论文信息 - Pharmacokinetic evidence for the induction of lopinavir metabolism by efavirenz.

Pharmacokinetic evidence for the induction of lopinavir metabolism by efavirenz.

AIMS The influence of efavirenz on lopinavir pharmacokinetics was investigated using a population approach. METHODS Forty-five HIV patients treated with lopinavir/ritonavir plus efavirenz (A) and 24 patients treated with lopinavir/ritonavir plus nucleoside/nucleotide reverse transcriptase inhibitors (B) were studied. RESULTS A relationship (P < 0.01) was established between the elimination rate constant of lopinavir (k(10)) and treatment with efavirenz. Mean k(10) was higher in group A than in group B (0.3838 vs 0.2810 h(-1)) (P < 0.001, 95% confidence interval for difference between means 0.1004, 0.1052). CONCLUSIONS These results suggest that lopinavir metabolism is induced by efavirenz.

P. Jolliet | F. Raffi | C. Allavena | E. Dailly

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