Verification of patient position and delivery of IMRT by electronic portal imaging.

BACKGROUND AND PURPOSE The purpose of the work presented in this paper was to determine whether patient positioning and delivery errors could be detected using electronic portal images of intensity modulated radiotherapy (IMRT). PATIENTS AND METHODS We carried out a series of controlled experiments delivering an IMRT beam to a humanoid phantom using both the dynamic and multiple static field method of delivery. The beams were imaged, the images calibrated to remove the IMRT fluence variation and then compared with calibrated images of the reference beams without any delivery or position errors. The first set of experiments involved translating the position of the phantom both laterally and in a superior/inferior direction a distance of 1, 2, 5 and 10 mm. The phantom was also rotated 1 and 2 degrees . For the second set of measurements the phantom position was kept fixed and delivery errors were introduced to the beam. The delivery errors took the form of leaf position and segment intensity errors. RESULTS The method was able to detect shifts in the phantom position of 1 mm, leaf position errors of 2 mm, and dosimetry errors of 10% on a single segment of a 15 segment IMRT step and shoot delivery (significantly less than 1% of the total dose). CONCLUSIONS The results of this work have shown that the method of imaging the IMRT beam and calibrating the images to remove the intensity modulations could be a useful tool in verifying both the patient position and the delivery of the beam.

[1]  James F Dempsey,et al.  Verification of step-and-shoot IMRT delivery using a fast video-based electronic portal imaging device. , 2004, Medical physics.

[2]  H. Suit,et al.  The Gray Lecture 2001: coming technical advances in radiation oncology. , 2002, International journal of radiation oncology, biology, physics.

[3]  D. Dearnaley,et al.  IMRT clinical implementation: Prostate and pelvic node irradiation using Helios and a 120‐leaf multileaf collimator , 2002, Journal of applied clinical medical physics.

[4]  Kenneth G A Gilhuijs,et al.  Application of video imaging for improvement of patient set-up. , 2003, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[5]  E B Podgorsak,et al.  Verification of segmented beam delivery using a commercial electronic portal imaging device. , 1999, Medical physics.

[6]  A G Glendinning,et al.  Dosimetric properties of the Theraview fluoroscopic electronic portal imaging device. , 2000, The British journal of radiology.

[7]  Maarten L P Dirkx,et al.  Fast and accurate leaf verification for dynamic multileaf collimation using an electronic portal imaging device. , 2002, Medical physics.

[8]  G W Sherouse,et al.  Computation of digitally reconstructed radiographs for use in radiotherapy treatment design. , 1990, International journal of radiation oncology, biology, physics.

[9]  L. Antonuk Electronic portal imaging devices: a review and historical perspective of contemporary technologies and research. , 2002, Physics in medicine and biology.

[10]  T Haycocks,et al.  Positioning errors and prostate motion during conformal prostate radiotherapy using on-line isocentre set-up verification and implanted prostate markers. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[11]  J. Fowler,et al.  Image guidance for precise conformal radiotherapy. , 2003, International journal of radiation oncology, biology, physics.

[12]  Steve Webb,et al.  Intensity-Modulated Radiation Therapy , 1996, International journal of radiation oncology, biology, physics.

[13]  J. Wong,et al.  Flat-panel cone-beam computed tomography for image-guided radiation therapy. , 2002, International journal of radiation oncology, biology, physics.

[14]  M van Herk,et al.  Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration. , 1995, International journal of radiation oncology, biology, physics.

[15]  J A Rowlands,et al.  Imaging of 1.0-mm-diameter radiopaque markers with megavoltage X-rays: an improved online imaging system. , 2002, International journal of radiation oncology, biology, physics.

[16]  D A Jaffray,et al.  Managing geometric uncertainty in conformal intensity-modulated radiation therapy. , 1999, Seminars in radiation oncology.

[17]  Gary A. Ezzell,et al.  The overshoot phenomenon in step‐and‐shoot IMRT delivery , 2001, Journal of applied clinical medical physics.

[18]  Rasika Rajapakshe,et al.  Pseudocorrelation: a fast, robust, absolute, grey-level image alignment algorithm. , 1994 .

[19]  P. C. Williams,et al.  Requirements for leaf position accuracy for dynamic multileaf collimation. , 2000, Physics in medicine and biology.

[20]  D A Low,et al.  Intensity‐modulated radiation therapy in head and neck cancers: The Mallinckrodt experience , 2000, International journal of cancer.

[21]  P. Levendag,et al.  Electronic portal image assisted reduction of systematic set-up errors in head and neck irradiation. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[22]  Michael J. Zelefsky,et al.  High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. , 2002, International journal of radiation oncology, biology, physics.

[23]  M van Herk,et al.  Leaf position verification during dynamic beam delivery: a comparison of three applications using electronic portal imaging. , 2000, Medical physics.

[24]  Henk Huizenga,et al.  Set-up improvement in head and neck radiotherapy using a 3D off-line EPID-based correction protocol and a customised head and neck support. , 2003, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[25]  D P Dearnaley,et al.  Intensity modulated radiation therapy: a clinical review. , 2000, The British journal of radiology.

[26]  P. Munro,et al.  A review of electronic portal imaging devices (EPIDs). , 1992, Medical physics.

[27]  Catharine H Clark,et al.  The use of electronic portal imaging to verify patient position during intensity-modulated radiotherapy delivered by the dynamic MLC technique. , 2002, International journal of radiation oncology, biology, physics.

[28]  T. Knöös,et al.  The dosimetric verification of a pencil beam based treatment planning system. , 1994, Physics in medicine and biology.

[29]  A Fenster,et al.  A digital fluoroscopic imaging device for radiotherapy localization. , 1990, International journal of radiation oncology, biology, physics.

[30]  C C Ling,et al.  Relative profile and dose verification of intensity-modulated radiation therapy. , 2000, International journal of radiation oncology, biology, physics.

[31]  R Mohan,et al.  The effect of setup uncertainty on normal tissue sparing with IMRT for head-and-neck cancer. , 2001, International journal of radiation oncology, biology, physics.

[32]  D Huyskens,et al.  Pre-treatment dosimetric verification by means of a liquid-filled electronic portal imaging device during dynamic delivery of intensity modulated treatment fields. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[33]  D. G. Lewis,et al.  A linear array, scintillation crystal-photodiode detector for megavoltage imaging. , 1991, Medical physics.

[34]  M C Kirby,et al.  The use of an electronic portal imaging device for exit dosimetry and quality control measurements. , 1995, International journal of radiation oncology, biology, physics.

[35]  Marcel van Herk,et al.  Portal imaging to assess set-up errors, tumor motion and tumor shrinkage during conformal radiotherapy of non-small cell lung cancer. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[36]  M Partridge,et al.  Independent verification using portal imaging of intensity-modulated beam delivery by the dynamic MLC technique. , 1998, Medical physics.