Correlation between cerebral biomarkers and optic nerve sheath diameter in patients with severe preeclampsia

ABSTRACT Objective: To examine the correlation between plasma cerebral biomarkers (S100B and neuron-specific enolase (NSE)) and ultrasonographic optic-nerve-sheath-diameter (ONSD) in preeclampsia. Methods: Thirty preeclampsia patients and 27 controls were included. Mann-Whitney-U test was used for comparison of S100B, NSE, and ONSD in preeclampsia vs. controls. Kendall’s tau was used to assess the correlation between biomarkers and ONSD (p < 0.05 significant). Results: ONSD, S100B and NSE were significantly higher in preeclampsia (p < 0.001, p = 0.004, and p < 0.001, respectively). There was significant correlation between NSE levels and ONSD: Kendall’s tau = 0.26; p = 0.01. Conclusions: S100B and NSE are elevated in severe preeclampsia. NSE correlates with increased ONSD suggesting cerebral edema.

[1]  J. Ambrožič,et al.  Ocular ultrasonography for diagnosing increased intracranial pressure in patients with severe preeclampsia. , 2018, International journal of obstetric anesthesia.

[2]  T. Naessén,et al.  Cerebral Biomarkers in Women With Preeclampsia Are Still Elevated 1 Year Postpartum. , 2016, American journal of hypertension.

[3]  L. Bergman,et al.  Plasma Levels of the Cerebral Biomarker, Neuron-Specific Enolase, are Elevated During Pregnancy in Women Developing Preeclampsia , 2016, Reproductive Sciences.

[4]  B. Sibai,et al.  The Role of Headache in the Classification and Management of Hypertensive Disorders in Pregnancy. , 2015, Obstetrics and gynecology.

[5]  Y. Berhan,et al.  Maternal Mortality Predictors in Women with Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study , 2015, Ethiopian journal of health sciences.

[6]  B. Artunc-Ulkumen,et al.  Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia , 2015, Archives of Gynecology and Obstetrics.

[7]  C. Robertson,et al.  Monitoring Biomarkers of Cellular Injury and Death in Acute Brain Injury , 2014, Neurocritical Care.

[8]  T. Naessén,et al.  Plasma Levels of S100B in Preeclampsia and Association With Possible Central Nervous System Effects , 2014, American journal of hypertension.

[9]  A. González-Quevedo,et al.  Short-term prognostic value of serum neuron specific enolase and S100B in acute stroke patients. , 2012, Clinical biochemistry.

[10]  A. Wikström,et al.  Plasma levels of S100B during pregnancy in women developing pre-eclampsia. , 2012, Pregnancy hypertension.

[11]  D. Benhamou,et al.  Optic Nerve Sheath Diameter Used as Ultrasonographic Assessment of the Incidence of Raised Intracranial Pressure in Preeclampsia: A Pilot Study , 2012, Anesthesiology.

[12]  D. Souza,et al.  Serum S100B in pregnancy complicated by preeclampsia: A case-control study. , 2012, Pregnancy hypertension.

[13]  Z. Stelmasiak,et al.  Some markers of neuronal damage in cerebrospinal fluid of multiple sclerosis patients in relapse. , 2011, Folia neuropathologica.

[14]  K. Joseph,et al.  Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. , 2011, Best practice & research. Clinical obstetrics & gynaecology.

[15]  K. Khan,et al.  How accurate are maternal symptoms in predicting impending complications in women with preeclampsia? A systematic review and meta‐analysis , 2011, Acta obstetricia et gynecologica Scandinavica.

[16]  J. Bäuerle,et al.  Sonographic assessment of the optic nerve sheath in idiopathic intracranial hypertension , 2011, Journal of Neurology.

[17]  T. Beems,et al.  GFAP and S100B are biomarkers of traumatic brain injury , 2010, Neurology.

[18]  D. Twickler,et al.  Cerebral infarction in eclampsia. , 2004, American journal of obstetrics and gynecology.

[19]  O. Amaral,et al.  Serum S100B in pregnancy-related hypertensive disorders: a case-control study. , 2004, Clinical chemistry.

[20]  Paulo Borba,et al.  Diffusion imaging may predict reversible brain lesions in eclampsia and severe preeclampsia: initial experience. , 2003, American journal of obstetrics and gynecology.

[21]  B. Romner,et al.  Biochemical serum markers for brain damage: a short review with emphasis on clinical utility in mild head injury. , 2003, Restorative neurology and neuroscience.

[22]  R. Wityk,et al.  Don't throw in the towel! A case of reversible coma , 2002, Journal of neurology, neurosurgery, and psychiatry.

[23]  J. Moodley,et al.  Neurological complications associated with the pre‐eclampsia/eclampsia syndrome , 2000, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[24]  J. Polak,et al.  Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. , 2000, Radiology.