Stable SNPs in Malaria Antigen Genes in Isolated Populations

Surface antigens of the human malaria parasite Plasmodium falciparum are under intense immune pressure, and their loci are subject to positive selection ([ 1 ][1], [ 2 ][2]). P. falciparum shows substantial genetic variability, as seen in rapid emergence of drug resistance [e.g., 10 mutations in