Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
暂无分享,去创建一个
T. Appleby | W. Delaney | Ruby Z Cai | Xiaowu Chen | M. Clarke | Edward M. Doerffler | C. Kim | J. Link | A. Cho | Jie Xu | H. Pyun | Qiaoyin Wu | Mingzhe Ji | X. Sheng | T. Butler | R. Pakdaman | J. Cottell
[1] Geoffrey Dusheiko,et al. Telaprevir for previously untreated chronic hepatitis C virus infection. , 2011, The New England journal of medicine.
[2] A. Kwong,et al. Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors. , 2008, Current opinion in pharmacology.
[3] F. G. Njoroge,et al. Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection. , 2008, Accounts of chemical research.
[4] J. Sheldon,et al. Novel protease and polymerase inhibitors for the treatment of hepatitis C virus infection , 2007, Expert opinion on investigational drugs.
[5] S. Zeuzem,et al. Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study. , 2006, Gastroenterology.
[6] N. Butkiewicz,et al. SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells , 2006, Antimicrobial Agents and Chemotherapy.
[7] R. Francesco,et al. Challenges and successes in developing new therapies for hepatitis C , 2005, Nature.
[8] Steven R. LaPlante and Montse Llinàs-Brunet. Dynamics and Structure-based Design of Drugs Targeting the Critical Serine Protease of the Hepatitis C Virus - From a Peptidic Substrate to BILN 2061 , 2005 .
[9] C. Brochu,et al. Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based beta-strand mimics. , 2004, The Journal of organic chemistry.
[10] Steven R. LaPlante,et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus , 2003, Nature.
[11] P. Bonneau,et al. Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection. , 2003, Angewandte Chemie.
[12] M. Houghton,et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. , 1989, Science.