Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase--an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line.

[1]  Dong Hee Lee,et al.  Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. , 2006, Biological & pharmaceutical bulletin.

[2]  J. Cidlowski,et al.  Selective Role of Intracellular Chloride in the Regulation of the Intrinsic but Not Extrinsic Pathway of Apoptosis in Jurkat T-cells* , 2006, Journal of Biological Chemistry.

[3]  M. Paul,et al.  Merits of HPLC-based method over spectrophotometric method for assessing the kinetics and inhibition of mammalian adenosine deaminase. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[4]  M. Paul,et al.  6-Mercaptopurine and Daunorubicin Double Drug Liposomes—Preparation, Drug-Drug Interaction and Characterization , 2005, Journal of liposome research.

[5]  L. Lennard.  The clinical pharmacology of 6-mercaptopurine , 2005, European Journal of Clinical Pharmacology.

[6]  A. Romanha,et al.  An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells. , 2004, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[7]  V. Micheli,et al.  Simple non-radiochemical HPLC-linked method for screening for purine metabolism disorders using dried blood spot. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[8]  H. Balaram,et al.  A point mutation at the subunit interface of hypoxanthine–guanine–xanthine phosphoribosyltransferase impairs activity: role of oligomerization in catalysis , 2002, FEBS letters.

[9]  M. Relling,et al.  HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy. , 2002, Clinical chemistry.

[10]  H. Balaram,et al.  Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes. , 2000, Biochemical and biophysical research communications.

[11]  J. Lilleyman,et al.  In vitro metabolism of 6-mercaptopurine by human liver cytosol. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.

[12]  J. Stobaugh,et al.  Determination of intracellular levels of 6-mercaptopurine metabolites in erythrocytes utilizing capillary electrophoresis with laser-induced fluorescence detection. , 1995, Analytical biochemistry.

[13]  D. Pinkel.  Intravenous mercaptopurine: life begins at 40. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  A. Lenoir,et al.  High-performance liquid chromatographic determination of thiopurine metabolites of azathioprine in biological fluids. , 1993, Journal of chromatography.

[15]  L. Lennard,et al.  High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample. , 1992, Journal of chromatography.

[16]  B. Carleton,et al.  Reversed-phase high-performance liquid chromatographic approach to determine total lymphocyte concentrations of 6-thioguanine, methylmercaptopurine and methylthioguanine in humans. , 1991, Journal of Chromatography A.

[17]  A. Belce,et al.  Xanthine oxidase levels in human brain tumors. , 1990, Cancer letters.

[18]  G. Erdmann,et al.  A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy. , 1990, Biomedical chromatography : BMC.

[19]  K. Patel,et al.  Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues. , 1989, British Journal of Cancer.

[20]  K. Schmiegelow,et al.  Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography. , 1989, Scandinavian journal of clinical and laboratory investigation.

[21]  P. V. van Dreal,et al.  HPLC Analysis of 6-Mercaptopurine and Metabolites in Extracellular Body Fluids , 1988, Annals of clinical biochemistry.

[22]  J. Strong,et al.  A clinically useful ion-pairing high-performance liquid chromatographic assay for the monophosphate metabolites of thioguanine and mercaptopurine in human neoplastic cells. , 1987, Analytical biochemistry.

[23]  P. Gillery,et al.  A continuous-flow technique with Coomassie Brilliant Blue for cerebrospinal fluid protein assay. , 1985, Clinical Chemistry.

[24]  A. V. Van Gennip,et al.  Nucleotide profiles of normal human blood cells determined by high-performance liquid chromatography. , 1985, Analytical biochemistry.

[25]  J. Holcenberg,et al.  A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. , 1985, Analytical biochemistry.

[26]  R. Riccardi,et al.  Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? , 1983, The New England journal of medicine.

[27]  S. Dedhar,et al.  Specific and sensitive combined high-performance liquid chromatographic-flow fluorometric assay for intracellular 6-thioguanine nucleotides metabolites of 6-mercaptopurine and 6-thioguanine. , 1978, Journal of chromatography.

[28]  A. Bieber,et al.  High-pressure liquid chromatography: a tool for study of enzyme reactions involving purines and purine nucleotides. , 1977, Analytical Biochemistry.

[29]  G. Lyon,et al.  Identification of 6-methylmercaptopurine ribonucleoside 5'-diphosphate and 5'-triphosphate as metabolites of 6-mercaptopurine in man. , 1974, Cancer research.

[30]  J. A. Bain,et al.  Metabolic and therapeutic effects of allopurinol in patients with leukemia and gout , 1966 .

[31]  W. J. Spillman.  INHERITANCE OF COLOR COAT IN SWINE. , 1906, Science.