Involvement of the corticotropin‐releasing hormone system in the pathogenesis of acne vulgaris

Background  The sebaceous gland exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides. Previous reports have confirmed the presence of a complete corticotropin‐releasing hormone (CRH) system in human sebocytes in vitro. The capability of hypothalamic CRH to induce lipid synthesis, induce steroidogenesis and interact with testosterone and growth hormone implicates a possibility of its involvement in the clinical development of acne.

[1]  D. Tobin,et al.  Corticotropin releasing hormone and the skin. , 2006, Frontiers in bioscience : a journal and virtual library.

[2]  A. Slominski,et al.  CRH functions as a growth factor/cytokine in the skin , 2006, Journal of cellular physiology.

[3]  R. Paus,et al.  Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  A. Slominski,et al.  CRH stimulates POMC activity and corticosterone production in dermal fibroblasts , 2005, Journal of Neuroimmunology.

[5]  A. Slominski,et al.  CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. , 2005, American journal of physiology. Endocrinology and metabolism.

[6]  A. Slominski,et al.  Corticotropin‐releasing hormone induces keratinocyte differentiation in the adult human epidermis , 2005, Journal of cellular physiology.

[7]  L. Goldsmith,et al.  What is the pathogenesis of acne? , 2005, Experimental dermatology.

[8]  C. Zouboulis,et al.  Neuroendocrine regulation of sebocytes – a pathogenetic link between stress and acne , 2004, Experimental dermatology.

[9]  C. Zouboulis.  Acne and sebaceous gland function. , 2004, Clinics in dermatology.

[10]  J. Mazurkiewicz,et al.  Differential expression of a cutaneous corticotropin-releasing hormone system. , 2004, Endocrinology.

[11]  G. Chrousos,et al.  Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists , 2002, Trends in Endocrinology & Metabolism.

[12]  A. Seasholtz,et al.  Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals. , 2002, The Journal of endocrinology.

[13]  T. Makino,et al.  Sebaceous glands in acne patients express high levels of neutral endopeptidase , 2002, Experimental dermatology.

[14]  W. Scherbaum,et al.  Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[15]  C. Zouboulis.  Human Skin: An Independent Peripheral Endocrine Organ , 2001, Hormone Research in Paediatrics.

[16]  C. Zouboulis,et al.  Sebocytes are the key regulators of androgen homeostasis in human skin. , 2001, The Journal of investigative dermatology.

[17]  R. Paus,et al.  Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. , 2000, Physiological reviews.

[18]  A. Slominski,et al.  The skin produces urocortin. , 2000, The Journal of clinical endocrinology and metabolism.

[19]  C. Zouboulis,et al.  Establishment and Characterization of an Immortalized Human Sebaceous Gland Cell Line (SZ95)1 , 1999 .

[20]  T. Lotti,et al.  Neuropeptides and skin disorders. The new frontiers of neuro–endocrine–cutaneous immunology , 1999, International journal of dermatology.

[21]  D. Torpy,et al.  Corticotropin‐Releasing Hormone and Inflammation , 1998, Annals of the New York Academy of Sciences.

[22]  T. Luger,et al.  The Pilosebaceous Unit Is Part of the Skin Immune System , 1998, Dermatology.

[23]  R. Paus,et al.  Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[24]  M. Mihm,et al.  POTENTIAL MECHANISM OF SKIN RESPONSE TO STRESS , 1996, International journal of dermatology.

[25]  C. Elmets,et al.  Messenger RNAs for the multifunctional cytokines interleukin‐1α, interleukin‐1β and tumor necrosis factor‐α are present in adnexal tissues and in dermis of normal human skin , 1995, Experimental dermatology.

[26]  W J Cunliffe,et al.  Acne vulgaris: an investigation into the number of anaerobic diphtheroids and members of Micrococcaceae the in normal and acne skin , 1977, The British journal of dermatology.

[27]  C. Zouboulis,et al.  Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands , 2005, Journal of Molecular Medicine.

[28]  R. Paus,et al.  The human hair bulb is a source and target of CRH. , 2004, The Journal of investigative dermatology.

[29]  C. Zouboulis.  The human skin as a hormone target and an endocrine gland. , 2004, Hormones.

[30]  R. Rosenfield,et al.  Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. , 1999, Endocrinology.

[31]  C. Zouboulis,et al.  Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). , 1999, The Journal of investigative dermatology.

[32]  H. Gollnick,et al.  Culture of human sebocytes and markers of sebocytic differentiation in vitro. , 1991, Skin pharmacology : the official journal of the Skin Pharmacology Society.

[33]  J. Roberts,et al.  Hormonal regulation of POMC gene expression. , 1989, Annual review of physiology.

[34]  J. Mazurkiewicz,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society COMMENTS Characterization of Corticotropin-Releasing Hormone , 2022 .

[35]  S. Kawana,et al.  The FASEB Journal express article 10.1096/fj.01-0254-fje. Published online August 17, 2001. In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin , 2022 .

[36]  G. Chrousos,et al.  Printed in U.S.A. Copyright © 1998 by The Endocrine Society Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects* , 2022 .