Dissolved Oxygen Concentration, and Medium pH in a Batch Reactor , 1991, Biotechnology progress.