The household economic burden of non-communicable diseases in 18 countries

Background Non-communicable diseases (NCDs) are the leading cause of death globally. In 2014, the United Nations committed to reducing premature mortality from NCDs, including by reducing the burden of healthcare costs. Since 2014, the Prospective Urban and Rural Epidemiology (PURE) Study has been collecting health expenditure data from households with NCDs in 18 countries. Methods Using data from the PURE Study, we estimated risk of catastrophic health spending and impoverishment among households with at least one person with NCDs (cardiovascular disease, diabetes, kidney disease, cancer and respiratory diseases; n=17 435), with hypertension only (a leading risk factor for NCDs; n=11 831) or with neither (n=22 654) by country income group: high-income countries (Canada and Sweden), upper middle income countries (UMICs: Brazil, Chile, Malaysia, Poland, South Africa and Turkey), lower middle income countries (LMICs: the Philippines, Colombia, India, Iran and the Occupied Palestinian Territory) and low-income countries (LICs: Bangladesh, Pakistan, Zimbabwe and Tanzania) and China. Results The prevalence of catastrophic spending and impoverishment is highest among households with NCDs in LMICs and China. After adjusting for covariates that might drive health expenditure, the absolute risk of catastrophic spending is higher in households with NCDs compared with no NCDs in LMICs (risk difference=1.71%; 95% CI 0.75 to 2.67), UMICs (0.82%; 95% CI 0.37 to 1.27) and China (7.52%; 95% CI 5.88 to 9.16). A similar pattern is observed in UMICs and China for impoverishment. A high proportion of those with NCDs in LICs, especially women (38.7% compared with 12.6% in men), reported not taking medication due to costs. Conclusions Our findings show that financial protection from healthcare costs for people with NCDs is inadequate, particularly in LMICs and China. While the burden of NCD care may appear greatest in LMICs and China, the burden in LICs may be masked by care foregone due to costs. The high proportion of women reporting foregone care due to cost may in part explain gender inequality in treatment of NCDs.

[1]  Saheed Olawale Olayiwola,et al.  Household economic costs associated with mental, neurological and substance use disorders: a cross-sectional survey in six low- and middle-income countries , 2019, BJPsych open.

[2]  S. Subramanian,et al.  Socioeconomic Gradients and Distribution of Diabetes, Hypertension, and Obesity in India , 2019, JAMA network open.

[3]  N. Roberts,et al.  A systematic review of associations between non-communicable diseases and socioeconomic status within low- and lower-middle-income countries , 2018, Journal of global health.

[4]  S. Yusuf,et al.  Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: evidence from the PURE observational study , 2018, The Lancet. Global health.

[5]  A. Wagstaff,et al.  Progress on catastrophic health spending in 133 countries: a retrospective observational study. , 2017, The Lancet. Global health.

[6]  S. Yusuf,et al.  Secondary CV Prevention in South America in a Community Setting: The PURE Study. , 2017, Global heart.

[7]  S. Yusuf,et al.  Availability and affordability of blood pressure-lowering medicines and the effect on blood pressure control in high-income, middle-income, and low-income countries: an analysis of the PURE study data. , 2017, The Lancet. Public health.

[8]  Nia Roberts,et al.  Socioeconomic status and non-communicable disease behavioural risk factors in low-income and lower-middle-income countries: a systematic review , 2017, The Lancet. Global health.

[9]  Qun Wang,et al.  The economic burden of chronic non-communicable diseases in rural Malawi: an observational study , 2016, BMC Health Services Research.

[10]  J. Cylus,et al.  Monitoring financial protection to assess progress towards universal health coverage in Europe , 2016 .

[11]  V. Fuster,et al.  Acute coronary syndromes in low- and middle-income countries: Moving forward. , 2016, International journal of cardiology.

[12]  M. Mckee,et al.  Persistent low adherence to hypertension treatment in Kyrgyzstan: How can we understand the role of drug affordability? , 2016, Health policy and planning.

[13]  C. Grady,et al.  Women’s autonomy in health care decision-making in developing countries: a synthesis of the literature , 2016, International journal of women's health.

[14]  D. Levine,et al.  Insuring health or insuring wealth? An experimental evaluation of health insurance in rural Cambodia , 2016 .

[15]  S. Yusuf,et al.  Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data , 2016, The Lancet.

[16]  O. Franco,et al.  The global impact of non-communicable diseases on households and impoverishment: a systematic review , 2015, European Journal of Epidemiology.

[17]  Tej K. Khalsa,et al.  Standards for the Uniform Reporting of Hypertension in Adults Using Population Survey Data: Recommendations From the World Hypertension League Expert Committee , 2014, Journal of clinical hypertension.

[18]  Martin McKee,et al.  Cardiovascular risk and events in 17 low-, middle-, and high-income countries. , 2014, The New England journal of medicine.

[19]  S. Yusuf,et al.  Association of urinary sodium and potassium excretion with blood pressure. , 2014, The New England journal of medicine.

[20]  A. Wagstaff,et al.  CATA Meets IMPOV: A Unified Approach to Measuring Financial Protection in Health , 2014 .

[21]  S. Yusuf,et al.  Prospective Urban Rural Epidemiology (PURE) study: Baseline characteristics of the household sample and comparative analyses with national data in 17 countries. , 2013, American heart journal.

[22]  Martin McKee,et al.  Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. , 2013, JAMA.

[23]  D. Evans,et al.  The financial burden from non-communicable diseases in low- and middle-income countries: a literature review , 2013, Health Research Policy and Systems.

[24]  A. Moran,et al.  The economic burden of chronic disease care faced by households in Ukraine: a cross-sectional matching study of angina patients , 2013, International Journal for Equity in Health.

[25]  O. O’Donnell,et al.  Catastrophic medical expenditure risk , 2012, The Lancet.

[26]  Jeremy D. Goldhaber-Fiebert,et al.  Diabetes, Its Treatment, and Catastrophic Medical Spending in 35 Developing Countries , 2012, Diabetes Care.

[27]  H. Rao Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey , 2012 .

[28]  S. Yusuf,et al.  Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey , 2011, The Lancet.

[29]  Peter C Smith,et al.  Towards Improved Measurement of Financial Protection in Health , 2011, PLoS medicine.

[30]  Mark D. Huffman,et al.  A Cross-Sectional Study of the Microeconomic Impact of Cardiovascular Disease Hospitalization in Four Low- and Middle-Income Countries , 2011, PloS one.

[31]  Salim Yusuf,et al.  The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries. , 2009, American heart journal.

[32]  S. Galea,et al.  Borrowing and selling to pay for health care in low- and middle-income countries. , 2009, Health affairs.

[33]  E. van Doorslaer,et al.  Coping with Health-Care Costs: Implications for the Measurement of Catastrophic Expenditures and Poverty , 2008, Health economics.

[34]  K. Fukino,et al.  The availability and affordability of selected essential medicines for chronic diseases in six low- and middle-income countries. , 2007, Bulletin of the World Health Organization.

[35]  S. West,et al.  Contribution of Sex-linked Biology and Gender Roles to Disparities with Trachoma , 2004, Emerging infectious diseases.

[36]  C. Murray,et al.  Household catastrophic health expenditure: a multicountry analysis , 2003, The Lancet.

[37]  S. Lewallen,et al.  Gender and use of cataract surgical services in developing countries. , 2002, Bulletin of the World Health Organization.

[38]  Duncan C. Thomas,et al.  Bargaining power within couples and use of prenatal and delivery care in Indonesia. , 2001, Studies in family planning.

[39]  F. Castro-Leal,et al.  Public spending on health care in Africa: do the poor benefit? , 2000, Bulletin of the World Health Organization.

[40]  Michael A. Clemens,et al.  Genuine Savings Rates in Developing Countries , 1999 .